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IRAK2 L392V showed intact binding to, but impaired ubiquitination of, tumor necrosis factor (show TNF Proteins) receptor-associated factor 6, a vital step in signal transduction
This for the first time implicates human IRAK2 in a human disease and highlights the R214G IRAK2 variant as a potential novel and broadly applicable biomarker for disease or as a therapeutic intervention point.
Human miR (show MLXIP Proteins)-373 is silenced by histone modification in lung cancer cells and is a negative regulator of the mesenchymal phenotype through downstream IRAK2 and LAMP1 (show LAMP1 Proteins) target genes.
Results suggest that D431E-IRAK2 (interleukin-1 receptor-associated kinase-2) increases NF-kappaB (show NFKB1 Proteins) activation by promoting TRAF6 (show TRAF6 Proteins) ubiquitination by enhancing TNF Receptor-Associated Factor 6 (TRAF6 (show TRAF6 Proteins))-IRAK2 interaction.
These findings demonstrate an unexpected linkage of the innate immunity machinery to unfolded protein response signaling, revealing IRAK2 as a novel amplifier of the IRE1 (show ERN1 Proteins) pathway.
Human interleukin-1 receptor-associated kinase-2 is essential for Toll (show TLR4 Proteins)-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha (show TNF Proteins).
analysis of differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1 (show IRAK1 Proteins)) and IRAK-2 by microRNA-146a and NF-kappaB (show NFKB1 Proteins) in stressed human astroglial cells and in Alzheimer disease
Our data show that interleukin-1R-associated kinase 2 is a novel and critical component of TGFbeta (show TGFB1 Proteins) signaling.
the crystal structure of the MyD88 (show MYD88 Proteins)-IRAK4 (show IRAK4 Proteins)-IRAK2 death domain (DD) complex, which surprisingly reveals a left-handed helical oligomer that consists of 6 MyD88 (show MYD88 Proteins), 4 IRAK4 (show IRAK4 Proteins) and 4 IRAK2 DDs
CTCF (show CTCF Proteins) plays a major role in IRAK2 transcription; EMSA revealed a CTCF (show CTCF Proteins)-binding site within the mouse Irak2 promoter
Our results establish that the IRAK2-TRAF6 (show TRAF6 Proteins) interaction is rate limiting for the late, but not the early phase of cytokine production in bone marrow-derived macrophages and plasmacytoid dendritic cells
IRAK2 plays a key role in the TLR9 (show TLR9 Proteins)-mediated transcriptional regulation of Irak-m (show IRAK3 Proteins) expression by sustaining activation of PKD1 (show PKD1 Proteins) and NF-kappaB (show NFKB1 Proteins)
IRAK-2 mediates pathology in a CD4 T cell specific manner by promoting Th17 cell development through enhancement of IL-1beta-induced activation of transcription factors RORgammat and BATF.
the kinase activity of IRAK2 is required for the optimal activation of mitogen-activated protein kinase (show MAPK1 Proteins) signaling, which regulates cytokine and chemokine (show CCL1 Proteins) production at posttranscriptional levels.
IRAK2 is a negative regulator of Toll (show TLR4 Proteins)-like receptor (TLR)9 (show TLR9 Proteins)-induced interferon (show IFNA Proteins) production in plasmacytoid dendritic cells.
Alternative splicing of the Irak2 gene in mice will generate agonistic or antagonistic Irak2 isoforms, which is likely to have consequences for the regulation of Toll (show TLR4 Proteins)-like receptors signaling.
TRAF6 (show TRAF6 Proteins) and interleukin receptor-associated kinase 2 are novel binding partners for PS1 (show PSEN1 Proteins), and IL-1R1 is a new substrate for presenilin-dependent gamma-secretase cleavage
These results reveal that IRAK2 is required for LPS (show TLR4 Proteins)-mediated post-transcriptional control of cytokine and chemokine (show CCL1 Proteins) expression, which plays an essential role in TLR4 (show TLR4 Proteins)-induced septic shock.
Data demonstrate that IRAK-2 is an essential component of the early TLR response in MOLF/Ei mice and show a distinct pathway of p38 (show CRK Proteins) and NF-kappaB (show NFKB1 Proteins) activation in this model organism.
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.
interleukin-1 receptor associated kinase-2
, interleukin-1 receptor-associated kinase-like 2
, interleukin-1 receptor-associated kinase 2c