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Following spring viremia of carp (show ANKRD1 ELISA Kits) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (show ANKRD1 ELISA Kits) virus. data provide evidence that fish and mammals have evolved a similar IRF (show TRIM63 ELISA Kits)-dependent regulatory mechanism fine-tuning IFN gene activation.
Interferon (show IFNA ELISA Kits) regulatory factor (IRF (show TRIM63 ELISA Kits))10 inhibits the expression of IFN1 and IFN3 to avoid an excessive immune response, a unique regulation mechanism of the IFN responses in lower vertebrates.
Hepatitis A virus protein 2B suppresses beta interferon (show IFNA ELISA Kits) (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.
MyD88 (show MYD88 ELISA Kits) interacts with interferon (show IFNA ELISA Kits) regulatory factor (IRF) 3 and IRF7 (show IRF7 ELISA Kits) in Atlantic salmon (Salmo salar)
above findings suggest that ATG5-ATG12 positively regulate anti-viral NF-kappaB and IRF3 signaling during FMDV infection, thereby limiting FMDV proliferation. FMDV has evolved mechanisms to counteract the antiviral function of ATG5-ATG12, via degradation of them by viral protein 3C(pro).
NEMO (show IKBKG ELISA Kits)-IKKbeta (show IKBKB ELISA Kits) Are Essential for IRF3 and NF-kappaB (show NFKB1 ELISA Kits) Activation in the cGAS-STING Pathway
these data suggest that HNSs, an antagonist of host innate immunity, interacts with TBK1 (show TBK1 ELISA Kits) and thereby hinders the association of TBK1 (show TBK1 ELISA Kits) with its substrate IRF3, thus blocking IRF3 activation and transcriptional induction of the cellular antiviral responses.
IRF3 is a major transcriptional regulator of adipose inflammation and is involved in maintaining systemic glucose and energy homeostasis
this study shows that IRF-3-mediated apoptosis of virus-infected cells could be an effective antiviral mechanism, without expression of the interferon (show IFNA ELISA Kits)-stimulated genes
Data in this study show that cFLIPL inhibits IFN regulatory factor 3 (IRF3), a transcription factor central for IFN-beta (show IFNB1 ELISA Kits) and IFN-stimulated gene expression.
1,8-cineole potentiates the antiviral activity of IRF3 in addition to its inhibitory effect on proinflammatory NF-kappaB (show NFKB1 ELISA Kits) signaling in an ex vivo model of rhinosinusitis.
TBK1 (show TBK1 ELISA Kits) complexes required for the phosphorylation of IRF3 and the production of interferon-beta (show IFNB1 ELISA Kits) have been identified.
RIG-I (show DDX58 ELISA Kits)-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway
cGAs recognizes bacterial/viral DNA, and is a strong activator of STING that can further activate IRF3 and subsequent type I interferon (show IFNA ELISA Kits) production. (Review)
The authors used recombinant classical swine fever virus N(pro) and swine IRF3 proteins and show that N(pro) interacts with IRF3 directly without additional proteins and forms a soluble 1:1 complex.
Amino acid residues in the N-terminal domain of Npro are involved in the stability of Npro, in interaction of Npro with IRF-3 and subsequent degradation of IRF-3, leading to downregulation of IFN-alpha (show IFNA ELISA Kits)/beta production.
The obtained results showed that PRRSV nsp1 could inhibit Poly(I:C)-induced IFN-beta (show IFNB1 ELISA Kits) promoter activity in MARC (show CCL7 ELISA Kits)-145 cells by down-regulating the protein level of IRF-3 and inhibiting the phosphorylation of IRF-3.
proteasomal degradation of IRF3 is induced by a direct or indirect interaction with N(pro).
The IRF-3 pathway is essential for tick-borne encephalitis virus-induced RANTES (show CCL5 ELISA Kits) production in the brain.
Yersinia YopJ negatively regulates IRF3-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling.
Findings indicate that STING-TBK1 (show TBK1 ELISA Kits)-IRF3 pathway mediates a crosstalk between ER stress and apoptosis during M. bovis infection, which can effectively control intracellular bacteria.
GPR146 has an antiviral role in fighting against viral infection, although the GPR146-mediated protection is eliminated by IRF3/HES1-signalling.
Results establish Irf3, known mostly for its role in antiviral responses, as a transcription factor involved in the induction of Th2 responses through the promotion of pro-Th2 costimulation in CD11b (show ITGAM ELISA Kits)(+) dendritic cells
Rubicon specifically interacts with the interferon (show IFNA ELISA Kits) regulatory factor (IRF (show TRIM63 ELISA Kits)) association domain (IAD) of IRF3, and this interaction leads to inhibition of the dimerization of IRF3, which negatively regulates interferon (show IFNA ELISA Kits)-mediated antiviral response.
this study shows that IRF3 in antigen-presenting cells and T cells is required for optimal T-cell effector function and the ability of T cells to influence innate immune function of antigen-presenting cells
The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta (show IFNB1 ELISA Kits) promoter activity and induces IRF3 degradation.
cpBVDV infection causes a marked loss of interferon regulatory factor 3 (IRF-3), a cellular transcription factor that controls interferon (show IFNA ELISA Kits) synthesis.
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
interferon regulatory factor 3
, interferon regulatory factor 3-like