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Browse our IRF5 Proteins (IRF5)

Full name:
Interferon Regulatory Factor 5 Proteins (IRF5)
On www.antibodies-online.com are 16 Interferon Regulatory Factor 5 (IRF5) Proteins from 6 different suppliers available. Additionally we are shipping IRF5 Antibodies (141) and IRF5 Kits (15) and many more products for this protein. A total of 185 IRF5 products are currently listed.
Synonyms:
AW491843, im:7155364, irf5, mirf5, SLEB10, zgc:76986
list all proteins Gene Name GeneID UniProt
IRF5 3663 Q13568
IRF5 27056 P56477
Rat IRF5 IRF5 296953  

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IRF5 Proteins (IRF5) by Origin

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Human Interferon Regulatory Factor 5 (IRF5) interaction partners

  1. IRF5 and PADI4 significantly discriminated between RA patients and healthy controls in LDA.

  2. IRF5 and IRF8 (show IRF8 Proteins), two transcription factors with opposing functions, control TLR9 (show TLR9 Proteins) signaling in human plasmacytoid dendritic cells.

  3. meta-analysis demonstrated the IRF5 rs2070197 polymorphism conferred susceptibility to systemic lupus erythematosus (SLE) in all subjects without inter-study heterogeneity; IRF5 rs2070197 polymorphism was identified as risk factors for SLE in Caucasian populations but it had no effects in Asians

  4. Genetic associations and gene-gene interactions of IRF5 and TYK2 were significantly detected in Han Chinese with systemic lupus erythematosus

  5. four single nucleotide polymorphisms studied in IRF5 may affect neither Neuromyelitis optica nor Multiple sclerosis in the Southeastern Han Chinese population

  6. h Epstein-Barr virus and Mycobacterium avium subsp. paratuberculosis epitopes of IRF5 elicit a consistent humoral response in multiple sclerosis patients

  7. Study indicates that high-level IRF-5 expression is specific to HTLV-1-infected T cells and regulated by Tax (show CNTN2 Proteins) viral protein.

  8. the data demonstrate a critical mechanism by which sex differences in basal plasmacytoid dendritic cell IRF5 expression lead to higher IFN-alpha (show IFNA Proteins) production upon TLR7 (show TLR7 Proteins) stimulation in females.

  9. regulates CXCL13 (show CXCL13 Proteins)-mediated recruitment of B and T cells to IRF5-positive tumor-conditioned media

  10. The polymorphisms in the IRF5 gene may play a role in the development of Crohn's Disease in the Malaysian population, as seen in the significant associations of SNPs, that is, rs3807306, rs10954213 and rs11770589.

Mouse (Murine) Interferon Regulatory Factor 5 (IRF5) interaction partners

  1. data suggest that IRF5 plays a causal role in inflammation, fibrosis and impaired vascular EC function in Tsk (show FBN1 Proteins)/+ mice

  2. study sheds light on the TLR4 (show TLR4 Proteins)-IRF5 pathway in the pathology of SSc (show CYP11A1 Proteins) with clinical implications of targeting the IRF5 pathways in the suppression of disease development

  3. Collectively, these results indicate a key role for IRF-5 in modulating the host antiviral response in peripheral organs that controls bunyavirus neuroinvasion in mice.

  4. studies extend prior ones suggesting that inhibiting IRF5 might be useful for chronic macrophage-induced inflammation and suggest that IRF5 blockade would ameliorate more acute forms of inflammation, including lung injury

  5. IRF5 plays an important role in the development of disease in the MRL/lpr (show FAS Proteins) mouse model of lupus in the absence of the DOCK2 mutation and that IRF5 is required for the transition from mature B cells to plasma cells.

  6. IRF5 expression in microglia is regulated by IRF8 (show IRF8 Proteins). IRF5 directly upregulates P2RX4 (show P2RX4 Proteins) expression on microglia in peripheral nerve injury, and may play a role in neuropathic pain.

  7. PAR1 (show F2R Proteins) suppression of IRF5 and IL-12 (show IL12A Proteins)/23 secretion by macrophages provides a novel mechanism by which the host suppresses the mucosal Th1 (show HAND1 Proteins) and Th17 response to H. pylori infection.

  8. This study uncovers a new function for IRF5 in controlling the relative mass of different adipose tissue depots and thus insulin (show INS Proteins) sensitivity in obesity.

  9. IKKbeta (show IKBKB Proteins) is an IRF5 kinase that instigates inflammation

  10. our results reveal a protective role for IRF5 in lupus-associated atherosclerosis that is mediated through the effects of IRF5 in both immune and nonimmune cells.

IRF5 Protein Profile

Protein Summary

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment.

Alternative names and synonyms associated with IRF5

  • interferon regulatory factor 5 (IRF5)
  • interferon regulatory factor 5 (irf5)
  • Interferon regulatory factor 5 (irf5)
  • interferon regulatory factor 5 (LOC100350244)
  • interferon regulatory factor 5 (Irf5)
  • AW491843 protein
  • im:7155364 protein
  • irf5 protein
  • mirf5 protein
  • SLEB10 protein
  • zgc:76986 protein

Protein level used designations for IRF5

interferon regulatory factor 5 , Interferon regulatory factor 5 , interferon regulatory factor 5-like , IRF-5 , interferon regulatory factor 5 bone marrow

GENE ID SPECIES
472512 Pan troglodytes
700725 Macaca mulatta
734065 Xenopus (Silurana) tropicalis
100071786 Equus caballus
100194823 Salmo salar
100350244 Oryctolagus cuniculus
100396202 Callithrix jacchus
100596283 Nomascus leucogenys
3663 Homo sapiens
27056 Mus musculus
296953 Rattus norvegicus
482264 Canis lupus familiaris
615340 Bos taurus
405811 Danio rerio
494760 Xenopus laevis
430409 Gallus gallus
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