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Human IRF5 Protein expressed in HEK-293 Cells - ABIN2723539
Griesbeck, Ziegler, Laffont, Smith, Chauveau, Tomezsko, Sharei, Kourjian, Porichis, Hart, Palmer, Sirignano, Beisel, Hildebrandt, Cénac, Villani, Diefenbach, Le Gall, Schwartz, Herbeuval, Autran et al.: Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women. ... in Journal of immunology (Baltimore, Md. : 1950) 2015
Data suggest that IRAK4 (show IRAK4 Proteins) activity regulates activation of IRF5, TAK1 (show MAP3K7 Proteins), and IKKB (show IKBKB Proteins) in monocytes; IRAK4 (show IRAK4 Proteins) activation of TAK1 (show MAP3K7 Proteins)-IKKB (show IKBKB Proteins)-IRF5 axis leads to induction of cytokines and interferons following TLR7 (show TLR7 Proteins)/TLR8 (show TLR8 Proteins) stimulation. (IRAK4 (show IRAK4 Proteins) = interleukin-1 receptor-associated kinase 4 (show IRAK4 Proteins); IRF5 = interferon regulatory factor-5; TAK1 (show MAP3K7 Proteins) = MAPK (show MAPK1 Proteins) kinase kinase 7; IKKB (show IKBKB Proteins) = I-kappa B kinase; TLR = toll (show TLR4 Proteins)-like receptor)
IRF5 and IRF5 disease-risk variants increase glycolysis and human m1 macrophage polarization by regulating proximal signaling and Akt2 (show AKT2 Proteins) activation.
the genomic pattern according to MATH demonstrated that mutation rates of TP53, IRF5 and KRAS were independently associated with MATH, and the latter two were only significant in male patients. As MATH increased, the fraction of somatic copy number alteration (SCNA) elevated. Moreover, more SCNA events was independently associated with MATH in male than in female
IRF-5 targeted the expression of vascular cell adhesion molecule 1 (VCAM-1 (show VCAM1 Proteins)) at the transcriptional level by binding to its promoter.
oncogenic IRF5 overexpression in HL is the result of a specific LTR transcriptional activation
the primary activating regulatory region of human IRF5 was located in its minimal promoter region between nucleotides -179 and +62. In addition, it was shown that Sp1 (show PSG1 Proteins) was able to bind to the multiple sites in IRF5 promoter region, and was involved in the transcriptional regulation of IRF5 at the basal level.
This study demonstrates the association of IRF5 with an increased susceptibility for systemic lupus erythematosus (SLE) in the population of Crete and emphasizes the association of the Neanderthal-derived IRF5 haplotype with SLE susceptibility. Patients carrying allele the Neanderthal allele C had greater type I IFN, supporting a functional consequence of this polymorphism.
this study shows that IRF5 polymorphisms are associated with unexplained recurrent pregnancy loss among Iranian women
The results demonstrated that STAT4 (show STAT4 Proteins) rs7574865 and IRF5 rs2004640G/T substitution are associated with a susceptibility to systemic sclerosis.
Data suggest that interferon beta (IFN-beta (show IFNB1 Proteins)) might be involved in modulating the expressions of interferon regulatory factor 1 (IRF1 (show IRF1 Proteins)) and interferon regulatory factor-5 protein (IRF5) as well as maintaining the M1 polarization status and its function.
BCG (show SLC11A1 Proteins) increased membrane expression of TRIM59 through the TLR2/ TLR4 (show TLR4 Proteins)/IRF5 pathway in RAW264.7 macrophage cell line.
these results reveal a role for Lyn (show LYN Proteins) as a specific suppressor of the TLR-MyD88 (show MYD88 Proteins)-IRF5 pathway and illustrate the importance of fine-tuning IRF5 activity for the maintenance of immune homeostasis
IRF5 siRNA reverses pancreatitis-induced activation of lung macrophages from M1 phenotype to M2 phenotype in severe acute pancreatitis associated with acute lung injury.
Our data show that miR (show MLXIP Proteins)-146b targets IRF5, resulting in the regulation of macrophage activation. Furthermore, miR (show MLXIP Proteins)-146b deficient mice developed intestinal inflammation with enhanced M1 macrophage polarization.
data suggest that IRF5 plays a causal role in inflammation, fibrosis and impaired vascular EC function in Tsk (show FBN1 Proteins)/+ mice
study sheds light on the TLR4 (show TLR4 Proteins)-IRF5 pathway in the pathology of SSc (show CYP11A1 Proteins) with clinical implications of targeting the IRF5 pathways in the suppression of disease development
Collectively, these results indicate a key role for IRF-5 in modulating the host antiviral response in peripheral organs that controls bunyavirus neuroinvasion in mice.
studies extend prior ones suggesting that inhibiting IRF5 might be useful for chronic macrophage-induced inflammation and suggest that IRF5 blockade would ameliorate more acute forms of inflammation, including lung injury
IRF5 plays an important role in the development of disease in the MRL/lpr (show FAS Proteins) mouse model of lupus in the absence of the DOCK2 mutation and that IRF5 is required for the transition from mature B cells to plasma cells.
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment.
interferon regulatory factor 5
, Interferon regulatory factor 5
, interferon regulatory factor 5-like
, interferon regulatory factor 5 bone marrow