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Human IRF5 Protein expressed in HEK-293 Cells - ABIN2723539
Griesbeck, Ziegler, Laffont, Smith, Chauveau, Tomezsko, Sharei, Kourjian, Porichis, Hart, Palmer, Sirignano, Beisel, Hildebrandt, Cénac, Villani, Diefenbach, Le Gall, Schwartz, Herbeuval, Autran et al.: Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women. ... in Journal of immunology (Baltimore, Md. : 1950) 2015
the primary activating regulatory region of human IRF5 was located in its minimal promoter region between nucleotides -179 and +62. In addition, it was shown that Sp1 (show PSG1 Proteins) was able to bind to the multiple sites in IRF5 promoter region, and was involved in the transcriptional regulation of IRF5 at the basal level.
This study demonstrates the association of IRF5 with an increased susceptibility for systemic lupus erythematosus (SLE) in the population of Crete and emphasizes the association of the Neanderthal-derived IRF5 haplotype with SLE susceptibility. Patients carrying allele the Neanderthal allele C had greater type I IFN, supporting a functional consequence of this polymorphism.
this study shows that IRF5 polymorphisms are associated with unexplained recurrent pregnancy loss among Iranian women
The results demonstrated that STAT4 (show STAT4 Proteins) rs7574865 and IRF5 rs2004640G/T substitution are associated with a susceptibility to systemic sclerosis.
Data suggest that interferon beta (IFN-beta (show IFNB1 Proteins)) might be involved in modulating the expressions of interferon regulatory factor 1 (IRF1 (show IRF1 Proteins)) and interferon regulatory factor-5 protein (IRF5) as well as maintaining the M1 polarization status and its function.
IRF5 and PADI4 significantly discriminated between RA patients and healthy controls in LDA.
IRF5 and IRF8 (show IRF8 Proteins), two transcription factors with opposing functions, control TLR9 (show TLR9 Proteins) signaling in human plasmacytoid dendritic cells.
meta-analysis demonstrated the IRF5 rs2070197 polymorphism conferred susceptibility to systemic lupus erythematosus (SLE) in all subjects without inter-study heterogeneity; IRF5 rs2070197 polymorphism was identified as risk factors for SLE in Caucasian populations but it had no effects in Asians
Genetic associations and gene-gene interactions of IRF5 and TYK2 were significantly detected in Han Chinese with systemic lupus erythematosus
four single nucleotide polymorphisms studied in IRF5 may affect neither Neuromyelitis optica nor Multiple sclerosis in the Southeastern Han Chinese population
IRF5 siRNA reverses pancreatitis-induced activation of lung macrophages from M1 phenotype to M2 phenotype in severe acute pancreatitis associated with acute lung injury.
Our data show that miR (show MLXIP Proteins)-146b targets IRF5, resulting in the regulation of macrophage activation. Furthermore, miR (show MLXIP Proteins)-146b deficient mice developed intestinal inflammation with enhanced M1 macrophage polarization.
data suggest that IRF5 plays a causal role in inflammation, fibrosis and impaired vascular EC function in Tsk (show FBN1 Proteins)/+ mice
study sheds light on the TLR4 (show TLR4 Proteins)-IRF5 pathway in the pathology of SSc (show CYP11A1 Proteins) with clinical implications of targeting the IRF5 pathways in the suppression of disease development
Collectively, these results indicate a key role for IRF-5 in modulating the host antiviral response in peripheral organs that controls bunyavirus neuroinvasion in mice.
studies extend prior ones suggesting that inhibiting IRF5 might be useful for chronic macrophage-induced inflammation and suggest that IRF5 blockade would ameliorate more acute forms of inflammation, including lung injury
IRF5 plays an important role in the development of disease in the MRL/lpr (show FAS Proteins) mouse model of lupus in the absence of the DOCK2 mutation and that IRF5 is required for the transition from mature B cells to plasma cells.
IRF5 expression in microglia is regulated by IRF8 (show IRF8 Proteins). IRF5 directly upregulates P2RX4 (show P2RX4 Proteins) expression on microglia in peripheral nerve injury, and may play a role in neuropathic pain.
PAR1 (show F2R Proteins) suppression of IRF5 and IL-12 (show IL12A Proteins)/23 secretion by macrophages provides a novel mechanism by which the host suppresses the mucosal Th1 (show HAND1 Proteins) and Th17 response to H. pylori infection.
This study uncovers a new function for IRF5 in controlling the relative mass of different adipose tissue depots and thus insulin (show INS Proteins) sensitivity in obesity.
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment.
interferon regulatory factor 5
, Interferon regulatory factor 5
, interferon regulatory factor 5-like
, interferon regulatory factor 5 bone marrow