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Functions of the two zebrafish MAVS (show MAVS ELISA Kits) variants are opposite in the induction of IFN1 by targeting IRF7
The miR (show MYLIP ELISA Kits)-142a-3p regulates HSC (show FUT1 ELISA Kits) formation and differentiation through the repression of interferon regulatory factor 7 (irf7)-mediated inflammation signaling.
MyD88 (show MYD88 ELISA Kits) interacts with interferon (show IFNA ELISA Kits) regulatory factor (IRF) 3 (show IRF3 ELISA Kits) and IRF7 in Atlantic salmon (Salmo salar)
Differences in transcription kinetics between IRF-7 and STAT1 (show STAT1 ELISA Kits) indicate that genes are regulated through different pathways. Infection of TO cells with ISAV induced early synthesis of STAT1 (show STAT1 ELISA Kits) mRNA, whereas IRF-7 transcripts were upregulated later.
Human IRF7 was shown to be essential for interferon (show IFNA ELISA Kits) type I-dependent protective immunity against primary influenza. (Review)
The IRF7 GG genotype associate with Cognitive Decline and Dementia.
IRF7 cleavage by the 3C protease of enterovirus D68 abrogated its capacity to activate type I interferon (show IFNA ELISA Kits) expression and limit virus replication.
Viral infection induced DAPK1 (show DAPK1 ELISA Kits)-IRF7 and DAPK1 (show DAPK1 ELISA Kits)-IRF3 (show IRF3 ELISA Kits) interactions and overexpression of DAPK1 (show DAPK1 ELISA Kits) enhanced virus-induced activation of the interferon (show IFNA ELISA Kits)-stimulated response element (ISRE) and IFN-beta (show IFNB1 ELISA Kits) promoters and the expression of the IFNB1 (show IFNB1 ELISA Kits) gene.
Interferon regulatory factor 7 (IRF7) is a direct target of miR (show MLXIP ELISA Kits)-762 and overexpression of miR (show MLXIP ELISA Kits)-762 reduced expression of IRF7.
Data indicate that the type-I interferon (show IFNA ELISA Kits) master regulator gene interferon regulatory factor 7 (IRF7) is only hypomethylated in lupus patients with renal involvement.
our results indicate that IRF7 promotes glioma cell invasion and both chemoresistance and radioresistance through AGO2 (show EIF2C2 ELISA Kits) inhibition
The interaction between AIP (show AIP ELISA Kits) and IRF7 is enhanced upon virus infection, and AIP (show AIP ELISA Kits) potently inhibits IRF7-induced type I IFN (IFN-alpha/beta) production.
Authors found that knockdown of IRF7 leads to growth inhibition of Epstein-Barr virus-transformed cells, and restoration of IRF7 by exogenous plasmid correlates with growth recovery of the viral transformed cells.
In TSC2 (show TSC2 ELISA Kits)-deficient angiomyolipoma patient cells, IRF7 is a pivotal factor in the Rheb (show RHEB ELISA Kits)/mTOR (show FRAP1 ELISA Kits) pathway.
poly I:C augments IFN-gamma-induced (show SAMHD1 ELISA Kits) NO production at the transcriptional level via enhanced IRF7 activation
IRF7 protects against vascular smooth muscle cell proliferation.
Data showed that expression of interferon regulatory factor 7 (IRF7) increased during the M2-like to M1-like switch in microglia in vitro and in vivo.
Data suggest that Trim35 (tripartite motif-containing 35 (show TRIM35 ELISA Kits)) down-regulates type I interferon (show IFNA ELISA Kits) production in dendritic cells via toll (show TLR4 ELISA Kits)-like receptors 7/9 and down-regulates stability of Irf7 (interferon regulatory factor 7) via ubiquitination/proteasomes.
Authors show that the capacity to undergo pro- to anti-inflammatory (M1-to-M2) phenotype switch is controlled by the transcription factor interferon regulatory factor 7 (IRF7) that is down-regulated by the TGFbeta1 (show TGFB1 ELISA Kits) pathway.
Our data highlight a pivotal role of CCL7 (show CCL7 ELISA Kits) and IRF-7 in rhinovirus-induced inflammation
These results establish a dominant protective role for MAVS (show MAVS ELISA Kits), IRF-3 (show IRF3 ELISA Kits) and IRF-7, and IFNAR (show IFNAR1 ELISA Kits) in restricting Oropouche virus infection and tissue injury and suggest that IFN signaling in nonmyeloid cells contributes to the host defense.
IRF7 suppresses antiparasitic immunity in the spleen, while IFNAR1 (show IFNAR1 ELISA Kits)-mediated, but IRF7-independent, signaling contributes to pathology in the brain during experimental blood-stage malaria.
IRF-3 (show IRF3 ELISA Kits), IRF-7, and IPS-1 (show ISYNA1 ELISA Kits) promote host defense against acute human metapneumovirus infection in neonatal mice
IRF7 acts as a novel negative regulator of pathological cardiac hypertrophy by inhibiting nuclear factor-kappaB signaling and may constitute a potential therapeutic target for pathological cardiac hypertrophy.
Expression of porcine fusion protein IRF7/3(5D) efficiently controls foot-and-mouth disease virus replication.
N(pro) of classical swine fever virus (CSFV) interacts with IRF7; Zn-binding domain of N(pro) is essential for the interaction; results show CSFV N(pro) is capable of manipulating function of IRF7 in plasmacytoid dendritic cells
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.
interferon regulatory factor 7
, interferon regulatory factor 7-like
, interferon regulatory factor-7H
, interferon regulatory factor-7