Browse our TAB1 Proteins (TAB1)

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TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 Proteins (TAB1)
On are 7 TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) Proteins from 5 different suppliers available. Additionally we are shipping TAB1 Antibodies (185) and TAB1 Kits (5) and many more products for this protein. A total of 208 TAB1 products are currently listed.
3'-Tab1, 2310012M03Rik, b2b449Clo, Map3k7ip1
list all proteins Gene Name GeneID UniProt
TAB1 10454 Q15750
TAB1 66513 Q8CF89
Rat TAB1 TAB1 315139  

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TAB1 Proteins (TAB1) by Origin

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More Proteins for TAB1 Interaction Partners

Human TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) interaction partners

  1. we show that IL-1 (show IL1A Proteins) induces robust p38a (show MAPK14 Proteins) activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a (show MAPK14 Proteins) activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 (show DUSP1 Proteins) through a negative feedback to pp38, its basal activity is controlled by both TAB1 and MKP1 (show DUSP1 Proteins) through a positive feedback loop.

  2. TAK1 (show MAP3K7 Proteins)/TAB1 expression in non-small cell lung carcinoma tissue is significantly increased and closely associated with patient clinical prognosis.

  3. miR (show MLXIP Proteins)-29a repressed TAB1-mediated TIMP-1 (show TIMP1 Proteins) production in dermal fibroblasts, demonstrating that miR (show MLXIP Proteins)-29a may be a therapeutic target in SSc (show CYP11A1 Proteins).

  4. Data indicate that mitogen-activated protein kinase (show MAPK1 Proteins) (MAPK) p38 (show MAPK1 Proteins) activation is triggered by AMP (show APRT Proteins)-activated protein kinases (AMPK (show PRKAA1 Proteins)) and mediated by TAB1 protein.

  5. The amino acid sequence between positions 373 and 502 of TAB1 is required for TP interaction.

  6. USP18 (show USP18 Proteins) inhibits NF-kappaB (show NFKB1 Proteins) and NFAT (show NFATC1 Proteins) activation during Th17 differentiation by deubiquitinating the TAK1 (show MAP3K7 Proteins)-TAB1 complex.

  7. We found that endothelial TAK1 (show MAP3K7 Proteins) and TAB2 (show TAB2 Proteins), but not TAB1, were critically involved in vascular formation

  8. TAK1 (show MAP3K7 Proteins) plays a critical role in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation.

  9. data suggest a complex role of aa 452-457 of TAB1 in controlling p38 MAPK (show MAPK14 Proteins) activity and subcellular localization and implicate these residues in TAK1 (show MAP3K7 Proteins)- or p38 MAPK (show MAPK14 Proteins)-dependent post-transcriptional control of gene expression

  10. Phosphorylation and polyubiquitination of TAK1 (show MAP3K7 Proteins) are necessary for activation of NF-kappaB (show NFKB1 Proteins) by the Kaposi's sarcoma-associated herpesvirus vGPCR.

Mouse (Murine) TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) interaction partners

  1. our study uncovers that RNF114 (show RNF114 Proteins)-mediated ubiquitination and degradation of TAB1 activate the NF-kappaB (show NFKB1 Proteins) pathway during MZT, and thus directly link maternal clearance to early embryo development.

  2. We confirmed that PGC (show PGC Proteins)-1b inhibited downstream inflammatory signals via binding with TAB1 and thus preventing TAB1/TAK1 (show NR2C2 Proteins) binding and TAK1 (show NR2C2 Proteins) activation.

  3. The E3 ubiquitin ligase (show MUL1 Proteins) Itch inhibits p38alpha (show MAPK14 Proteins) signaling and skin inflammation through the ubiquitylation of Tab1.

  4. TAB1 and TAB2 (show TAB2 Proteins) are required for activated macrophages, making TAB1 and TAB2 (show TAB2 Proteins) effective targets to control inflammation by modulating macrophage survival.

  5. Both the MEKK1 (show MAP2K1 Proteins) PHD (show PDC Proteins) and TAB1 are critical for ES-cell differentiation

  6. The enhanced JNK (show MAPK8 Proteins) and IkappaB kinase (show CHUK Proteins) activation in DUSP14 (show DUSP14 Proteins)-deficient T cells was attenuated by TAB1 short hairpin RNA knockdown.

  7. TAB1 binding stabilizes active p38alpha (show MAPK14 Proteins) and induces rearrangements within the activation segment by helical extension of the Thr (show TRH Proteins)-Gly-Tyr (show TYR Proteins) motif, allowing autophosphorylation in cis (show CISH Proteins)

  8. We found that endothelial TAK1 (show NR2C2 Proteins) and TAB2 (show TAB2 Proteins), but not TAB1, were critically involved in vascular formation

  9. O-GlcNAcylation of TAB1 is required for full TAK1 (show NR2C2 Proteins) activation upon stimulation with IL-1 (show IL1A Proteins)/osmotic stress.

  10. Epithelial TAK1 (show NR2C2 Proteins) activity is regulated through two unique, TAB1-dependent basal & TAB2 (show TAB2 Proteins)-mediated stimuli-dependent mechanisms.

TAB1 Protein Profile

Protein Summary

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with TAB1

  • TGF-beta activated kinase 1/MAP3K7 binding protein 1 (TAB1)
  • TGF-beta activated kinase 1/MAP3K7 binding protein 1 (Tab1)
  • 3'-Tab1 protein
  • 2310012M03Rik protein
  • b2b449Clo protein
  • Map3k7ip1 protein

Protein level used designations for TAB1

TAK1-binding protein 1 , TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 , mitogen-activated protein kinase kinase kinase 7-interacting protein 1 , transforming growth factor beta-activated kinase-binding protein 1 , TGF-beta-activated kinase 1-binding protein 1 , Tak1-binding protein 1 , beta activated kinase-1 binding protein-1 , mitogen activated protein kinase kinase kinase 7 interacting protein 1 , mitogen-activated protein kinase kinase kinase 7 interacting protein 1

10454 Homo sapiens
66513 Mus musculus
315139 Rattus norvegicus
100358246 Oryctolagus cuniculus
418014 Gallus gallus
481245 Canis lupus familiaris
519958 Bos taurus
100153785 Sus scrofa
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