TAB1 Products
(TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))
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The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Featured TAB1 Categories
TAB1 Antibodies
High quality antibodies with extensive validation data.
TAB1 ELISA Kits
Reliable ELISA kits for a wide range of species.
TAB1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TAB1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
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Reactivity
Human
Application
WB, ELISA, IF, PLA
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- (6)
Cat. No.
ABIN564552
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (4)
Cat. No.
ABIN7171965
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN523851
Quantity
200 μL
Datasheet
Datasheet
Recommended TAB1 ELISA Kits
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Reactivity
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Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
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Cat. No.
ABIN6970603
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6229502
Quantity
96 tests
Datasheet
Datasheet
Recommended TAB1 Proteins
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Reactivity
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Source
Escherichia coli (E. coli)
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Cat. No.
ABIN7125344
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310231
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310229
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our TAB1 products
: "MicroRNA 27a-3p Regulates Antimicrobial Responses of Murine Macrophages Infected by Mycobacterium avium subspecies paratuberculosis by Targeting Interleukin-10 and TGF-β-Activated Protein Kinase 1 ..." in: Frontiers in immunology, Vol. 8, pp. 1915, (2017) (PubMed).: "Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates." in: The Journal of biological chemistry, Vol. 287, Issue 19, pp. 15395-408, (2012) (PubMed).
: "PRAK is essential for ras-induced senescence and tumor suppression." in: Cell, Vol. 128, Issue 2, pp. 295-308, (2007) (PubMed).
: "Determinants that control the specific interactions between TAB1 and p38alpha." in: Molecular and cellular biology, Vol. 26, Issue 10, pp. 3824-34, (2006) (PubMed).
: "TAK1-binding protein 1 is a pseudophosphatase." in: The Biochemical journal, Vol. 399, Issue 3, pp. 427-34, (2006) (PubMed).
: "Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex ..." in: The Journal of biological chemistry, Vol. 280, Issue 8, pp. 7359-68, (2005) (PubMed).
: "Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice." in: Cancer research, Vol. 64, Issue 20, pp. 7183-90, (2004) (PubMed).
: "Toll-like receptor signalling." in: Nature reviews. Immunology, Vol. 4, Issue 7, pp. 499-511, (2004) (PubMed).
: "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2." in: Nature, Vol. 416, Issue 6878, pp. 345-7, (2002) (PubMed).
: "Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol." in: Molecular and cellular biology, Vol. 22, Issue 20, pp. 7158-67, (2002) (PubMed).
Synonyms and alternative names related to TAB1
TGF-beta activated kinase 1 (MAP3K7) binding protein 1 (TAB1), TGF-beta activated kinase 1/MAP3K7 binding protein 1 (Tab1), 3'-Tab1, 2310012M03Rik, b2b449Clo, MAP3K7IP1, Map3k7ip1Protein level used designations for TAB1
- TAK1-binding protein 1
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- mitogen-activated protein kinase kinase kinase 7-interacting protein 1
- transforming growth factor beta-activated kinase-binding protein 1
- TGF-beta-activated kinase 1-binding protein 1
- Tak1-binding protein 1
- beta activated kinase-1 binding protein-1
- mitogen activated protein kinase kinase kinase 7 interacting protein 1
- mitogen-activated protein kinase kinase kinase 7 interacting protein 1
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