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TLR7 and TLR8 (show TLR8 Proteins) genetic polymorphisms are associated with susceptibility to mycobacterium tuberculosis infection, and the link is shaped by less effective MTB (show NCAPG2 Proteins) phagocytosis and impaired TLR signaling.
Study evaluated innate immune profiles following TLR stimulation in HIV-1-infected mothers and newborns, found significantly compromised cytokine responses upon extracellular and intracellular TLR activation. Myeloid dendritic cell (DC) responsiveness appeared to be less impaired than plasmacytoid DCs, and might be enhanced through TLR7/TLR8 (show TLR8 Proteins) activation.
This is the first study illustrating certain genotypes of TLR-7 and TLR-8 (show TLR8 Proteins) single nucleotide polymorphisms viz. CT(p = 0.002)]; rs3853839[GC(p < 0.001), CC(p = 0.039)] and rs3764879[GC(p < 0.001)] were considerably associated with Chikungunya virus susceptibility.
study demonstrates that activation of TLR7 signaling in T cells can inhibit Th17 cell differentiation from naive T cells and IL-17 (show IL17A Proteins) production in established Th17 cells; further report that downregulation of STAT3 (show STAT3 Proteins) signaling is responsible for TLR7-mediated inhibition of Th17 cells due to induction of suppressor of cytokine signaling 3 (show SOCS3 Proteins) and 5
Data indicate a mechanism in which Toll (show TLR4 Proteins)-like receptors TLR7/8 signaling, through shedding of FcgRIIA, shifts neutrophil function from phagocytosis to a programmed necrosis pathway, neutrophil extracellular trap formation (NETosis).
TLR7 is abundantly expressed in human atherosclerotic plaques. TLR7 ligation elicits the secretion of pro-inflammatory and anti-inflammatory cytokines, and high TLR7 expression in plaques is associated with better patient outcome.
this study identified TLR7 as mediator of monocyte differentiation and M2 macrophage polarization during hepatitis C virus infection
Increased susceptibility to autoimmune is associated with single nucleotide polymorphisms and copy number variations of Toll like receptor 7. [review]
COPD (show ARCN1 Proteins) lung tissue explants showed a greater pro-inflammatory response to TLR3 (show TLR3 Proteins) or TLR7/8 activation than control smokers.
combination adjuvant systems demonstrate markedly different immune activation with age, with combined DC activation via Macrophage-inducible C-type lectin (show CLEC4E Proteins) and TLR7/8 representing a novel approach to enhance the efficacy of early-life vaccines.
Virus infection activates endosomal NOX2 (show CYBB Proteins) oxidase and restricts TLR7 signaling, and that an endosomal NOX2 (show CYBB Proteins) inhibitor decreases viral pathogenicity.
the JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) pathway provides a cytokine rheostat mechanism, which enables macrophages to fine-tune their responses to multiple, temporally separated infection events involving the TLR3 (show TLR3 Proteins) and TLR7 pathways.
TLR7 deficiency attenuates retinal damage in diabetic retinopathy model.
The data demonstrate that an atypical TLR7 signaling pathway contributes to type interferon-beta (show IFNB1 Proteins) expression during Y. pestis infection and suggest that the TLR7-driven type I IFN response plays an important role in determining the outcome of plague.
Evaluation of the adjuvant effect of agonists of toll-like receptor 4 (show TLR4 Proteins) and 7/8 in a vaccine against leishmaniasis
these data demonstrate that extracellular-miRNA mimics (miR (show MLXIP Proteins)-34a, -122, -133a, -142, -146a, and -208a) are potent innate immune activators and that the miRNAs most likely induce cytokine production and leukocyte migration through TLR7 signaling
Notch1-Hes-1 signaling controls TLR7-induced autophagic death of macrophage via regulation of P62 in mice with lupus.
Dual TLR2/TLR7 agonist induced the maturation of dendritic cells and primed substantial populations of cytolytic and highly polyfunctional effector CD8 (show CD8A Proteins)(+) T cells in vitro, and safely potentiated the immunogenic properties of a nanoparticulate Ag in vivo, eliciting humoral responses with a balanced TH1 (show HAND1 Proteins)/TH2 profile in mice.
determine the effects of a loss of autophagy in dendritic cells (DCs), as well as both B cells and DCs, in a TLR7-mediated model of autoimmunity, similar to systemic lupus erythematosus, where both cell types are critical for disease
TLR7 stimulation of Bovine Viral Diarrhea Virus Type 2-infected monocyte-derived macrophages induced cytokine secretion, unlike results observed for other Toll (show TLR4 Proteins)-Like Receptors.
The results from this study demonstrate that expression of at least TLR3 (show TLR3 Proteins), TLR7 and TLR8 (show TLR8 Proteins) is stimulated upon bovine alpha-herpesvirus infection of the brain.
expression of TLR3 (show TLR3 Proteins), TLR7 and TLR9 (show TLR9 Proteins) in alveolar macrophages infected with different genotype 1 PRRSV strains
Porcine TLR7 and TLR8 (show TLR8 Proteins) genes from pig lymph node tissue, were cloned and characterized.
The messenger RNA sequences and exon/intron structures of Toll (show TLR4 Proteins)-like receptors 3, 7, and 8 were determined.
A total of 22 polymorphic sites were observed in TLR7 gene of 24 goats representing 12 different breeds, out of which 19 were present within the coding region and three in 3'UTR.
Activation of Toll-like receptor 7 might prevent development of airway hyperresponsiveness by acting on the airway smooth muscle.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
toll-like receptor 7
, toll-like receptor 7-like
, toll like receptor 7
, toll-like receptor 7-long