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Considering that chronic hepatitis B infection is not yet curable, it could be possible to activate TLR7-related immunological pathways as a therapy directed towards persistent HBV infection
Both TLR 5 (show TLR5 Proteins) and 7 are expressed in salivary adenoid cystic carcinoma on the cell membranes as well as in cytoplasm.
human Toll-like receptor 7 ligand binding domain
TLR7 mRNA expression was significantly elevated in patients with relapsing remitting multiple sclerosis.
Our meta-analysis suggests that TLR7, TLR8 (show TLR8 Proteins), and TLR9 (show TLR9 Proteins) polymorphisms are associated with the development of systemic lupus erythematosus in Caucasian, Asian, and African populations
activation of TLR7 upregulated the expression levels of IFN-lambda1 and MMP-9 were increased by ~3 fold, whereas other genes (p53, PTEN, TIMP-1) were upregulated by ~2 fold, and VEGF was marginally upregulated after 10 min.
Increased expression of TLR7 and TLR9 (show TLR9 Proteins) in myasthenia gravis thymus is accompanied by active Epstein-Barr virus infection.
The low expression of TLR-7 in tumour and high expression of TLR-7 in stroma predict a good clinical outcome for oral squamous cell carcinoma patients
TLR7 and 8 polymorphisms may play a considerable role in the pathogenesis of asthma.
NADPH oxidase (show NOX1 Proteins)-deficient patient-derived B cells also expressed enhanced levels of TLR7 and TLR9 (show TLR9 Proteins) mRNA and protein compared with the same cells reconstituted to restore oxidase activity.
Orally administered R848 triggers TLR-7 on CD11c (show ITGAX Proteins)(+) dendritic cells, inducing interleukin-23 (IL-23 (show IL23A Proteins)) expression followed by a burst of IL-22 (show IL22 Proteins) secretion by innate lymphoid cells, leading to Reg3gamma expression and restoration of colonization resistance against vancomycin-resistant enterococcus.
The results imply that recognition of resident viruses by TLR3 (show TLR3 Proteins) and TLR7 is required for protective immunity during gut (show GUSB Proteins) inflammation.
pulmonary interstitial macrophages may not be a source of IL-33 (show IL33 Proteins) during Respiratory syncytial virus infection
Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8 (show CD8A Proteins)+ T Cells upon Stimulation with a TLR7 Ligand.
Type I Interferons maintain expression of TLR7 in B cells and conventional dendritic cells in different ways; total amount of TLR7 is kept in B cells and TLR7(+) population is retained among conventional dendritic cells.
TLR7/9-MyD88 (show MYD88 Proteins) might be important in the induction of neutrophils and the relevant inflammatory mediators in Bjerkandera adusta-Induced Lung Inflammation
These data provide direct evidence that B cells require TLR7-dependent priming through an autophagy-dependent mechanism before autoimmunity is induced, thereafter involving many cell types.
describe novel roles for type I IFN and TLR7 signaling in nonhematopoietic cells
Data show that preconditioning with poly(I:C) alters toll (show TLR4 Proteins)-like receptors (TLR) and RIG-I (show DDX58 Proteins)-like receptors (RLRs) responses in opposite directions.
Report chemical conjugation of TLR7 agonist T7 and multi-repeat-epitope of monoclonal gastric cancer 7 antigen exerts antitumor effects.
The results from this study demonstrate that expression of at least TLR3 (show TLR3 Proteins), TLR7 and TLR8 (show TLR8 Proteins) is stimulated upon bovine alpha-herpesvirus infection of the brain.
expression of TLR3 (show TLR3 Proteins), TLR7 and TLR9 (show TLR9 Proteins) in alveolar macrophages infected with different genotype 1 PRRSV strains
Porcine TLR7 and TLR8 (show TLR8 Proteins) genes from pig lymph node tissue, were cloned and characterized.
The messenger RNA sequences and exon/intron structures of Toll (show TLR4 Proteins)-like receptors 3, 7, and 8 were determined.
A total of 22 polymorphic sites were observed in TLR7 gene of 24 goats representing 12 different breeds, out of which 19 were present within the coding region and three in 3'UTR.
Activation of Toll-like receptor 7 might prevent development of airway hyperresponsiveness by acting on the airway smooth muscle.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.
toll-like receptor 7
, toll-like receptor 7-like
, toll like receptor 7
, toll-like receptor 7-long