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V-ATPases affecting the pH of the cytosol and intracellular compartments, particularly those containing a3, are also involved in invasion in breast cancer
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene.
ATPase, H+ transporting, lysosomal (vacuolar proton pump) subunit G3
, V-ATPase 13 kDa subunit 3
, V-ATPase G subunit 3
, V-ATPase G3 subunit
, V-ATPase subunit G 3
, V-type proton ATPase subunit G 3
, vacuolar ATP synthase subunit G 3
, vacuolar proton pump G subunit 3
, vacuolar proton pump subunit G 3
, vacuolar proton pump, subunit G3
, ATPase, H+ transporting, V1 subunit G