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Browse our ATP7B Proteins (ATP7B)

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ATPase, Cu++ Transporting, beta Polypeptide Proteins (ATP7B)
On are 11 ATPase, Cu++ Transporting, beta Polypeptide (ATP7B) Proteins from 4 different suppliers available. Additionally we are shipping ATP7B Antibodies (158) and ATP7B Kits (8) and many more products for this protein. A total of 181 ATP7B products are currently listed.
Atp7a, ATP7B, Hts, PINA, PWD, tx, WC1, Wd, WND
list all proteins Gene Name GeneID UniProt
ATP7B 540 P35670
ATP7B 11979 Q64446
Rat ATP7B ATP7B 24218  

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ATP7B Proteins (ATP7B) by Origin

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More Proteins for ATP7B Interaction Partners

Cow (Bovine) ATPase, Cu++ Transporting, beta Polypeptide (ATP7B) interaction partners

  1. Data show that CD4 (show CD4 Proteins)(+) and WC1(+) gammadelta T-cells were induced to produce IL-17 (show IL17A Proteins) termed Th17 and gammadelta17 cells.

  2. The endocytosis and signaling of the gamma-delta T cell coreceptor WC1 are regulated by a dileucine motif.

  3. WC1 is a hybrid gamma-delta TCR coreceptor and pattern recognition receptor for pathogenic bacteria.

  4. Identification of differences in the signal transduction through the endodomains of WC1 contributes to understanding the functional role of the WC1 coreceptors in the gammadelta T cell responses.

  5. Specific receptors in the WC1 family directly participate in Leptospira recognition and/or activation of gamma-delta T cells.

  6. These findings revealed that despite the existence of a distinct bovine CD4 (show CD4 Proteins)(+)CD25 (show IL2RA Proteins)(high) T cell population, which showed Foxp3 (show FOXP3 Proteins) transcription/expression, natural regulatory activity did not reside in this cell population

  7. Sudies demonstrate that WC1 molecules are encoded by a large, multi-gene family whose transcripts undergo extensive alternative splicing.

Human ATPase, Cu++ Transporting, beta Polypeptide (ATP7B) interaction partners

  1. ATP7B mutant cell lines showed different degrees of cell survival and characteristic responses upon treatment with Zn and D-penicillamine.

  2. Five of the nineteen mutations in ATP7B were newly detected mutations; moreover, 8 of these mutations were polymorphic (2 were newly identified).

  3. miR (show MLXIP Proteins)-133a enhances the sensitivity of multidrug-resistant epithelial cells to cisplatin by downregulating ATP7B expression.

  4. the identification of novel mutations in ATP7B for Wilson disease and hereditary hemochromatosis (HFE (show HFE Proteins)) or the non-HFE (show HFE Proteins) genes for HH has increased, especially with the application of whole genome sequencing technology in recent years, the biological function of the identified mutations, as well as genotype-phenotype correlations remain to be explored

  5. In the group of 75 Wilson Disease patients of Croatian origin, 18 different mutations in ATP7B gene were detected, three of which were novel. The p.His1069Gln mutation was most frequent, being detected in 44 Croatian WD patients (58.7%). Most ATP7B mutations (90.4%) were located in exons 5, 8, 13, 14, and 15.

  6. 24 ATP7B distinct mutations, seven of which are novel, have been found in 35 patients with hepatolenticular degeneration.

  7. With the capability of generating relatively higher throughput in a short time period, the NGS assay is a viable alternative to Sanger sequencing for detecting ATP7B mutations causally linked to Wilson disease in the clinical diagnostic laboratory

  8. analysis of the geographic distribution of ATP7B mutations in Wilson disease [review]

  9. Extrinsic expressing WT ATP7B reduced CuCl2-induced copper accumulation and enhanced cellular copper tolerance by accelerating copper excretion, which was selectively compromised by R778L and P992L mutations.

  10. Metal-dependent movement of the first four metal-binding domains in ATP7B may be a trigger that initiates the overall catalytic cycle.

Mouse (Murine) ATPase, Cu++ Transporting, beta Polypeptide (ATP7B) interaction partners

  1. Data indicate that the copper-transporting ATPase gene (Atp7b) knockout mice showed a drastic, time-dependent accumulation of hepatic copper.

  2. The aim of this study was to identify copper disturbances according to various brain compartments and further dissect the causal relationship between copper storage and neuronal damage using Atp7b(-/-) mice.

  3. DKWSLLL sequence is essential for ATP7b sorting at the TGN (show TG Proteins), transport from the TGN (show TG Proteins) to the PM, endocytosis, and recycling to the TGN (show TG Proteins) and PM.

  4. Ligand-activated nuclear receptors FXR/NR1H4 (show NR1H4 Proteins) and GR/NR3C1 (show NR3C1 Proteins) and nuclear receptor interacting partners are less abundant in Atp7b(-/-) hepatocyte nuclei.

  5. By performing dynamic PET, authors obtained the first real-time measurements of 64Cu distribution in the organs or tissues of Atp7b -/- mice.

  6. Clusterin (show CLU Proteins) and COMMD1 (show COMMD1 Proteins) independently regulate degradation of the mammalian copper ATPases ATP7A (show ATP7A Proteins) and ATP7B.

  7. Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease.

  8. The Jackson toxic milk mouse as a model for copper loading

  9. Both Atp7a (show ATP7A Proteins) and Atp7b are expressed in glomeruli; however, Atp7b is also seen in the kidney medulla suggesting that glomeruli are responsible for regulating copper levels in the filtrate

  10. Mice homozygous for the recessive txJ mutation examined at 6 months of age exhibited a reduced number of amyloid plaques and diminished plasma Abeta (show APP Proteins) levels. Homozygosity for txJ increased survival and lowered endogenous CNS Abeta (show APP Proteins).

Pig (Porcine) ATPase, Cu++ Transporting, beta Polypeptide (ATP7B) interaction partners

  1. A copper-dependent ATPase hydrolysis in a native Golgi-enriched preparation from liver, was characterized.

ATP7B Protein Profile

Protein Summary

This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).

Alternative names and synonyms associated with ATP7B

  • ATPase, Cu++ transporting, beta polypeptide (ATP7B)
  • ATPase, Cu++ transporting, beta polypeptide (atp7b)
  • ATPase, Cu++ transporting, beta polypeptide (Wilson disease) (atp7b)
  • ATPase, Cu++ transporting, beta polypeptide (LOC100344865)
  • ATPase, Cu++ transporting, beta polypeptide (Atp7b)
  • BoWC1.1 (WC1)
  • CD163 molecule-like 1 (CD163L1)
  • Atp7a protein
  • ATP7B protein
  • Hts protein
  • PINA protein
  • PWD protein
  • tx protein
  • WC1 protein
  • Wd protein
  • WND protein

Protein level used designations for ATP7B

ATPase, Cu++ transporting, beta polypeptide , copper-transporting ATPase beta subunit , ATPase, Cu++ transporting, beta polypeptide (Wilson disease) , Wilson's disease protein , copper-transporting ATPase , copper-transporting ATPase 2 , ATP7B-like , copper-transporting ATPase 2-like , ATPase, Cu(2+)- transporting, beta polypeptide , Wilson disease-associated protein , copper pump 2 , Wilson protein , toxic milk , wilson disease-associated protein homolog , ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease) , PINA gene, promoter , pineal night-specific ATPase , ATPase, Cu(2+)-transporting, beta polypeptide , ATPase 7B protein , scavenger receptor cysteine-rich type 1 protein M160 , scavenger-receptor protein

518075 Bos taurus
442967 Canis lupus familiaris
476903 Canis lupus familiaris
556499 Danio rerio
571325 Danio rerio
592143 Strongylocentrotus purpuratus
713781 Macaca mulatta
100344865 Oryctolagus cuniculus
100469748 Ailuropoda melanoleuca
100497797 Xenopus (Silurana) tropicalis
100028163 Monodelphis domestica
100082671 Ornithorhynchus anatinus
100052751 Equus caballus
100541545 Meleagris gallopavo
100558446 Anolis carolinensis
540 Homo sapiens
11979 Mus musculus
24218 Rattus norvegicus
418879 Gallus gallus
100049684 Sus scrofa
443046 Ovis aries
783109 Bos taurus
100144477 Sus scrofa
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