Browse our GDF2 Proteins (GDF2)

Full name:
Growth Differentiation Factor 2 Proteins (GDF2)
On are 20 Growth Differentiation Factor 2 (GDF2) Proteins from 9 different suppliers available. Additionally we are shipping GDF2 Antibodies (96) and GDF2 Kits (72) and many more products for this protein. A total of 193 GDF2 products are currently listed.
BMP-9, Bmp9, DSL1
list all proteins Gene Name GeneID UniProt
GDF2 2658 Q9UK05
GDF2 12165 Q9WV56
Rat GDF2 GDF2 290921  

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GDF2 Proteins (GDF2) by Origin

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Top referenced GDF2 Proteins

  1. Human GDF2 Protein expressed in CHO Cells - ABIN2666776 : Bidart, Ricard, Levet, Samson, Mallet, David, Subileau, Tillet, Feige, Bailly: BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain. in Cellular and molecular life sciences : CMLS 2012 (PubMed)
    Show all 8 references for 2666776

  2. Mouse (Murine) GDF2 Protein expressed in CHO Cells - ABIN2666778 : Herrera, Dooley, Breitkopf-Heinlein: Potential roles of bone morphogenetic protein (BMP)-9 in human liver diseases. in International journal of molecular sciences 2014 (PubMed)
    Show all 8 references for 2666778

More Proteins for GDF2 Interaction Partners

Human Growth Differentiation Factor 2 (GDF2) interaction partners

  1. Data suggest BMP9/GDF2 and BMP10 (show BMP10 Proteins) synergize with TNFA (show TNF Proteins) to increase monocyte recruitment to vascular endothelial cells; process appears to be mediated mainly via ALK2/ACVR1 (show ACRV1 Proteins) (which exhibits protein kinase (show CDK7 Proteins) activity). These studies used in vitro flow monocyte adhesion assay. (BMP9 = growth differentiation factor 2; BMP10 (show BMP10 Proteins) = bone morphogenetic protein 10 (show BMP10 Proteins); TNFA (show TNF Proteins) = tumor necrosis factor alpha (show TNF Proteins); ALK2/ACVR1 (show ACRV1 Proteins) = activin A receptor type 1 (show ACRV1 Proteins))

  2. These results suggest that BMP9-transduced calvarial mesenchymal progenitor cells seeded in a PPCN-g thermoresponsive scaffold is capable of inducing bone formation in vivo and is an effective means of creating tissue engineered bone for critical sized defects.

  3. circulating levels significantly decreased in type 2 diabetes mellitus patients and associated with glucose homoeostasis and insulin (show INS Proteins) sensitivity

  4. the data identify MxA (show MX1 Proteins) as a novel stimulator of BMP4 (show BMP4 Proteins) and BMP9 transcriptional signaling, and suggest it to be a candidate IFN-alpha (show IFNA Proteins)-inducible mechanism that might have a protective role against development of pulmonary arterial hypertension and other vascular diseases.

  5. BMP9 inhibited the proliferation and migration of the A549 cells.

  6. his study shows that BMP9 inhibition is associated with Osteosarcoma (OS) development and that enhanced expression of BMP9 may be a potential treatment method for OS

  7. IGF1 (show IGF1 Proteins) can enhance BMP9-induced osteogenic differentiation in mesenchymal stem cells.

  8. In ovarian and breast epithelial cells, epigenetic regulation of GDF2 suppresses anoikis.

  9. BMP9 also influenced the expression of PPARgamma (show PPARG Proteins).

  10. Data suggest ALK1 (show ACVRL1 Proteins) and ACVR2A (show ACVR2A Proteins)/ACVR2B (show ACVR2B Proteins), acting as BMP9 co-receptors, rearrange pro-domains of BMP9--pro-domain dimer complex leading to displacement of pro-domains after receptor binding, release of mature non-dimer BPM9, and activation of signaling.

Mouse (Murine) Growth Differentiation Factor 2 (GDF2) interaction partners

  1. Our findings provide a clearer understanding of the cellular pathways utilized by BMP-9 for chondrogenesis that may help improve current therapies for regenerative cartilage repair.

  2. Constitutive expression of low levels of BMP-9 stabilises hepatocyte function in the healthy liver. High levels of BMP-9 cause enhanced damage upon acute or chronic injury.

  3. Notch (show NOTCH1 Proteins) signaling may play an important role in BMP9-induced osteogenesis and angiogenesis. It's conceivable that simultaneous activation of the BMP9 and Notch (show NOTCH1 Proteins) pathways should efficiently couple osteogenesis and angiogenesis of MSCs for successful bone tissue engineering.

  4. Western blot analysis demonstrated that following BMP2 (show BMP2 Proteins) and BMP7 (show BMP7 Proteins) cotransfection of MC3T3E1 cells, the protein expression levels of BMP2 (show BMP2 Proteins), BMP4 (show BMP4 Proteins), BMP6 (show BMP6 Proteins), BMP7 (show BMP7 Proteins), BMP9 and Wnt3a (show WNT3A Proteins) were increased compared with control cells

  5. he results of the present study demonstrated that BMP9 promoted the osteoclast differentiation of osteoclast precursors via binding to the ALK1 receptor on the cell surface, and inhibiting the ERK1/2 signaling pathways in the cell

  6. that Dkk1 (show DKK1 Proteins) negatively regulates BMP9-induced osteogenic differentiation.

  7. Data show athat beta-catenin (show CTNNB1 Proteins) can be activated by bone morphogenetic protein 9 (BMP9) and the activation of beta-catenin (show CTNNB1 Proteins) plays an important role in the differentiation of C3H10T1/2 cells into cardiomyocyte-like cells induced by BMP9.

  8. miR23b inhibits BMP9induced C2C12 myoblast osteogenesis via targeting of the Runx2 (show RUNX2 Proteins) gene, acting as a suppressor.

  9. We have established a producer line that stably expresses a high level of active BMP9 protein. Such producer line should be a valuable resource for generating biologically active BMP9 protein for studying BMP9 signaling

  10. Data show that microRNA miR (show MLXIP Proteins)-21 was significantly upregulated by bone morphogenetic protein 9 (BMP9) during the osteogenesis the multilineage cells (MMCs) by suppressing Smad7 (show SMAD7 Proteins) protein.

GDF2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons.

Alternative names and synonyms associated with GDF2

  • growth differentiation factor 2 (gdf2)
  • growth differentiation factor 2 (GDF2)
  • growth differentiation factor 2 (Gdf2)
  • BMP-9 protein
  • Bmp9 protein
  • DSL1 protein

Protein level used designations for GDF2

bone morphogenetic protein 9 , GDF-2 , growth/differentiation factor 2 , BMP-9 , DSL-1 , dorsalin-1

563287 Danio rerio
2658 Homo sapiens
12165 Mus musculus
396412 Gallus gallus
540384 Bos taurus
290921 Rattus norvegicus
100351972 Oryctolagus cuniculus
100519741 Sus scrofa
611149 Canis lupus familiaris
101115426 Ovis aries
100723076 Cavia porcellus
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