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Browse our HFE Proteins (HFE)

Full name:
Hemochromatosis Proteins (HFE)
On are 15 Hemochromatosis (HFE) Proteins from 5 different suppliers available. Additionally we are shipping HFE Antibodies (73) and HFE Kits (1) and many more products for this protein. A total of 96 HFE products are currently listed.
list all proteins Gene Name GeneID UniProt
HFE 3077 Q30201
HFE 29199 O35799
HFE 15216 P70387

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HFE Proteins (HFE) by Origin

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Top referenced HFE Proteins

  1. Human HFE Protein expressed in Escherichia coli (E. coli) - ABIN1098722 : Feder, Penny, Irrinki, Lee, Lebrón, Watson, Tsuchihashi, Sigal, Bjorkman, Schatzman: The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 2 references for ABIN1098722

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Human Hemochromatosis (HFE) interaction partners

  1. In conclusion, our metaanalysis showed a marginal higher prevalence of H63D variant of the HFE gene in alcoholic liver disease but did not support an increased risk of C282Y mutation.

  2. HFE gene mutations are effective on iron deposition in the liver in sickle cell disease patients. In patients for whom recurrent erythrocyte transfusions are required, genotyping of the HFE gene will be helpful while management with chelating agents is being planned.

  3. The HFE genotype may predict myelodysplastic syndrome prognosis and there is a need for further studies. It remains a challenging question if HFE mutated myelodysplastic syndrome patients should be considered for potent iron chelation therapy.

  4. C282Y homozygotes referred for HFE testing commonly have a GNPAT (show GNPAT Proteins) variant. This GNPAT (show GNPAT Proteins) variant does not appear be a co-modifying gene affecting expression of HFE related hemochromatosis in this population. The GNPAT (show GNPAT Proteins) variant does not predict the severity of iron overload.

  5. In this study, HFE p.282Y variant (rs1800562 A allele) was significantly associated with the risk of varicose veins (OR 1.79, 95 % CI = 1.11-2.89, P = 0.02).

  6. Statistically significant differences were observed for genotype distribution of C282Y and H63D between the general population and the patients diagnosed with hereditary hemochromatosis.

  7. There are no relationship between these indexes and HFE gene C282Y mutation and either nonalcoholic fatty liver disease as a complication of diabetes.

  8. H63D HFE genetic carriers presented higher blood iron than wild-type probands.

  9. Data suggest that hereditary hemochromatosis (HH) due to mutations in HFE may be relatively asymptomatic in childhood as illustrated by diagnosis of HH in 10-year-old twin boys during investigation of cause of short stature/growth retardation in one of the boys; genetic testing revealed C282Y/H63D compound heterozygosity in HFE GENE. [CASE REPORT]

  10. Results suggest that HFE H63D polymorphism could represent a disease-modifying gene in frontotemporal lobar degeneration, fostering iron deposition in the basal ganglia

Mouse (Murine) Hemochromatosis (HFE) interaction partners

  1. unlike homozygous Hfe deletion, heterozygous gene deletion disrupted glucose homeostasis but did not affect lipid metabolism or liver injury.

  2. Single Hjv (show HFE2 Proteins)(-)/(-) and double Hfe(-)/(-)Hjv (show HFE2 Proteins)(-)/(-) mice exhibit comparable iron overload. Hfe and Hjv (show HFE2 Proteins) regulate hepcidin (show HAMP Proteins) via the same pathway.

  3. Results show that HFE requires HJV (show HFE2 Proteins) to activate downstream signal transduction pathways for hepcidin (show HAMP Proteins) regulation.

  4. Alterations in cholesterol metabolism associated with expression of H63D-HFE may contribute to the development of AD.

  5. results provide evidence that HFE induces hepcidin (show HAMP Proteins) expression via the BMP pathway: HFE interacts with ALK3 (show BMPR1A Proteins) to stabilize ALK3 (show BMPR1A Proteins) protein and increase ALK3 (show BMPR1A Proteins) expression at the cell surface.

  6. These results support in vivo studies which suggest that Hfe and Tfr2 (show TFR2 Proteins) can independently regulate hepcidin (show HAMP Proteins).

  7. A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice.

  8. Hfe-knockout mice did not have higher brain iron levels than wildtype controls.

  9. Hfe(-/-) retinal pigment epithelial cells exhibited slower senescence rate and higher survivin (show BIRC5 Proteins) expression than wild type cells. Hfe(-/-) cells migrated faster and showed greater glucose uptake and increased expression of GLUTs.

  10. Findings suggest a novel role for Hfe and/or imbalanced iron homeostasis in the regulation of the inflammatory response in the lung and hereditary hemochromatosis.

HFE Protein Profile

Protein Summary

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.

Alternative names and synonyms associated with HFE

  • hemochromatosis (HFE)
  • hemochromatosis (Hfe)
  • HFE1 protein
  • HH protein
  • HLA-H protein
  • MR2 protein
  • MVCD7 protein
  • TFQTL2 protein

Protein level used designations for Hemochromatosis Proteins (HFE)

MHC class I-like protein HFE , hereditary hemochromatosis protein , hereditary hemochromatosis protein HLA-H , high Fe , RT1-CAFE , hereditary hemochromatosis protein homolog , hemochromatosis protein

3077 Homo sapiens
497622 Bos taurus
29199 Rattus norvegicus
15216 Mus musculus
462489 Pan troglodytes
100688951 Canis lupus familiaris
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