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Prion Protein ELISA Kits (PRNP)
On www.antibodies-online.com are 26 Prion Protein (PRNP) ELISA Kits from 8 different suppliers available. Additionally we are shipping PRNP Antibodies (210) and PRNP Proteins (54) and many more products for this protein. A total of 298 PRNP products are currently listed.
Synonyms:
AA960666, AI325101, AltPrP, ASCR, BIMP2, CARMA2, CD230, CJD, GSS, KURU, MGC84114, p27-30, prion, PRIP, Prn, Prn-i, Prn-p, PRNP, Prp, prp(c), prP27-30, prP33-35C, PrP, PrPC, PrPSc, PSORS2, PSS1, Sinc, SIP

More ELISA Kits for PRNP Interaction Partners

Xenopus laevis Prion Protein (PRNP) interaction partners

Horse (Equine) Prion Protein (PRNP) interaction partners

  1. Results describe a single amino acid exchange within the loop, D167S, between mouse and horse prion protein (PrP) which is unique to the PrP sequences of equine species.

Human Prion Protein (PRNP) interaction partners

  1. Copper(II) interaction with the Human Prion 103-112 fragment and its mutants has been studied with various techniques. The studied human prion fragment contains both histidine and methionine residues, while methionine residues are systematically replaced or displaced in the studied mutants

  2. these data indicate that the disruption of the PrP(C)-HOP (show STIP1 ELISA Kits) complex could be a potential therapeutic target for modulating the migratory and invasive cellular properties that lead to metastatic Colorectal cancer (CRC (show CALR ELISA Kits)).

  3. computational approach to elucidate in details the aggregation propensity of PrP (show C4BPA ELISA Kits) protein systems including wild type, wild type treated at different [Ca2 (show CA2 ELISA Kits)+] or E200K mutant; models for the self-assembly of either the E200K mutated or Ca2 (show CA2 ELISA Kits)+-bound PrPC were sketched and discussed

  4. MALT1 (show MALT1 ELISA Kits) deficiency or pharmacological inhibition of MALT1 (show MALT1 ELISA Kits) catalytic activity inhibits pathogenic mutant CARD14 (show CARD14 ELISA Kits)-induced cytokine and chemokine (show CCL1 ELISA Kits) expression in human primary keratinocytes.

  5. The results have unraveled a novel molecular pathway driven by interactions between prion protein (PrP) and Notch1 (show NOTCH1 ELISA Kits) in the progression of pancreatic ductal adenocarcinoma (PDAC), supporting a critical tumor-promoting role of Notch1 (show NOTCH1 ELISA Kits) in PrP (show C4BPA ELISA Kits)-expressing PDAC tumors.

  6. CARD14 (show CARD14 ELISA Kits)/MALT1 (show MALT1 ELISA Kits)-mediated signaling in keratinocytes has a role in psoriasis [review]

  7. The results indicate that the common CARD14 (show CARD14 ELISA Kits) p.Arg820Trp variant might have a significant effect on the response to anti-TNF (show TNF ELISA Kits) therapies among patients with psoriasis. In addition, rare CARD14 (show CARD14 ELISA Kits) missense variants could also predispose to a better response.

  8. The present findings unveil particular neuropathological and neuroinflammatory profiles in Fatal familial insomnia(FFI) and novel characteristics of natural prion protein in FFI, altered PrPres and Scrapie PrP (show C4BPA ELISA Kits) (abnormal and pathogenic PrP (show C4BPA ELISA Kits)) patterns and region-dependent putative capacity of PrP (show C4BPA ELISA Kits) seeding

  9. Our findings, combined with the published literature, suggest that Pityriasis Rubra Pilaris Type V, both familial and sporadic, can be caused by CARD14 (show CARD14 ELISA Kits) mutations.

  10. Distinctive properties of plaque-type dura mater (show NLRP5 ELISA Kits) graft-associated Creutzfeldt-Jakob disease PrPSc proteins in cell-protein misfolding cyclic amplification.

Cow (Bovine) Prion Protein (PRNP) interaction partners

  1. Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND (show PRND ELISA Kits)) Variation in Domestic Cattle

  2. Misfolded structures, with nonnative beta-strands formed in the flexible N-terminal domain of PRNP were found in acidic pH simulations.

  3. Genetic characterization of PRNP promoter indel variations and the polymorphism of open reading frames (ORFs) of PRNP and bovine prion-like Shadoo (SPRN (show SPRN ELISA Kits)) genes, are reported.

  4. data showed a differential timing of PrPC expression during early bovine development; the cell-specific expression of PrPC in bovine embryos was revealed to included the developing brain and spinal cord, peripheral nervous system, liver, and mesonephros

  5. The results indicate that certain negative feedback response elements are located in the 5' flanking region and intron1 of the PRNP gene, suggesting that regulation by transcription factors such as Sp1 (show SP1 ELISA Kits) and RP58 (show ZNF238 ELISA Kits) may contribute to the negative feedback mechanism of PRNP.

  6. allele and haplotype segregation at the polymorphic sites within the promoter (23indel) and intron 1 (12indel) regions of the PRNP

  7. PRNP gene variation in Pakistani cattle and buffaloes.

  8. A significant relation between the investigated PRNP indel polymorphisms (23 and 12 bp indels), and susceptibility of Polish Holstein-Friesian cattle to classical bovine spongiform encephalopathy, is reported.

  9. fibrils formed by the rabbit protein contain less beta-sheet structure and more alpha-helix structure than those formed by the proteins from human and cow

  10. these results identify a novel PrP(C)-interacting protein KCTD1 (show KCTD1 ELISA Kits) and suggest a new approach to investigating the unidentified physiological cellular function of PrP(C).

Mouse (Murine) Prion Protein (PRNP) interaction partners

  1. a simple purification strategy for single tryptophan, single cysteine-containing mutant variants of the mouse prion protein is presented, with yields comparable to that of the wild type protein.

  2. The study presented here further elucidates our understanding of the soluble oligomeric amyloid-beta-Abetao-binding cellular prion protein (PrP(C)) signaling pathway in a familial form of Alzheimer's disease (AD) by implicating PrP(C) as a potential therapeutic target for AD.

  3. The retention of prion protein in the endoplasmic reticulum prevents neuroblastoma (show ARHGEF16 ELISA Kits) cells from proteasome inhibition-induced cytotoxicity.

  4. Data, including data from studies using knockout/transgenic mice, suggest that PrPC is involved in development of insulin (show INS ELISA Kits) resistance and obesity; PrPC knockout mice fed high-fat diet present all the symptoms associated with insulin (show INS ELISA Kits) resistance (hyperglycemia, hyperinsulinemia, and obesity); transgenic mice overexpressing PrPC fed high-fat diet exhibit normal insulin (show INS ELISA Kits) sensitivity and reduced weight gain.

  5. PrP aggresomes are cytosolic overflow deposition centers for the endoplasmic reticulum quality control mechanisms.

  6. recombinant PrP functions as a signaling molecule, and its homophilic interaction with membrane-anchored PrP(C) might promote neurite outgrowth and facilitate growth cone guidance.

  7. Results suggest that prion protein PrPC combined with galectin-3 (show LGALS3 ELISA Kits) and -6 can act as a receptor for murine leukemia virus (MuLV).

  8. using a transgenic model we could not provide evidence to support the hypothesis that PrPC regulates amyloid-beta production

  9. PrP deficiency caused a loss or enhancement of NCAM1 (show NCAM1 ELISA Kits) polysialylation, dependent on the cell model used.

  10. ion channel formation may be a possible mechanism of PrP-mediated neurodegeneration by the transmembrane forms of PrP

Pig (Porcine) Prion Protein (PRNP) interaction partners

  1. single nucleotide polymorphisms (G11A, G615C, G684A, T726G) in the open reading frame of the porcine PRNP gene were found

Rabbit Prion Protein (PRNP) interaction partners

  1. fibrils formed by the rabbit protein contain less beta-sheet structure and more alpha-helix structure than those formed by the proteins from human and cow; strong inhibition of fibrillization of the rabbit PrP by the crowded physiological environment and the absence of such a protease-resistant fragment for the rabbit protein could be why rabbits are resistant to prion diseases

  2. Different overall sensitivities of prion protein toward urea denaturation occurs with stabilities in the following species order: hamster prion protein

  3. The comparison of the structural stability of prion proteins from the three species rabbit, human and mouse showed that the human and mouse prion protein structures were not affected by the removing the two salt bridges

  4. amyloid and oxidative stress-related disease proteins like prion protein are increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.

  5. The salt bridge between D177 and R163 greatly contributes to the structural stability of rabbit prion protein.

Rhesus Monkey Prion Protein (PRNP) interaction partners

  1. Data show the presence of PrP(Sc) in muscle and central nervous system of rhesus monkeys experimentally infected with vCJD.

  2. PrP(c) is expressed in all digestive regions of the rat, monkey, and cow; PrP(c) expressing cells appeared scattered throughout the epithelium of fundic and pyloric glands as well as in intestinal villi and crypts.

Golden Syrian Hamster Prion Protein (PRNP) interaction partners

  1. Findings indicate the molecular mechanisms of prion pathogenesis and strain diversity.

  2. Data indicate that prion protein PrP dimers were funneled into a thermodynamically stable misfolded state along a single pathway containing several intermediates.

  3. Here, we report that the degree of PrP(Sc) protease resistance is highly dependent on the concentration of salt in the solution.

  4. Localization of fully posttranslationally modified Syrian golden hamster glycosylated PrPC is confirmed in the plasma membrane together with the posttranslational glycosylation pattern.

PRNP Antigen Profile

Antigen Summary

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with PRNP

  • prion protein (prnp) Elisa Kit
  • prion protein (PRNP) Elisa Kit
  • caspase recruitment domain family, member 14 (CARD14) Elisa Kit
  • prion protein (Prnp) Elisa Kit
  • prion protein (PRP) Elisa Kit
  • AA960666 Elisa Kit
  • AI325101 Elisa Kit
  • AltPrP Elisa Kit
  • ASCR Elisa Kit
  • BIMP2 Elisa Kit
  • CARMA2 Elisa Kit
  • CD230 Elisa Kit
  • CJD Elisa Kit
  • GSS Elisa Kit
  • KURU Elisa Kit
  • MGC84114 Elisa Kit
  • p27-30 Elisa Kit
  • prion Elisa Kit
  • PRIP Elisa Kit
  • Prn Elisa Kit
  • Prn-i Elisa Kit
  • Prn-p Elisa Kit
  • PRNP Elisa Kit
  • Prp Elisa Kit
  • prp(c) Elisa Kit
  • prP27-30 Elisa Kit
  • prP33-35C Elisa Kit
  • PrP Elisa Kit
  • PrPC Elisa Kit
  • PrPSc Elisa Kit
  • PSORS2 Elisa Kit
  • PSS1 Elisa Kit
  • Sinc Elisa Kit
  • SIP Elisa Kit

Protein level used designations for Prion Protein (PRNP) ELISA Kits

prion protein , major prion protein , prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) , prion protein PrP , Major prion protein , CARD-containing MAGUK protein 2 , bcl10-interacting maguk protein 2 , card-maguk protein 2 , carma 2 , caspase recruitment domain-containing protein 14 , CD230 antigen , prion-related protein , major scrapie-associated fibril protein 1 , prion protein precursor PrP , prion protein variant a , prion protein variant b , prion protein, PrP , prion protein, structural , 65-21 protein , ARIA , PR-LP , acetylcholine receptor-inducing activity , major prion protein homolog , prion-like protein , prion-like-protein , prP27-30 , prP33-35C , glutathione synthetase , major prion protein preproprotein , prP , infectious amyloid , PrP 27-30

GENE ID SPECIES
444620 Xenopus laevis
554189 Monodelphis domestica
100065904 Equus caballus
100173712 Pongo abelii
100499575 Ailuropoda melanoleuca
79092 Homo sapiens
5621 Homo sapiens
281427 Bos taurus
493887 Ovis aries
19122 Mus musculus
24686 Rattus norvegicus
494014 Sus scrofa
493886 Felis catus
396452 Gallus gallus
485783 Canis lupus familiaris
100008658 Oryctolagus cuniculus
100345744 Oryctolagus cuniculus
717859 Macaca mulatta
458076 Pan troglodytes
101829062 Mesocricetus auratus
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