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Browse our PRNP (PRNP) ELISA Kits

Full name:
Prion Protein ELISA Kits (PRNP)
On www.antibodies-online.com are 22 Prion Protein (PRNP) ELISA Kits from 6 different suppliers available. Additionally we are shipping PRNP Antibodies (211) and PRNP Proteins (55) and many more products for this protein. A total of 296 PRNP products are currently listed.
Synonyms:
AA960666, AI325101, AltPrP, ASCR, BIMP2, CARMA2, CD230, CJD, GSS, KURU, MGC84114, p27-30, prion, PRIP, Prn, Prn-i, Prn-p, PRNP, Prp, prp(c), prP27-30, prP33-35C, PrP, PrPC, PrPSc, PSORS2, PSS1, Sinc, SIP

More ELISA Kits for PRNP Interaction Partners

Xenopus laevis Prion Protein (PRNP) interaction partners

Horse (Equine) Prion Protein (PRNP) interaction partners

  1. Results describe a single amino acid exchange within the loop, D167S, between mouse and horse prion protein (PrP) which is unique to the PrP sequences of equine species.

Human Prion Protein (PRNP) interaction partners

  1. The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein.

  2. genetic evidence suggests association of the CARD14 (show CARD14 ELISA Kits) single nucleotide polymorphism rs11652075 and other rare mutations in this gene with psoriasis. To assess whether combined data support the relationship between CARD14 (show CARD14 ELISA Kits) rs11652075 and susceptibility to this disease, we conducted a meta-analysis. Our results demonstrate a significant association between the CARD14 (show CARD14 ELISA Kits) rs11652075 polymorphism and psoriasis.

  3. This study demonstrated that Prion Protein-Hemin Interaction Upregulates Hemoglobin Synthesis.

  4. The authors observations provide further insights into the genetics of psoriasis and functional information on novel CARD14 (show CARD14 ELISA Kits) mutational variants seen in cases from Tunisia and other populations.

  5. Genetic interactions of SNPs in CARD14 (show CARD14 ELISA Kits), SENP1 (show SENP1 ELISA Kits) and VEGFA (show VEGFA ELISA Kits) might represent a functional mechanism in the pathogenesis of high altitude polycythemia.

  6. PrP (show C4BPA ELISA Kits)-Abeta (show APP ELISA Kits) oligomers binding might be the underlying mechanism of the prion diseases and Alzheimer's disease. [review]

  7. PrP(C) is highly enriched on exosomes from SH-SY5Y cells and that exosomes bind amyloid beta via PrP(C).

  8. The results suggest a role of PrP(C) in proteostasis, dysfunctions of which may be involved in the pathogenesis of neurodegenerative diseases such as TSE and Alzheimer's Disease.

  9. Effects such as the stabilization of the native alpha-fold, dictating the efficiency of the alpha-cleavage, attenuating the fibrillation propensity and yielding the most benign amyloids suggest that the charge design ensures PrPC functions.

  10. Genetic coupling between Prnp and glutamate receptor 5 is responsible for synapse loss in Alzheimer's disease transgenic mouse model.

Cow (Bovine) Prion Protein (PRNP) interaction partners

  1. Misfolded structures, with nonnative beta-strands formed in the flexible N-terminal domain of PRNP were found in acidic pH simulations.

  2. Genetic characterization of PRNP promoter indel variations and the polymorphism of open reading frames (ORFs) of PRNP and bovine prion-like Shadoo (SPRN (show SPRN ELISA Kits)) genes, are reported.

  3. data showed a differential timing of PrPC expression during early bovine development; the cell-specific expression of PrPC in bovine embryos was revealed to included the developing brain and spinal cord, peripheral nervous system, liver, and mesonephros

  4. The results indicate that certain negative feedback response elements are located in the 5' flanking region and intron1 of the PRNP gene, suggesting that regulation by transcription factors such as Sp1 (show SP1 ELISA Kits) and RP58 (show ZNF238 ELISA Kits) may contribute to the negative feedback mechanism of PRNP.

  5. allele and haplotype segregation at the polymorphic sites within the promoter (23indel) and intron 1 (12indel) regions of the PRNP

  6. PRNP gene variation in Pakistani cattle and buffaloes.

  7. A significant relation between the investigated PRNP indel polymorphisms (23 and 12 bp indels), and susceptibility of Polish Holstein-Friesian cattle to classical bovine spongiform encephalopathy, is reported.

  8. fibrils formed by the rabbit protein contain less beta-sheet structure and more alpha-helix structure than those formed by the proteins from human and cow

  9. these results identify a novel PrP(C)-interacting protein KCTD1 (show KCTD1 ELISA Kits) and suggest a new approach to investigating the unidentified physiological cellular function of PrP(C).

  10. Different overall sensitivities of prion protein toward urea denaturation occurs with stabilities in the following species order: hamster prion protein

Mouse (Murine) Prion Protein (PRNP) interaction partners

  1. present our observations made during systematic experiments with the CC9 system targeting the endogenous Prnp locus, to either modify sequences or to boost PrP expression using CC9-based synergistic activation mediators

  2. Though astrocytes are capable of secreting PrP, this is an inefficient method of transferring prion infectivity. Efficient transfer required co-culturing and direct cell contact. Astrocytes form numerous intercellular connections including tunneling nanotubes, containing PrP(Sc), often colocalized with endolysosomal vesicles, which may constitute the major mechanism of transfer.

  3. PrP(C) promotes myelin homeostasis through flexible tail-mediated Gpr126 (show GPR126 ELISA Kits) agonism

  4. Thus, we conclude that 'rigidity' in the b2-a2 loop region of the normal conformer of PrP has less effect on misfolding than other sequence-related effects in this region.

  5. The prion protein is required to form the splenic white pulp structure and for development of normal levels of CD4 (show CD4 ELISA Kits) and helper-inducer T cells.

  6. PrP(C) is highly enriched on exosomes from N2a cells. Exosomes bind amyloid beta via PrP(C).

  7. Data suggest that expression of shadoo (show SPRN ELISA Kits) in neuron or hepatocyte cell lines induces same toxic phenotype of drug hypersensitivity as prion protein/PrP(-central region); this effect is counteracted by co-expression of PrP-wild-type.

  8. aged Prnp(ZH3/ZH3) mice developed a chronic demyelinating peripheral neuropathy, confirming the crucial involvement of PrP(C) in peripheral myelin maintenance.

  9. Neuroprotective effect of cellular prion protein (PrPC) is related with activation of alpha7 nicotinic acetylcholine receptor (alpha7nAchR)-mediated autophagy flux.

  10. Kinetics of prp folding and unfolding shows an equilibrium A-state corresponding to a late folding intermediate, which is a monomeric precursor of aggregates suggesting the A-state is a branching point between the folding and aggregation pathways.

Pig (Porcine) Prion Protein (PRNP) interaction partners

  1. single nucleotide polymorphisms (G11A, G615C, G684A, T726G) in the open reading frame of the porcine PRNP gene were found

Rabbit Prion Protein (PRNP) interaction partners

  1. fibrils formed by the rabbit protein contain less beta-sheet structure and more alpha-helix structure than those formed by the proteins from human and cow; strong inhibition of fibrillization of the rabbit PrP by the crowded physiological environment and the absence of such a protease-resistant fragment for the rabbit protein could be why rabbits are resistant to prion diseases

  2. Different overall sensitivities of prion protein toward urea denaturation occurs with stabilities in the following species order: hamster prion protein

  3. The comparison of the structural stability of prion proteins from the three species rabbit, human and mouse showed that the human and mouse prion protein structures were not affected by the removing the two salt bridges

  4. amyloid and oxidative stress-related disease proteins like prion protein are increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.

  5. The salt bridge between D177 and R163 greatly contributes to the structural stability of rabbit prion protein.

Rhesus Monkey Prion Protein (PRNP) interaction partners

  1. Data show the presence of PrP(Sc) in muscle and central nervous system of rhesus monkeys experimentally infected with vCJD.

  2. PrP(c) is expressed in all digestive regions of the rat, monkey, and cow; PrP(c) expressing cells appeared scattered throughout the epithelium of fundic and pyloric glands as well as in intestinal villi and crypts.

Golden Syrian Hamster Prion Protein (PRNP) interaction partners

  1. Findings indicate the molecular mechanisms of prion pathogenesis and strain diversity.

  2. Data indicate that prion protein PrP dimers were funneled into a thermodynamically stable misfolded state along a single pathway containing several intermediates.

  3. Here, we report that the degree of PrP(Sc) protease resistance is highly dependent on the concentration of salt in the solution.

  4. Localization of fully posttranslationally modified Syrian golden hamster glycosylated PrPC is confirmed in the plasma membrane together with the posttranslational glycosylation pattern.

PRNP Antigen Profile

Antigen Summary

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with PRNP

  • prion protein (prnp) Elisa Kit
  • prion protein (PRNP) Elisa Kit
  • caspase recruitment domain family, member 14 (CARD14) Elisa Kit
  • prion protein (Prnp) Elisa Kit
  • prion protein (PRP) Elisa Kit
  • AA960666 Elisa Kit
  • AI325101 Elisa Kit
  • AltPrP Elisa Kit
  • ASCR Elisa Kit
  • BIMP2 Elisa Kit
  • CARMA2 Elisa Kit
  • CD230 Elisa Kit
  • CJD Elisa Kit
  • GSS Elisa Kit
  • KURU Elisa Kit
  • MGC84114 Elisa Kit
  • p27-30 Elisa Kit
  • prion Elisa Kit
  • PRIP Elisa Kit
  • Prn Elisa Kit
  • Prn-i Elisa Kit
  • Prn-p Elisa Kit
  • PRNP Elisa Kit
  • Prp Elisa Kit
  • prp(c) Elisa Kit
  • prP27-30 Elisa Kit
  • prP33-35C Elisa Kit
  • PrP Elisa Kit
  • PrPC Elisa Kit
  • PrPSc Elisa Kit
  • PSORS2 Elisa Kit
  • PSS1 Elisa Kit
  • Sinc Elisa Kit
  • SIP Elisa Kit

Protein level used designations for Prion Protein (PRNP) ELISA Kits

prion protein , major prion protein , prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) , prion protein PrP , Major prion protein , CARD-containing MAGUK protein 2 , bcl10-interacting maguk protein 2 , card-maguk protein 2 , carma 2 , caspase recruitment domain-containing protein 14 , CD230 antigen , prion-related protein , major scrapie-associated fibril protein 1 , prion protein precursor PrP , prion protein variant a , prion protein variant b , prion protein, PrP , prion protein, structural , 65-21 protein , ARIA , PR-LP , acetylcholine receptor-inducing activity , major prion protein homolog , prion-like protein , prion-like-protein , prP27-30 , prP33-35C , glutathione synthetase , major prion protein preproprotein , prP , infectious amyloid , PrP 27-30

GENE ID SPECIES
444620 Xenopus laevis
554189 Monodelphis domestica
100065904 Equus caballus
100173712 Pongo abelii
100499575 Ailuropoda melanoleuca
79092 Homo sapiens
5621 Homo sapiens
281427 Bos taurus
493887 Ovis aries
19122 Mus musculus
24686 Rattus norvegicus
494014 Sus scrofa
493886 Felis catus
396452 Gallus gallus
485783 Canis lupus familiaris
100008658 Oryctolagus cuniculus
100345744 Oryctolagus cuniculus
717859 Macaca mulatta
458076 Pan troglodytes
101829062 Mesocricetus auratus
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