PRNP Products
(Prion Protein (PRNP))
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The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].
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Featured PRNP Categories
PRNP Antibodies
High quality antibodies with extensive validation data.
PRNP ELISA Kits
Reliable ELISA kits for a wide range of species.
PRNP Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PRNP Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7433921
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (4)
Cat. No.
ABIN7193415
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN7260569
Quantity
200 μL
Datasheet
Datasheet
Recommended PRNP ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969500
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969499
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958725
Quantity
96 tests
Datasheet
Datasheet
Recommended PRNP Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275480
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7275481
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316351
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PRNP products
: "Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 4, pp. 5082-5088, (2020) (PubMed).: "Effects of cellular prion protein on rapid eye movement sleep deprivation-induced spatial memory impairment." in: Journal of integrative neuroscience, Vol. 18, Issue 4, pp. 439-444, (2020) (PubMed).
: "Atypical scrapie in Australia." in: Australian veterinary journal, Vol. 94, Issue 12, pp. 452-455, (2016) (PubMed).
: "Geno- and phenotyping of human neutrophil antigens." in: Methods in molecular biology (Clifton, N.J.), Vol. 1310, pp. 193-203, (2016) (PubMed).
: "Allelic variants at codon 146 in the PRNP gene show significant differences in the risk for natural scrapie in Cypriot goats." in: Epidemiology and infection, Vol. 143, Issue 6, pp. 1304-10, (2015) (PubMed).
: "Polo-like kinase 3 (PLK3) mediates the clearance of the accumulated PrP mutants transiently expressed in cultured cells and pathogenic PrP(Sc) in prion infected cell line via protein interaction." in: The international journal of biochemistry & cell biology, Vol. 62, pp. 24-35, (2015) (PubMed).
: "Identification of a Compound That Disrupts Binding of Amyloid-β to the Prion Protein Using a Novel Fluorescence-based Assay." in: The Journal of biological chemistry, Vol. 290, Issue 27, pp. 17020-8, (2015) (PubMed).
: "The prion protein inhibits monocytic cell migration by stimulating β1 integrin adhesion and uropod formation." in: Journal of cell science, Vol. 128, Issue 16, pp. 3018-29, (2015) (PubMed).
: "Detection of the GPI-anchorless prion protein fragment PrP226* in human brain." in: BMC neurology, Vol. 13, pp. 126, (2013) (PubMed).
: "The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6." in: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37241-55, (2013) (PubMed).
Synonyms and alternative names related to PRNP
prion protein (PRNP), prion protein (Prnp), prion protein S homeolog (prnp.S), prion protein b (prnpb), AA960666, AI325101, AltPrP, ASCR, CD230, CJD, cjd, GSS, KURU, MGC84114, p27-30, prion, PRIP, Prn, Prn-i, Prn-p, PRNP, prnprs1, PrP, prp, PRP, Prp, prp(c), PrP-1, PrP1, PrP27-30, prP27-30, PrP33-35C, prP33-35C, PrPProtein level used designations for PRNP
- CD230 antigen
- major prion protein
- prion-related protein
- prion protein, PrP
- prion protein, structural
- major scrapie-associated fibril protein 1
- prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)
- prion protein PrP
- prion protein precursor PrP
- prion protein variant a
- prion protein variant b
- 65-21 protein
- ARIA
- PR-LP
- acetylcholine receptor-inducing activity
- major prion protein homolog
- prion-like protein
- prion-like-protein
- prion protein
- infectious amyloid
- Major prion protein
- major prion protein preproprotein
- prP
- prP27-30
- prP33-35C
- PrP 27-30
- prion protein 1
- prion protein b
- prion protein, related sequence 1
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