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anti-Human DVL2 Antibodies:
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Our findings reveal an underappreciated role of Dvl2 in regulating inflammation and rheumatoid arthritis-fibroblast-like synoviocyte apoptosis
two mutually exclusive functions of the DEP (show ZDHHC21 Antibodies) domain in Wnt (show WNT2 Antibodies) signal transduction - binding to Frizzled to recruit Dishevelled to the receptor complex, is reported.
inhibition of DVL2 can sensitize cisplatin-resistant lung cancer cells through down-regulating Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
Data show that RAP1B (show RAP1B Antibodies) expression was up-regulated in esophageal squamous cell carcinoma (ESCC) clinical samples and RAP1B (show RAP1B Antibodies) interacted with DVL2 and activated Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
ESCC patients with high Dvl2 expression had worse prognoses and multivariate analysis indicated that Dvl2 was an independent risk factor for ESCC patients' survival. Our clinical data indicated that Dvl2 contribute to the malignant progression of ESCC and might be a prognostic biomarker.
Data show that dishevelled proteins DVL1 (show DVL1 Antibodies), 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
The secreted frizzled-related protein (show SFRP2 Antibodies) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.
In pancreatic cancer cells, AF6 (show MLLT4 Antibodies) is expressed at reduced levels, causing Dvl2 to be upregulated and available to bind and enhance FOXE1 (show FOXE1 Antibodies)-induced trans-activation of Snail (show SNAI1 Antibodies), which promotes proliferation and metastasis.
Epsins are required for Dishevelled stability and Wnt (show WNT2 Antibodies) signalling activation in colon cancer development.
The data suggest that the expression of DVL2 in colon tissue segments may be important in the pathogenesis of HSCR (show EDNRB Antibodies).
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
dishevelled 2 (homologous to Drosophila dsh)
, dishevelled, dsh homolog 2
, segment polarity protein dishevelled homolog DVL-2