Browse our EDAR Proteins (EDAR)

Full name:
Ectodysplasin A Receptor Proteins (EDAR)
On are 19 Ectodysplasin A Receptor (EDAR) Proteins from 5 different suppliers available. Additionally we are shipping EDAR Antibodies (73) and EDAR Kits (3) and many more products for this protein. A total of 102 EDAR products are currently listed.
dl, ECTD10A, ECTD10B, ED1R, ED3, ED5, EDA-A1R, EDA1R, EDA3, EDAR, HRM1, MGC88893, RGD1561714, rs3
list all proteins Gene Name GeneID UniProt
EDAR 10913 Q9UNE0
EDAR 13608 Q9R187
EDAR 365581  

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EDAR Proteins (EDAR) by Origin

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Top referenced EDAR Proteins

  1. Human EDAR Protein expressed in Human Cells - ABIN2004387 : Fessing, Sharova, Sharov, Atoyan, Botchkarev: Involvement of the Edar signaling in the control of hair follicle involution (catagen). in The American journal of pathology 2006 (PubMed)
    Show all 3 references for 2004387

  2. Cynomolgus EDAR Protein expressed in Human Cells - ABIN2009872 : Drew, Lin, Jiang, Blunt, Mou, Chuong, Headon: The Edar subfamily in feather placode formation. in Developmental biology 2007 (PubMed)
    Show all 3 references for 2009872

  3. Rat (Rattus) EDAR Protein expressed in Human Cells - ABIN2009342 : Fujimoto, Kimura, Ohashi, Omi, Yuliwulandari, Batubara, Mustofa, Samakkarn, Settheetham-Ishida, Ishida, Morishita, Furusawa, Nakazawa, Ohtsuka, Tokunaga: A scan for genetic determinants of human hair morphology: EDAR is associated with Asian hair thickness. in Human molecular genetics 2008 (PubMed)
    Show all 3 references for 2009342

More Proteins for EDAR Interaction Partners

Medaka Ectodysplasin A Receptor (EDAR) interaction partners

  1. These data suggest differential roles for Eda (show EDA Proteins)-Edar signaling in the induction and growth of scales and teeth and support the intrinsic odontogenic competence of the rostral endoderm in medaka.

Zebrafish Ectodysplasin A Receptor (EDAR) interaction partners

  1. Eda (show EDA Proteins) and edar are not required for early development but are specific for the development of adult skeletal and dental structures.

Human Ectodysplasin A Receptor (EDAR) interaction partners

  1. To evaluate the relative contribution of these variants, we performed a second genome-wide scan in 709 samples from the Uyghur, an admixed population with both eastern and western Eurasian ancestries. In Uyghurs, both EDAR (rs3827760: P = 1.92 x 10(-12)) and TCHH (rs11803731: P = 1.46 x 10(-3)) are associated with hair straightness, but EDAR (OR 0.415) has a greater effect than TCHH (OR 0.575).

  2. Four traits of ear pinna anatomic variation are associated with a functional variant in the EDAR gene, a key regulator of embryonic skin appendage development.

  3. Individuals with a c.1072C > T mutation in the EDAR-gene displayed more hair shaft deformations confirming the role of EDAR for human hair follicle development and postnatal hair follicle cycling.

  4. Individuals with a c.1072C > T mutation in the EDAR-gene displayed a typical pattern of congenitally missing teeth in the frontal area with functional consequences.

  5. Using whole-exome sequencing we describe a novel homozygous missense mutation in EDAR causing autosomal recessive HED (show EDA Proteins) associated with palmoplantar hyperkeratosis and the absence of breasts.

  6. Study generated a knockin mouse model and found that, as in humans, hair thickness is increased in EDAR370A mice; new biological targets affected by the mutation were identified, including mammary and eccrine glands. Building on these results EDAR370A was found to be associated with an increased number of active eccrine glands in the Han Chinese.

  7. This is the first report of a founder EDAR mutation and of a significantly high frequency of autosomal recessive HED (show EDA Proteins).

  8. WNT10A (show WNT10A Proteins) and EDAR were each responsible for 16% of hypohidrotic/anhidrotic ectodermal dysplasia cases.

  9. screening of all the 12 exons and splice junctions of gene EDAR revealed a novel missense mutation (c.1163T>C; p.Ile388Thr) in family A and a novel insertion mutation (c.1014insA; p.V339SfsX6) in family B.

  10. Data show that 25 different mutations on EDA (show EDA Proteins) and EDAR genes were detected in HED (show EDA Proteins) patients.

Mouse (Murine) Ectodysplasin A Receptor (EDAR) interaction partners

  1. Mouse models with HED (show EDA Proteins) also carry Eda (show EDA Proteins), Edar or Edaradd (show EDARADD Proteins) mutations and have defects that map to the same structures.We report that otitis media, rhinitis and nasopharyngitis occur at high frequency in Eda (show EDA Proteins) and Edar mutant mice and explore the pathogenic mechanisms related to glandular function, microbial and immune parameters in these lines

  2. Edar is expressed in the developing ear. Edar-deficient mice have an abnormally shaped pinna.

  3. Edar signalling has pleiotropic effects on craniofacial and cutaneous glands

  4. Edar expression is confined to the ectoderm and occurs in a pattern that suggests a role of ectodysplasin/Edar signaling in the interactions between the ectodermal compartments and the formation and function of hair placodes.

  5. Analysis of expression patterns of eda (show EDA Proteins), edar and tnfrsf19 (show TNFRSF19 Proteins) in mouse embryogenesis.

  6. Data show that Edar misexpression disrupts tooth patterning and differentiation.

  7. isoforms of EDA (show EDA Proteins)-A5 and A5',activated NF-kappaB (show NFKB1 Proteins) through receptors EDAR and XEDAR (show EDA2R Proteins)

  8. demonstrate that epidermal NF-kappaB (show NFKB1 Proteins) activity is first observed in placodes of primary guard hair follicles at day E14.5, and that in vivo NF-kappaB (show NFKB1 Proteins) signalling is activated downstream of Eda A1 (show EDA Proteins) and EdaR

  9. Data show that ectodysplasin receptor (Edar)-bone morphogenetic protein (BMP)-4 and -7 signaling and transcriptional interactions are central to generation of the primary hair follicle pattern.

  10. Thus, our data demonstrate that in addition to its well-established role in HF morphogenesis, Edar signaling is also involved in hair cycle control and regulates apoptosis in HF keratinocytes during catagen.

EDAR Protein Profile

Protein Summary

This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.

Alternative names and synonyms associated with EDAR

  • ectodysplasin-A receptor (edar)
  • ectodysplasin receptor (edar)
  • ectodysplasin A receptor (edar)
  • ectodysplasin A receptor (EDAR)
  • ectodysplasin-A receptor (Edar)
  • dl protein
  • ECTD10A protein
  • ECTD10B protein
  • ED1R protein
  • ED3 protein
  • ED5 protein
  • EDA-A1R protein
  • EDA1R protein
  • EDA3 protein
  • EDAR protein
  • HRM1 protein
  • MGC88893 protein
  • RGD1561714 protein
  • rs3 protein

Protein level used designations for EDAR

RS-3 , protein reduced scale-3 , tumor necrosis factor receptor superfamily member EDAR , ectodysplasin receptor , finless , fls , ectodysplasin A receptor , tumor necrosis factor receptor superfamily member EDAR-like , EDA-A1 receptor , anhidrotic ectodysplasin receptor 1 , downless homolog , downless, mouse, homolog of , ectodermal dysplasia receptor , ectodysplasin 1, anhidrotic receptor , ectodysplasin-A receptor , ectodysplasin A1 receptor , downless

100049352 Oryzias latipes
100174891 Gasterosteus aculeatus
796370 Danio rerio
735810 Pan troglodytes
448544 Xenopus (Silurana) tropicalis
100060614 Equus caballus
695059 Macaca mulatta
100387176 Callithrix jacchus
100432950 Pongo abelii
10913 Homo sapiens
428015 Gallus gallus
481305 Canis lupus familiaris
613947 Bos taurus
13608 Mus musculus
365581 Rattus norvegicus
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