Browse our IRX3 Proteins (IRX3)

Full name:
Iroquois Homeobox 3 Proteins (IRX3)
On are 5 Iroquois Homeobox 3 (IRX3) Proteins from 3 different suppliers available. Additionally we are shipping IRX3 Antibodies (92) and many more products for this protein. A total of 107 IRX3 products are currently listed.
AI894186, iro3, IRX-1, irx3b, IRXB1, xiro-3, xiro3
list all proteins Gene Name GeneID UniProt
Rat IRX3 IRX3 307721  
IRX3 79191 P78415
IRX3 16373 P81067

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IRX3 Proteins (IRX3) by Origin

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More Proteins for IRX3 Interaction Partners

Human Iroquois Homeobox 3 (IRX3) interaction partners

  1. Increased adipocyte-specific expression of IRX3 correlates with the presence of the FTO obesity risk haplotype in lean children, whereas it was unaffected by risk variants in obese peers. IRX3 expression in adipocytes was significantly related to adipocyte hypertrophy.

  2. the association between FTO and obesity appears to be due to its influence on expression of IRX3 [Figure 1]. Genetic studies indicated FTO as an important gene for obesity risk in various populations but the recent developments suggest that obesity-associated FTO SNPs have long-range interactions with IRX3.

  3. Downregulation of miR (show MLXIP Proteins)-377 may contribute to the upregulation of IRX3 in HCC (show FAM126A Proteins).

  4. This is the first study to reveal that genetic variants of both FTO and IRX3 genes are in high linkage disequilibrium (LD) and are associated with obesity risk in North Indians.

  5. Strategies to pharmacologically regulate Irx3 function in adult endothelial cells may provide new therapies for angiogenesis.

  6. data suggest that IRX3 is a functional long-range target of obesity-associated variants within FTO (show FTO Proteins) and represents a novel determinant of body mass and composition

  7. IRX3 function may have a direct functional relationship to both obesity and type 2 diabetes.

Xenopus laevis Iroquois Homeobox 3 (IRX3) interaction partners

  1. barH-like homeobox-2 (show BARHL2 Proteins) gene barhl2 (show BARHL2 Proteins) acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog (show SHH Proteins)

  2. Irx3 is transcriptionally induced by the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway during anteroposterior patterning of the neural axis.

  3. Irx3 is the first gene known to be necessary and sufficient to specify nephron segment fate in vivo.

Mouse (Murine) Iroquois Homeobox 3 (IRX3) interaction partners

  1. Irx3 is necessary for the postnatal maturation of the VCS (show EDC4 Proteins), possibly via its interactions with Tbx5 (show TBX5 Proteins) and Nkx2.5 (show NKX2-5 Proteins).

  2. Irx3 and Irx5 (Irx3/5) are essential in the initiating limb bud to specify progenitors of the femur, tibia, and digit 1.

  3. data suggest that IRX3 is a functional long-range target of obesity-associated variants within FTO (show FTO Proteins) and represents a novel determinant of body mass and composition

  4. postnatal Irx3 activity can be repressed by Irx5 (show IRX5 Proteins)

  5. Irx3 is critical for efficient conduction in this specialized tissue by antithetically regulating two gap junction-forming connexins

  6. Irx3 signal is restricted to the somatic cell component of XX gonads and is present at a discreet period of ovarian development that ends at birth.

IRX3 Protein Profile

Protein Summary

IRX3 is a member of the Iroquois homeobox gene family (see IRX1\; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998

Alternative names and synonyms associated with IRX3

  • iroquois homeobox 3 (IRX3)
  • iroquois homeobox 3 (Irx3)
  • iroquois homeobox 3 (irx3)
  • Iroquois related homeobox 3 (Drosophila) (Irx3)
  • AI894186 protein
  • iro3 protein
  • IRX-1 protein
  • irx3b protein
  • IRXB1 protein
  • xiro-3 protein
  • xiro3 protein

Protein level used designations for Iroquois Homeobox 3 Proteins (IRX3)

iroquois homeobox protein 3 , iroquois-class homeodomain protein IRX-3 , Iroquois related homeobox 3 , homeodomain protein IRXB1 , iroquois-class homeodomain protein IRX-1 , Iroquois homeobox protein 3 , homeobox transcription factor iroquois 3 , iroquois type homeobox , iroquois-class homeodomain protein irx-3

487277 Canis lupus familiaris
540417 Bos taurus
307721 Rattus norvegicus
79191 Homo sapiens
399365 Xenopus laevis
16373 Mus musculus
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