Browse our anti-SETD2 (SETD2) Antibodies

Full name:
anti-SET Domain Containing 2 Antibodies (SETD2)
On are 75 SET Domain Containing 2 (SETD2) Antibodies from 14 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 80 SETD2 products are currently listed.
HBP231, HIF-1, HIP-1, HYPB, Kif9, KMT3A, p231HBP, SET2
list all antibodies Gene Name GeneID UniProt
SETD2 316013  
SETD2 29072 Q9BYW2

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anti-Rat (Rattus) SETD2 Antibodies:

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anti-Mouse (Murine) SETD2 Antibodies:

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Top referenced anti-SETD2 Antibodies

  1. Cow (Bovine) Polyclonal SETD2 Primary Antibody for IHC, WB - ABIN2783051 : Barrand, Andersen, Collas: Promoter-exon relationship of H3 lysine 9, 27, 36 and 79 methylation on pluripotency-associated genes. in Biochemical and biophysical research communications 2010 (PubMed)

  2. Mouse (Murine) Polyclonal SETD2 Primary Antibody for ELISA, WB - ABIN262286 : Sun, Wei, Wu, Hu, Wang, Wang, Zhang, Chen, Huang, Chen: Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. in The Journal of biological chemistry 2005 (PubMed)

  3. Human Polyclonal SETD2 Primary Antibody for ICC, IF - ABIN4320758 : Kanu, Grönroos, Martinez, Burrell, Yi Goh, Bartkova, Maya-Mendoza, Mistrík, Rowan, Patel, Rabinowitz, East, Wilson, Santos, McGranahan, Gulati, Gerlinger, Birkbak, Joshi, Alexandrov, Stratton, Powles et al.: SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair. ... in Oncogene 2015 (PubMed)

More Antibodies against SETD2 Interaction Partners

Human SET Domain Containing 2 (SETD2) interaction partners

  1. SETD2 aberration as a recurrent, early loss-of-function event in CLL pathobiology linked to aggressive disease

  2. Setd2 as a potent tumor suppressor in lung adenocarcinoma.

  3. This study reports a new role for SETD2 in promoting IFNalpha-induced antiviral immune response by directly methylating STAT1 (show STAT1 Antibodies) on lysine 525 and catalyzing H3K36me3 on the promoters of some IFN-stimulated genes (ISGs such as ISG15 (show ISG15 Antibodies)) to activate gene transcription. Thus, SETD2 enhances host antiviral immunity by strengthening IFNalpha signaling both post-translationally and epigenetically.

  4. SETD2 is a novel GIST tumour suppressor gene associated with disease progression.

  5. Results identified new role for SETD2 in the methylation of K40 of alpha-tubulin (show TUBA4A Antibodies). Loss of SETD2 abolishes methylation of K40 of alpha-tubulin (show TUBA4A Antibodies) and results in a dysfunctional mitotic spindle and abnormalities in cytokinesis. Thus, SETD2 links chromatin and cytoskeleton homeostasis through its methyltransferase activity.

  6. Data suggest post-translational modifications of histones, trimethylation of lysine 36 in H3 (H3K36me3) and acetylation of lysine 16 in H4 (H4K16ac), have roles in DNA damage repair; H3K36me3 stimulates H4K16ac upon DNA double-strand break; SETD2, LEDGF (show PSIP1 Antibodies), and KAT5 (show KAT5 Antibodies) are required for these epigenetic changes. (SETD2 = SET domain containing 2; LEDGF (show PSIP1 Antibodies) = lens epithelium-derived growth factor (show PSIP1 Antibodies); KAT5 (show KAT5 Antibodies) = lysine acetyltransferase 5 (show KAT5 Antibodies))

  7. SETD2 gene deletion is associated with chordoma.

  8. SPOP (show SPOP Antibodies)-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing.

  9. one of these mutations (R2510H), located in the Set2 Rpb1 (show POLR2A Antibodies) interaction domain, did not result in an observable defect in SETD2 enzymatic function, a second mutation in the catalytic domain of this enzyme (R1625C) resulted in a complete loss of histone H3 (show HIST3H3 Antibodies) Lys (show LYZ Antibodies)-36 trimethylation (H3K36me3).

  10. functional loss of SETD2 enables renal primary tubular epithelial cells to bypass the senescence barrier by maintaining CDKN2A (show CDKN2A Antibodies)-E2F (show E2F1 Antibodies) signaling, facilitating a malignant transformation toward Clear Cell Renal Cell Carcinoma (show MOK Antibodies).

SETD2 Antigen Profile

Antigen Summary

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.

Alternative names and synonyms associated with SETD2

  • SET domain containing 2 (Setd2) antibody
  • SET domain containing 2 (SETD2) antibody
  • HBP231 antibody
  • HIF-1 antibody
  • HIP-1 antibody
  • HYPB antibody
  • Kif9 antibody
  • KMT3A antibody
  • p231HBP antibody
  • SET2 antibody

Protein level used designations for SETD2

histone-lysine N-methyltransferase SETD2 , kinesin family member 9 , huntingtin interacting protein 1 , huntingtin yeast partner B , huntingtin-interacting protein B , lysine N-methyltransferase 3A

316013 Rattus norvegicus
476643 Canis lupus familiaris
29072 Homo sapiens
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