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anti-Rat (Rattus) SETD2 Antibodies:
anti-Human SETD2 Antibodies:
anti-Mouse (Murine) SETD2 Antibodies:
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Cow (Bovine) Polyclonal SETD2 Primary Antibody for IHC, WB - ABIN2783051
Barrand, Andersen, Collas: Promoter-exon relationship of H3 lysine 9, 27, 36 and 79 methylation on pluripotency-associated genes. in Biochemical and biophysical research communications 2010
Mouse (Murine) Polyclonal SETD2 Primary Antibody for ELISA, WB - ABIN262286
Sun, Wei, Wu, Hu, Wang, Wang, Zhang, Chen, Huang, Chen: Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. in The Journal of biological chemistry 2005
Human Polyclonal SETD2 Primary Antibody for ICC, IF - ABIN4320758
Kanu, Grönroos, Martinez, Burrell, Yi Goh, Bartkova, Maya-Mendoza, Mistrík, Rowan, Patel, Rabinowitz, East, Wilson, Santos, McGranahan, Gulati, Gerlinger, Birkbak, Joshi, Alexandrov, Stratton, Powles et al.: SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair. ... in Oncogene 2015
SETD2 Mutation is associated with Clear Cell Renal Cell Carcinomas.
SETD2 downregulation affects the alternative splicing of a subset of genes implicated in intestinal tumorigenesis
SETD2 aberration as a recurrent, early loss-of-function event in CLL pathobiology linked to aggressive disease
Setd2 as a potent tumor suppressor in lung adenocarcinoma.
This study reports a new role for SETD2 in promoting IFNalpha-induced antiviral immune response by directly methylating STAT1 (show STAT1 Antibodies) on lysine 525 and catalyzing H3K36me3 on the promoters of some IFN-stimulated genes (ISGs such as ISG15 (show ISG15 Antibodies)) to activate gene transcription. Thus, SETD2 enhances host antiviral immunity by strengthening IFNalpha signaling both post-translationally and epigenetically.
SETD2 is a novel GIST tumour suppressor gene associated with disease progression.
Results identified new role for SETD2 in the methylation of K40 of alpha-tubulin (show TUBA4A Antibodies). Loss of SETD2 abolishes methylation of K40 of alpha-tubulin (show TUBA4A Antibodies) and results in a dysfunctional mitotic spindle and abnormalities in cytokinesis. Thus, SETD2 links chromatin and cytoskeleton homeostasis through its methyltransferase activity.
Data suggest post-translational modifications of histones, trimethylation of lysine 36 in H3 (H3K36me3) and acetylation of lysine 16 in H4 (H4K16ac), have roles in DNA damage repair; H3K36me3 stimulates H4K16ac upon DNA double-strand break; SETD2, LEDGF (show PSIP1 Antibodies), and KAT5 (show KAT5 Antibodies) are required for these epigenetic changes. (SETD2 = SET domain containing 2; LEDGF (show PSIP1 Antibodies) = lens epithelium-derived growth factor (show PSIP1 Antibodies); KAT5 (show KAT5 Antibodies) = lysine acetyltransferase 5 (show KAT5 Antibodies))
SETD2 gene deletion is associated with chordoma.
SPOP (show SPOP Antibodies)-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing.
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.
histone-lysine N-methyltransferase SETD2
, kinesin family member 9
, huntingtin interacting protein 1
, huntingtin yeast partner B
, huntingtin-interacting protein B
, lysine N-methyltransferase 3A