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Browse our Adenomatous Polyposis Coli Proteins (APC)

Full name:
Adenomatous Polyposis Coli Proteins (APC)
On www.antibodies-online.com are 4 Adenomatous Polyposis Coli (APC) Proteins from 2 different suppliers available. Additionally we are shipping Adenomatous Polyposis Coli Antibodies (200) and Adenomatous Polyposis Coli Kits (18) and many more products for this protein. A total of 237 Adenomatous Polyposis Coli products are currently listed.
Synonyms:
AI047805, APC1, AU020952, AW124434, BTPS2, CC1, DP2, DP2.5, DP3, fap, fpc, GS, mAPC, Min, PPP1R46, RATAPC, xapc
list all proteins Gene Name GeneID UniProt
APC 11789  
APC 324 P25054
APC 24205 P70478

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Adenomatous Polyposis Coli Proteins (APC) by Origin

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Mouse (Murine) Adenomatous Polyposis Coli (APC) interaction partners

  1. APC haploinsufficiency coupled with p53 (show TP53 Proteins) deletion resulted in the development of a distinct type of pancreatic premalignant precursors, mucinous cystic neoplasms (MCNs)

  2. Gasdermin C is upregulated by inactivation of Tgfbr2 (show TGFBR2 Proteins) in the presence of mutated Apc, promoting colorectal cancer cell proliferation.

  3. By sequencing Apc and Ctnnb1 (show CTNNB1 Proteins) genes, we found that most PhIP (show PHIP Proteins)-induced small intestinal tumors in obese mice carried only a single heterozygous mutation in Apc . Our findings demonstrate that PhIP (show PHIP Proteins)-induced small intestinal carcinogenesis in hCYP1A-db/db (show LEPR Proteins) mice is promoted by obesity and involves Apc mutation and inactivation by DNA hypermethylation

  4. Elevated coexpression of KITENIN and ErbB4 (show ERBB4 Proteins)-CYT (show CYGB Proteins)-2 promotes the transition of colon adenoma to adenocarcinoma within an APC loss-associated tumor microenvironment

  5. The activation of canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling by deletion of Apc in cardiomyocytes led to ventricular hyperplasia.

  6. demonstrated that despite having both Kras and Pik3ca (show PIK3CA Proteins) mutations at the time of tumor initiation from loss of APC

  7. Suggest that the early activation of Hsf1 (show HSF1 Proteins) dependent cell stress pathway by mono-allelic mutations in APC can affect cell programming in a way that contributes to cancer onset.

  8. Adenomatous polyposis coli mutation leads to myopia development in mice.

  9. findings indicate Ctnnb1 (show CTNNB1 Proteins) gene dose exerts tissue-specific differences in Apc mutation-instigated tumorigenesis

  10. Microsatellite instability in the Apc gene does not significantly affect chlorinated water-induced colonic tumorigenesis.

Human Adenomatous Polyposis Coli (APC) interaction partners

  1. Gasdermin C is upregulated by inactivation of Tgfbr2 (show TGFBR2 Proteins) in the presence of mutated Apc, promoting colorectal cancer cell proliferation.

  2. Nine patients with 21- approximately 100 colorectal adenomas (50%) and the two positive controls, showed somatic mosaicism, with identical APC variants in adenomas tested.

  3. These result suggested that miR (show MLXIP Proteins)-590-3p can promote osteogenic differentiation via suppressing APC expression and stabilizing beta-catenin (show CTNNB1 Proteins).

  4. The present findings indicate epigenetic silencing of APC in advanced gallbladder cancer (GBC). The methylation pattern, followed by expression analysis of APC may be suggested for diagnostic, prognostic and therapeutic purposes in GBC in future

  5. miR (show MLXIP Proteins)-106a-5p is involved in the invasive behavior of glioblastoma cells and by targeting APC and activating Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.

  6. Point Mutations in Exon 1B of APC Reveal Similar mutations in APC promoter 1B occur in rare families with familial adenomatous polyposis

  7. Studies suggest that both loss of tumor suppressive function and gain of function of APC mutants play critical roles in colorectal cancers (CRC (show CALR Proteins)) tumorigenesis.

  8. Loss of heterozygosity of TP53 (show TP53 Proteins), P16, SMAD4 (show SMAD4 Proteins) and APC genes was observed in esophageal adenocarcinoma.

  9. miR (show MLXIP Proteins)-582-5P was upregulated in the colorectal cancer specimens and cell lines and targeted the 3' untranslated region of APC directly.

  10. Loss of APC expression through methylation of its promoter is a widespread phenomenon in Wnt (show WNT2 Proteins)//beta-catenin (show CTNNB1 Proteins) activated tumors.

Xenopus laevis Adenomatous Polyposis Coli (APC) interaction partners

  1. the Amer2 (show AMER2 Proteins)-EB1 (show MAPRE1 Proteins)-APC complex regulates cell migration by altering microtubule stability.

  2. Data show that importin-beta (show KPNB1 Proteins) binds to Apc and negatively regulates the MT-assembly and spindle-promoting activity of Apc in a Ran-regulatable manner.

  3. APC and Axin (show AXIN1 Proteins) are involved in the Wnt (show WNT2 Proteins) pathway

  4. depletion of APC from cystostatic factor (CSF (show CSF2 Proteins)) Xenopus extracts leads to a decrease in microtubule density and changes in tubulin (show TUBB Proteins) distribution in spindles and asters formed in such extracts

  5. An interaction of tumor-associated N-terminal APC fragments (N-APC) with Mad2 (show MAD2L1 Proteins), an essential mitotic checkpoint (show BUB3 Proteins) protein, providing a direct molecular support for linking APC mutations to the generation of chromosome instability, is reported.

Adenomatous Polyposis Coli (APC) Protein Profile

Protein Summary

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Alternative names and synonyms associated with Adenomatous Polyposis Coli (APC)

  • adenomatous polyposis coli (APC)
  • adenomatous polyposis coli (apc)
  • adenomatous polyposis coli protein (Smp_139190)
  • adenomatosis polyposis coli (Apc)
  • adenomatous polyposis coli (Apc)
  • AI047805 protein
  • APC1 protein
  • AU020952 protein
  • AW124434 protein
  • BTPS2 protein
  • CC1 protein
  • DP2 protein
  • DP2.5 protein
  • DP3 protein
  • fap protein
  • fpc protein
  • GS protein
  • mAPC protein
  • Min protein
  • PPP1R46 protein
  • RATAPC protein
  • xapc protein

Protein level used designations for APC

adenomatosis polyposis coli , adenomatous polyposis coli protein , multiple intestinal neoplasia , adenomatosis polyposis coli tumor suppressor , deleted in polyposis 2.5 , protein phosphatase 1, regulatory subunit 46 , adenomatous polyposis coli homolog

GENE ID SPECIES
100064431 Equus caballus
461999 Pan troglodytes
479139 Canis lupus familiaris
779466 Xenopus (Silurana) tropicalis
8350424 Schistosoma mansoni
11789 Mus musculus
324 Homo sapiens
24205 Rattus norvegicus
100517932 Sus scrofa
533233 Bos taurus
399455 Xenopus laevis
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