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The activation of canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling by deletion of Apc in cardiomyocytes led to ventricular hyperplasia.
demonstrated that despite having both Kras and Pik3ca (show PIK3CA Proteins) mutations at the time of tumor initiation from loss of APC
Suggest that the early activation of Hsf1 (show HSF1 Proteins) dependent cell stress pathway by mono-allelic mutations in APC can affect cell programming in a way that contributes to cancer onset.
Adenomatous polyposis coli mutation leads to myopia development in mice.
findings indicate Ctnnb1 (show CTNNB1 Proteins) gene dose exerts tissue-specific differences in Apc mutation-instigated tumorigenesis
Microsatellite instability in the Apc gene does not significantly affect chlorinated water-induced colonic tumorigenesis.
Lung mesenchyme-specific Apc conditional knockout resulted in abnormal lung morphogenesis and fetal lethality at mid-gestation.
our results suggest that both T cell development in a functional thymus and IL-17A (show IL17A Proteins) control the ability of Treg to inhibit intestinal tumorigenesis in Apc (/Min+) mice.
the effect of Apc loss in MMTV-PyMT mouse breast cancer cells on gene expression changes of ATP-binding cassette transporters and immunofluorescence to determine proliferative and apoptotic response of cells to cisplatin, doxorubicin and paclitaxel
The results demonstrate that in muscle stem cells, APC dampens canonical Wnt (show WNT2 Proteins) signaling to allow cell cycle progression. And that APC is absolutely necessary for regenerative myogenesis.
Full-length APC promotes assembly of the Miro-1 (show RHOT1 Proteins)/Milton-2 complex.
Studied promoter methylation of ITF2 (show TCF4 Proteins) and APC and associated microsatellite instability in two case-case studies nested in colorectal cancer.
While binding to gamma-tubulin (show TUBG1 Proteins) may help target APC to the site of microtubule nucleation complexes, additional C-terminal sequences of APC are required to stimulate and stabilize microtubule growth.
Our data represent the first comprehensive study delineating the mutation spectra of both APC and MUTYH (show MUTYH Proteins) in Hungarian familial adenomatous polyposis families
As depicted in Figure 3, APC (25%) followed by KRAS (20%), TP53 (show TP53 Proteins) (14%), and PIK3CA (show PIK3CA Proteins) (11%) were the most frequently mutated genes.
APC I1307K variant was associated with an increased risk of colorectal cancer among Egyptian subjects.
APC c.3956delC mutation is a strong candidate biomarker of familial adenomatous polyposis in families of northern Brazil.
in 25% (5/20) of patients with colorectal adenomatous polyposis, somatic mosaicism of a pathogenic APC mutation was identified as underlying cause of the disease; data indicate a high prevalence of pathogenic mosaic APC mutations below the detection thresholds of routine diagnostics in adenomatous polyposis
analysis of the causative APC gene defects associated with familial adenomatous coli in a Chinese pedigree
A male-specific association of the APC rs383830 polymorphism with coronary heart disease in the Chinese population has been found.
the Amer2 (show AMER2 Proteins)-EB1 (show MAPRE1 Proteins)-APC complex regulates cell migration by altering microtubule stability.
Data show that importin-beta (show KPNB1 Proteins) binds to Apc and negatively regulates the MT-assembly and spindle-promoting activity of Apc in a Ran-regulatable manner.
APC and Axin (show AXIN1 Proteins) are involved in the Wnt (show WNT2 Proteins) pathway
depletion of APC from cystostatic factor (CSF (show CSF2 Proteins)) Xenopus extracts leads to a decrease in microtubule density and changes in tubulin (show TUBB Proteins) distribution in spindles and asters formed in such extracts
An interaction of tumor-associated N-terminal APC fragments (N-APC) with Mad2 (show MAD2L1 Proteins), an essential mitotic checkpoint (show BUB3 Proteins) protein, providing a direct molecular support for linking APC mutations to the generation of chromosome instability, is reported.
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
adenomatosis polyposis coli
, adenomatous polyposis coli protein
, multiple intestinal neoplasia
, adenomatosis polyposis coli tumor suppressor
, deleted in polyposis 2.5
, protein phosphatase 1, regulatory subunit 46
, adenomatous polyposis coli homolog