Browse our Adenomatous Polyposis Coli Proteins (APC)

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Adenomatous Polyposis Coli Proteins (APC)
On www.antibodies-online.com are 4 Adenomatous Polyposis Coli (APC) Proteins from 2 different suppliers available. Additionally we are shipping Adenomatous Polyposis Coli Antibodies (201) and Adenomatous Polyposis Coli Kits (18) and many more products for this protein. A total of 238 Adenomatous Polyposis Coli products are currently listed.
Synonyms:
AI047805, APC1, AU020952, AW124434, BTPS2, CC1, DP2, DP2.5, DP3, fap, fpc, GS, mAPC, Min, PPP1R46, RATAPC, xapc
list all proteins Gene Name GeneID UniProt
APC 11789  
APC 324 P25054
APC 24205 P70478

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Adenomatous Polyposis Coli Proteins (APC) by Origin

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Mouse (Murine) Adenomatous Polyposis Coli (APC) interaction partners

  1. Msi-1 (show MSI1 Proteins) contributes to intestinal tumorigenesis driven by Apc loss, and validate the pursuit of Msi-1 (show MSI1 Proteins) inhibitors as chemo-prevention agents to reduce tumor burden.

  2. APC haploinsufficiency coupled with p53 (show TP53 Proteins) deletion resulted in the development of a distinct type of pancreatic premalignant precursors, mucinous cystic neoplasms (MCNs)

  3. Gasdermin C is upregulated by inactivation of Tgfbr2 (show TGFBR2 Proteins) in the presence of mutated Apc, promoting colorectal cancer cell proliferation.

  4. By sequencing Apc and Ctnnb1 (show CTNNB1 Proteins) genes, we found that most PhIP (show PHIP Proteins)-induced small intestinal tumors in obese mice carried only a single heterozygous mutation in Apc . Our findings demonstrate that PhIP (show PHIP Proteins)-induced small intestinal carcinogenesis in hCYP1A-db/db (show LEPR Proteins) mice is promoted by obesity and involves Apc mutation and inactivation by DNA hypermethylation

  5. Elevated coexpression of KITENIN and ErbB4 (show ERBB4 Proteins)-CYT (show CYGB Proteins)-2 promotes the transition of colon adenoma to adenocarcinoma within an APC loss-associated tumor microenvironment

  6. The activation of canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling by deletion of Apc in cardiomyocytes led to ventricular hyperplasia.

  7. demonstrated that despite having both Kras and Pik3ca (show PIK3CA Proteins) mutations at the time of tumor initiation from loss of APC

  8. Suggest that the early activation of Hsf1 (show HSF1 Proteins) dependent cell stress pathway by mono-allelic mutations in APC can affect cell programming in a way that contributes to cancer onset.

  9. Adenomatous polyposis coli mutation leads to myopia development in mice.

  10. findings indicate Ctnnb1 (show CTNNB1 Proteins) gene dose exerts tissue-specific differences in Apc mutation-instigated tumorigenesis

Human Adenomatous Polyposis Coli (APC) interaction partners

  1. Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium

  2. Finally, we observed that expression of miR-19a significantly correlates with beta-catenin levels in colorectal cancer specimens, and it is associated to the aggressive stage of tumor progression. Thus, our study reveals that miR-17-92 cluster is directly regulated by APC/b-catenin pathway and could be a potential therapeutic target in colon cancers with aberrant APC/b-catenin signaling.

  3. Findings show that colorectal Cancer patients-derived cells with short APC mutants were either sensitive or responsive to tankyrase inhibitors corroborating the idea that APC with complete deletion of seven 20-AA repeats could be a predictive biomarker for the sensitivity to tankyrase inhibitors.

  4. Our study showed that mutations in the APC gene alter the protein expression and cell cycle regulation in diffuse type gastric adenocarcinoma.

  5. Gasdermin C is upregulated by inactivation of Tgfbr2 (show TGFBR2 Proteins) in the presence of mutated Apc, promoting colorectal cancer cell proliferation.

  6. Nine patients with 21- approximately 100 colorectal adenomas (50%) and the two positive controls, showed somatic mosaicism, with identical APC variants in adenomas tested.

  7. These result suggested that miR (show MLXIP Proteins)-590-3p can promote osteogenic differentiation via suppressing APC expression and stabilizing beta-catenin (show CTNNB1 Proteins).

  8. The present findings indicate epigenetic silencing of APC in advanced gallbladder cancer (GBC). The methylation pattern, followed by expression analysis of APC may be suggested for diagnostic, prognostic and therapeutic purposes in GBC in future

  9. miR (show MLXIP Proteins)-106a-5p is involved in the invasive behavior of glioblastoma cells and by targeting APC and activating Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway.

  10. Point Mutations in Exon 1B of APC Reveal Similar mutations in APC promoter 1B occur in rare families with familial adenomatous polyposis

Xenopus laevis Adenomatous Polyposis Coli (APC) interaction partners

  1. the Amer2 (show AMER2 Proteins)-EB1 (show MAPRE1 Proteins)-APC complex regulates cell migration by altering microtubule stability.

  2. Data show that importin-beta (show KPNB1 Proteins) binds to Apc and negatively regulates the MT-assembly and spindle-promoting activity of Apc in a Ran-regulatable manner.

  3. APC and Axin (show AXIN1 Proteins) are involved in the Wnt (show WNT2 Proteins) pathway

  4. depletion of APC from cystostatic factor (CSF (show CSF2 Proteins)) Xenopus extracts leads to a decrease in microtubule density and changes in tubulin (show TUBB Proteins) distribution in spindles and asters formed in such extracts

  5. An interaction of tumor-associated N-terminal APC fragments (N-APC) with Mad2 (show MAD2L1 Proteins), an essential mitotic checkpoint (show BUB3 Proteins) protein, providing a direct molecular support for linking APC mutations to the generation of chromosome instability, is reported.

Adenomatous Polyposis Coli (APC) Protein Profile

Protein Summary

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Alternative names and synonyms associated with Adenomatous Polyposis Coli (APC)

  • adenomatous polyposis coli (APC)
  • adenomatous polyposis coli (apc)
  • adenomatous polyposis coli protein (Smp_139190)
  • adenomatosis polyposis coli (Apc)
  • adenomatous polyposis coli (Apc)
  • AI047805 protein
  • APC1 protein
  • AU020952 protein
  • AW124434 protein
  • BTPS2 protein
  • CC1 protein
  • DP2 protein
  • DP2.5 protein
  • DP3 protein
  • fap protein
  • fpc protein
  • GS protein
  • mAPC protein
  • Min protein
  • PPP1R46 protein
  • RATAPC protein
  • xapc protein

Protein level used designations for APC

adenomatosis polyposis coli , adenomatous polyposis coli protein , multiple intestinal neoplasia , adenomatosis polyposis coli tumor suppressor , deleted in polyposis 2.5 , protein phosphatase 1, regulatory subunit 46 , adenomatous polyposis coli homolog

GENE ID SPECIES
100064431 Equus caballus
461999 Pan troglodytes
479139 Canis lupus familiaris
779466 Xenopus (Silurana) tropicalis
8350424 Schistosoma mansoni
11789 Mus musculus
324 Homo sapiens
24205 Rattus norvegicus
100517932 Sus scrofa
533233 Bos taurus
399455 Xenopus laevis
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