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Elevated coexpression of KITENIN and ErbB4 (show ERBB4 Proteins)-CYT (show CYGB Proteins)-2 promotes the transition of colon adenoma to adenocarcinoma within an APC loss-associated tumor microenvironment
The activation of canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling by deletion of Apc in cardiomyocytes led to ventricular hyperplasia.
demonstrated that despite having both Kras and Pik3ca (show PIK3CA Proteins) mutations at the time of tumor initiation from loss of APC
Suggest that the early activation of Hsf1 (show HSF1 Proteins) dependent cell stress pathway by mono-allelic mutations in APC can affect cell programming in a way that contributes to cancer onset.
Adenomatous polyposis coli mutation leads to myopia development in mice.
findings indicate Ctnnb1 (show CTNNB1 Proteins) gene dose exerts tissue-specific differences in Apc mutation-instigated tumorigenesis
Microsatellite instability in the Apc gene does not significantly affect chlorinated water-induced colonic tumorigenesis.
Lung mesenchyme-specific Apc conditional knockout resulted in abnormal lung morphogenesis and fetal lethality at mid-gestation.
our results suggest that both T cell development in a functional thymus and IL-17A (show IL17A Proteins) control the ability of Treg to inhibit intestinal tumorigenesis in Apc (/Min+) mice.
the effect of Apc loss in MMTV-PyMT mouse breast cancer cells on gene expression changes of ATP-binding cassette transporters and immunofluorescence to determine proliferative and apoptotic response of cells to cisplatin, doxorubicin and paclitaxel
Studies suggest that both loss of tumor suppressive function and gain of function of APC mutants play critical roles in colorectal cancers (CRC (show CALR Proteins)) tumorigenesis.
Loss of heterozygosity of TP53 (show TP53 Proteins), P16, SMAD4 (show SMAD4 Proteins) and APC genes was observed in esophageal adenocarcinoma.
miR (show MLXIP Proteins)-582-5P was upregulated in the colorectal cancer specimens and cell lines and targeted the 3' untranslated region of APC directly.
Loss of APC expression through methylation of its promoter is a widespread phenomenon in Wnt (show WNT2 Proteins)//beta-catenin (show CTNNB1 Proteins) activated tumors.
The loss of APC through aberrant CpG promoter methylation is associated with the aggressive behavior of both sporadic and familial breast cancer in Tunisian patients.
GSTP1 (show GSTP1 Proteins), APC and RASSF1 (show RASSF1 Proteins) gene methylation in prostate cancer samples: comparative analysis of MS-HRM method and Infinium HumanMethylation450 BeadChip beadchiparray diagnostic value
Both TIMP3 (show TIMP3 Proteins) and APC methylation were associated with lymph node metastasis and higher clinical stage of tumors. Patients with methylation at TIMP3 (show TIMP3 Proteins) or APC had worse prognoses as compared to those without these alterations.
AXIN1 (show AXIN1 Proteins) is expressed in meningioma along with APC and E-cadherin (show CDH1 Proteins)
we identified three novel mutations as well as two recurrent mutations in the APC in five Chinese familial adenomatous polyposis families
In oral squamous cell carcinoma there is no statistically significant differences in the expression level of MGMT (show MGMT Proteins), p16, and APC genes in tumor samples compared to margin samples.
the Amer2 (show AMER2 Proteins)-EB1 (show MAPRE1 Proteins)-APC complex regulates cell migration by altering microtubule stability.
Data show that importin-beta (show KPNB1 Proteins) binds to Apc and negatively regulates the MT-assembly and spindle-promoting activity of Apc in a Ran-regulatable manner.
APC and Axin (show AXIN1 Proteins) are involved in the Wnt (show WNT2 Proteins) pathway
depletion of APC from cystostatic factor (CSF (show CSF2 Proteins)) Xenopus extracts leads to a decrease in microtubule density and changes in tubulin (show TUBB Proteins) distribution in spindles and asters formed in such extracts
An interaction of tumor-associated N-terminal APC fragments (N-APC) with Mad2 (show MAD2L1 Proteins), an essential mitotic checkpoint (show BUB3 Proteins) protein, providing a direct molecular support for linking APC mutations to the generation of chromosome instability, is reported.
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
adenomatosis polyposis coli
, adenomatous polyposis coli protein
, multiple intestinal neoplasia
, adenomatosis polyposis coli tumor suppressor
, deleted in polyposis 2.5
, protein phosphatase 1, regulatory subunit 46
, adenomatous polyposis coli homolog