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Browse our Adenomatous Polyposis Coli Proteins (APC)

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Adenomatous Polyposis Coli Proteins (APC)
On are 4 Adenomatous Polyposis Coli (APC) Proteins from 2 different suppliers available. Additionally we are shipping Adenomatous Polyposis Coli Antibodies (155) and Adenomatous Polyposis Coli Kits (17) and many more products for this protein. A total of 190 Adenomatous Polyposis Coli products are currently listed.
AI047805, APC1, AU020952, AW124434, BTPS2, CC1, DP2, DP2.5, DP3, fap, fpc, GS, mAPC, Min, PPP1R46, RATAPC, xapc
list all proteins Gene Name GeneID UniProt
APC 11789  
APC 324 P25054
APC 24205 P70478

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Adenomatous Polyposis Coli Proteins (APC) by Origin

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More Proteins for Adenomatous Polyposis Coli Interaction Partners

Mouse (Murine) Adenomatous Polyposis Coli (APC) interaction partners

  1. demonstrated that despite having both Kras and Pik3ca (show PIK3CA Proteins) mutations at the time of tumor initiation from loss of APC

  2. Suggest that the early activation of Hsf1 (show HSF1 Proteins) dependent cell stress pathway by mono-allelic mutations in APC can affect cell programming in a way that contributes to cancer onset.

  3. Adenomatous polyposis coli mutation leads to myopia development in mice.

  4. findings indicate Ctnnb1 (show CTNNB1 Proteins) gene dose exerts tissue-specific differences in Apc mutation-instigated tumorigenesis

  5. Microsatellite instability in the Apc gene does not significantly affect chlorinated water-induced colonic tumorigenesis.

  6. Lung mesenchyme-specific Apc conditional knockout resulted in abnormal lung morphogenesis and fetal lethality at mid-gestation.

  7. our results suggest that both T cell development in a functional thymus and IL-17A (show IL17A Proteins) control the ability of Treg to inhibit intestinal tumorigenesis in Apc (/Min+) mice.

  8. the effect of Apc loss in MMTV-PyMT mouse breast cancer cells on gene expression changes of ATP-binding cassette transporters and immunofluorescence to determine proliferative and apoptotic response of cells to cisplatin, doxorubicin and paclitaxel

  9. The results demonstrate that in muscle stem cells, APC dampens canonical Wnt (show WNT2 Proteins) signaling to allow cell cycle progression. And that APC is absolutely necessary for regenerative myogenesis.

  10. APC loss leads to a DNA damage signature and genomic instability in the liver and additional loss of p53 (show TP53 Proteins) leads to an increase in the DNA damage signal but not to an immediate increase in the genomic instability phenotype.

Human Adenomatous Polyposis Coli (APC) interaction partners

  1. in 25% (5/20) of patients with colorectal adenomatous polyposis, somatic mosaicism of a pathogenic APC mutation was identified as underlying cause of the disease; data indicate a high prevalence of pathogenic mosaic APC mutations below the detection thresholds of routine diagnostics in adenomatous polyposis

  2. analysis of the causative APC gene defects associated with familial adenomatous coli in a Chinese pedigree

  3. A male-specific association of the APC rs383830 polymorphism with coronary heart disease in the Chinese population has been found.

  4. Suggest that the early activation of Hsf1 (show HSF1 Proteins) dependent cell stress pathway by mono-allelic mutations in APC can affect cell programming in a way that contributes to cancer onset.

  5. APC promoter methylation is associated with the risk of hepatocellular carcinoma.

  6. A founder mutation within the APC promoter is associated with familial adenomatous polyposis in the United States.

  7. GSK3 acts through APC motifs R2 and B to regulate APC:Axin interactions, promoting high-throughput of betacatenin to destruction.

  8. Expression of APC is decreased in mutation negative cases and this appears to be a promising indicator of FAP predisposition, while for MUTYH (show MUTYH Proteins) gene, mutation is associated to reduced mRNA expression.

  9. two novel mutations in APC gene identified in Chinese families with familial adenomatous polyposis.

  10. shows that RAR-beta (show RARB Proteins) methylation detected in lung tissue may be used as a predictive marker for non-small cell lung cancer diagnosis and that APC methylation in tumor sample may be a useful marker

Xenopus laevis Adenomatous Polyposis Coli (APC) interaction partners

  1. the Amer2 (show AMER2 Proteins)-EB1 (show MAPRE1 Proteins)-APC complex regulates cell migration by altering microtubule stability.

  2. Data show that importin-beta (show KPNB1 Proteins) binds to Apc and negatively regulates the MT-assembly and spindle-promoting activity of Apc in a Ran-regulatable manner.

  3. APC and Axin (show AXIN1 Proteins) are involved in the Wnt (show WNT2 Proteins) pathway

  4. depletion of APC from cystostatic factor (CSF (show CSF2 Proteins)) Xenopus extracts leads to a decrease in microtubule density and changes in tubulin (show TUBB Proteins) distribution in spindles and asters formed in such extracts

  5. An interaction of tumor-associated N-terminal APC fragments (N-APC) with Mad2 (show MAD2L1 Proteins), an essential mitotic checkpoint (show BUB3 Proteins) protein, providing a direct molecular support for linking APC mutations to the generation of chromosome instability, is reported.

Adenomatous Polyposis Coli (APC) Protein Profile

Protein Summary

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Alternative names and synonyms associated with Adenomatous Polyposis Coli (APC)

  • adenomatous polyposis coli (APC)
  • adenomatous polyposis coli (apc)
  • adenomatous polyposis coli protein (Smp_139190)
  • adenomatosis polyposis coli (Apc)
  • adenomatous polyposis coli (Apc)
  • AI047805 protein
  • APC1 protein
  • AU020952 protein
  • AW124434 protein
  • BTPS2 protein
  • CC1 protein
  • DP2 protein
  • DP2.5 protein
  • DP3 protein
  • fap protein
  • fpc protein
  • GS protein
  • mAPC protein
  • Min protein
  • PPP1R46 protein
  • RATAPC protein
  • xapc protein

Protein level used designations for APC

adenomatosis polyposis coli , adenomatous polyposis coli protein , multiple intestinal neoplasia , adenomatosis polyposis coli tumor suppressor , deleted in polyposis 2.5 , protein phosphatase 1, regulatory subunit 46 , adenomatous polyposis coli homolog

100064431 Equus caballus
461999 Pan troglodytes
479139 Canis lupus familiaris
779466 Xenopus (Silurana) tropicalis
8350424 Schistosoma mansoni
11789 Mus musculus
324 Homo sapiens
24205 Rattus norvegicus
100517932 Sus scrofa
533233 Bos taurus
399455 Xenopus laevis
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