APC Products
(Adenomatous Polyposis Coli (APC))
Categories
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008].
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Featured APC Categories
APC Antibodies
High quality antibodies with extensive validation data.
APC ELISA Kits
Reliable ELISA kits for a wide range of species.
APC Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended APC Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7439342
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
IHC, IF
Validations
- (5)
Cat. No.
ABIN7260669
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN1678690
Quantity
100 μg
Datasheet
Datasheet
Recommended APC ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6953476
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6964614
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953477
Quantity
96 tests
Datasheet
Datasheet
Recommended APC Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121704
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345292
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505206
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our APC products
: "Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum." in: Nature communications, Vol. 9, Issue 1, pp. 2830, (2018) (PubMed).: "Comparison of Selected Protein Levels in Tumour and Surgical Margin in a Group of Patients with Oral Cavity Cancer." in: Biochemical genetics, Vol. 55, Issue 4, pp. 322-334, (2017) (PubMed).
: "Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer." in: Experimental biology and medicine (Maywood, N.J.), Vol. 241, Issue 14, pp. 1531-9, (2017) (PubMed).
: "Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis." in: Oncogene, (2016) (PubMed).
: "Genetic reconstitution of tumorigenesis in primary intestinal cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 27, pp. 11127-32, (2013) (PubMed).
: "Plasma membrane recruitment of dephosphorylated beta-catenin upon activation of the Wnt pathway." in: Journal of cell science, Vol. 121, Issue Pt 11, pp. 1793-802, (2008) (PubMed).
: "Cadherins, catenins and APC in pleural malignant mesothelioma." in: The Journal of pathology, Vol. 201, Issue 3, pp. 355-62, (2003) (PubMed).
Synonyms and alternative names related to APC
APC, WNT signaling pathway regulator (APC), adenomatous polyposis coli (apc), adenomatous polyposis coli protein, putative (Smp_139190), adenomatosis polyposis coli (Apc), APC, WNT signaling pathway regulator (Apc), adenomatous polyposis coli L homeolog (apc.L), AI047805, APC1, AU020952, AW124434, BTPS2, CC1, dp2, DP2, dp2.5, DP2.5, dp3, DP3, fap, fpc, GS, mAPC, Min, PPP1R46, RATAPC, xapcProtein level used designations for APC
- adenomatosis polyposis coli
- adenomatous polyposis coli protein
- multiple intestinal neoplasia
- adenomatosis polyposis coli tumor suppressor
- deleted in polyposis 2.5
- protein phosphatase 1, regulatory subunit 46
- adenomatous polyposis coli homolog
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