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epigenetic silencing of Wnt (show WNT2 Proteins) antagonists was associated with gastric carcinogenesis, and concurrent hypermethylation of SFRP2 (show SFRP2 Proteins) and DKK2 could be a potential marker for a prognosis of poor overall survival.
the genotyping and functional findings are consistent with the hypothesis that DKK2 is a tumor suppressor; by selectively retaining a transcriptionally inactive DKK2 allele, the reduction of DKK2 function results in unchecked Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling, contributing to hepatocellular carcinoma oncogenesis.
The present report suggested that DKK2 downregulation suppressed the proliferation and invasion of prostate cancer cells by inhibiting the Wnt/betacatenin signaling pathway.
these findings reveal that the miR (show MLXIP Proteins)-187-5p-DKK2 pathway regulates Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling, cell growth, and apoptosis. Our findings provide the first evidence of a role for miR (show MLXIP Proteins)-187-5p in promotion of B-cell ALL.
Genetic variant in DKK2 gene is associated with gallbladder cancer.
targeting of DKK2 by miR (show MLXIP Proteins)-154 leads to upregulation of beta-catenin (show CTNNB1 Proteins) expression and activation of the classical Wnt (show WNT2 Proteins) signaling pathway and cardiac fibroblasts.
MiR (show MLXIP Proteins)-21 overexpression was significantly correlated with the DKK2-/beta-catenin (show CTNNB1 Proteins)- immunohistochemical phenotype.
Data indicate that inhibiting dickkopf-related protein 2 (DKK2)with siDKK2 reduced the expression of DKK2, but had no effect on leptin (show LEP Proteins) expression.
We found 1 DKK2 SNP to be significantly associated with alcohol-related harm in alcoholic subjects
a new regulatory mechanism of miR (show MLXIP Proteins)-222
Spermatogenesis-associated protein 3 (Spata3) and dickkopf-related protein 2 (Dkk2) were confirmed to interact with MIC3. The tandem repeat EGF (show EGF Proteins) domains of MIC3 were critical in mediating the interactions with the identified host proteins. The results show that MIC3 interacts with host proteins that are involved in reproduction, growth, and development.
these data reveal a novel mechanism that the Bmp4 (show BMP4 Proteins)-Msx1 (show MSX1 Proteins) pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt (show WNT2 Proteins) antagonists.
These findings demonstrate that DKK1 (show DKK1 Proteins) and DKK2 have differential roles in normalization and functionality of tumor blood vessels, in addition to angiogenesis.
Bmp4 (show BMP4 Proteins) signaling suppresses tooth developmental inhibitors in the tooth mesenchyme, including Dkk2 and Osr2, and synergizes with Msx1 (show MSX1 Proteins) to activate mesenchymal odontogenic potential for tooth morphogenesis and sequential tooth formation
Dickkopf2 is a Wnt (show WNT2 Proteins) antagonist involved in regulation of glucose metabolism
Both Dkk1 (show DKK1 Proteins) and Dkk2 inhibit Wnt (show WNT2 Proteins) signaling that regulates early myocardial proliferation; each compensates for loss of the other in that role.
there are distinct functions of DKK1 (show DKK1 Proteins) and DKK2 in controlling angiogenesis
Dkk2 was localized in the perichondral mesenchyme outlining the anterior cranial base in embryogenesis.
Dkk2 is a key regulator of the corneal versus epidermal fate of the ocular surface epithelium
WNT (show WNT2 Proteins) signaling attenuation by DKK-1 (show DKK1 Proteins) and -2 regulates BMP2 (show BMP2 Proteins)-induced osteoblast differentiation and expression of OPG (show TNFSF11 Proteins), RANKL (show TNFSF11 Proteins) and M-CSF (show CSF1R Proteins)
the DKK2 gene might have potential effects on body measurement traits and meat quality traits in Qinchuan cattle.
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).
dickkopf 2 homolog
, dickkopf homolog 2
, dickkopf related protein-2
, dickkopf-related protein 2
, dickkopf 1 homolog
, dickkopf homolog 1
, dickkopf-like protein 1
, dickkopf-related protein 1
, dickkopf 2
, dickkopf homolog 4