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Browse our DKK2 Proteins (DKK2)

Full name:
Dickkopf 2 Homolog (Xenopus Laevis) Proteins (DKK2)
On are 15 Dickkopf 2 Homolog (Xenopus Laevis) (DKK2) Proteins from 9 different suppliers available. Additionally we are shipping DKK2 Antibodies (73) and DKK2 Kits (28) and many more products for this protein. A total of 123 DKK2 products are currently listed.
DKK-2, Dkk4
list all proteins Gene Name GeneID UniProt
DKK2 56811 Q9QYZ8
DKK2 27123 Q9UBU2
Rat DKK2 DKK2 295445  

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DKK2 Proteins (DKK2) by Origin

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Top referenced DKK2 Proteins

  1. Human DKK2 Protein expressed in Escherichia coli (E. coli) - ABIN1098672 : Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ... in Genome research 2003 (PubMed)
    Show all 2 references for ABIN1098672

More Proteins for DKK2 Interaction Partners

Cow (Bovine) Dickkopf 2 Homolog (Xenopus Laevis) (DKK2) interaction partners

  1. the DKK2 gene might have potential effects on body measurement traits and meat quality traits in Qinchuan cattle.

Mouse (Murine) Dickkopf 2 Homolog (Xenopus Laevis) (DKK2) interaction partners

  1. These findings demonstrate that DKK1 (show DKK1 Proteins) and DKK2 have differential roles in normalization and functionality of tumor blood vessels, in addition to angiogenesis.

  2. Bmp4 (show BMP4 Proteins) signaling suppresses tooth developmental inhibitors in the tooth mesenchyme, including Dkk2 and Osr2, and synergizes with Msx1 (show MSX1 Proteins) to activate mesenchymal odontogenic potential for tooth morphogenesis and sequential tooth formation

  3. Dickkopf2 is a Wnt (show WNT2 Proteins) antagonist involved in regulation of glucose metabolism

  4. Both Dkk1 (show DKK1 Proteins) and Dkk2 inhibit Wnt (show WNT2 Proteins) signaling that regulates early myocardial proliferation; each compensates for loss of the other in that role.

  5. there are distinct functions of DKK1 (show DKK1 Proteins) and DKK2 in controlling angiogenesis

  6. Dkk2 was localized in the perichondral mesenchyme outlining the anterior cranial base in embryogenesis.

  7. Dkk2 is a key regulator of the corneal versus epidermal fate of the ocular surface epithelium

  8. WNT (show WNT2 Proteins) signaling attenuation by DKK-1 (show DKK1 Proteins) and -2 regulates BMP2 (show BMP2 Proteins)-induced osteoblast differentiation and expression of OPG (show TNFSF11 Proteins), RANKL (show TNFSF11 Proteins) and M-CSF (show CSF1R Proteins)

  9. These data suggest that activation of Dkk2 by PITX2 (show PITX2 Proteins) provides a mechanism to locally suppress canonical Wnt (show WNT2 Proteins) signaling activity during eye development

  10. analysis of the structural basis of the interaction between Dkk (show DKK1 Proteins) and low density lipoprotein receptor (show LDLR Proteins)-related protein (LRP (show LRP1 Proteins)) 5 (show LRP5 Proteins)/6

Human Dickkopf 2 Homolog (Xenopus Laevis) (DKK2) interaction partners

  1. these findings reveal that the miR (show MLXIP Proteins)-187-5p-DKK2 pathway regulates Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling, cell growth, and apoptosis. Our findings provide the first evidence of a role for miR (show MLXIP Proteins)-187-5p in promotion of B-cell ALL.

  2. Genetic variant in DKK2 gene is associated with gallbladder cancer.

  3. targeting of DKK2 by miR (show MLXIP Proteins)-154 leads to upregulation of beta-catenin (show CTNNB1 Proteins) expression and activation of the classical Wnt (show WNT2 Proteins) signaling pathway and cardiac fibroblasts.

  4. MiR (show MLXIP Proteins)-21 overexpression was significantly correlated with the DKK2-/beta-catenin (show CTNNB1 Proteins)- immunohistochemical phenotype.

  5. Data indicate that inhibiting dickkopf-related protein 2 (DKK2)with siDKK2 reduced the expression of DKK2, but had no effect on leptin (show LEP Proteins) expression.

  6. We found 1 DKK2 SNP to be significantly associated with alcohol-related harm in alcoholic subjects

  7. a new regulatory mechanism of miR (show MLXIP Proteins)-222

  8. Our results provide strong evidence that DKK2 is a key player in Ewing sarcoma invasion and osteolysis and also in the differential phenotype of Ewing sarcoma cells.

  9. DKK2 may contribute to tumorigenesis in epithelial ovarian cancer(EOC) through the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling mechanisms.

  10. Elevated TGF-beta1 (show TGFB1 Proteins) levels in osteoarthritic osteoblasts can stimulate DKK2 expression.

DKK2 Protein Profile

Protein Summary

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).

Alternative names and synonyms associated with DKK2

  • dickkopf 2 homolog (Xenopus laevis) (DKK2)
  • dickkopf homolog 2 (Xenopus laevis) (DKK2)
  • dickkopf homolog 2 (Xenopus laevis) (Dkk2)
  • dickkopf WNT signaling pathway inhibitor 2 (DKK2)
  • dickkopf WNT signaling pathway inhibitor 2 (Dkk2)
  • dickkopf-related protein 2-like (LOC100519672)
  • DKK-2 protein
  • Dkk4 protein

Protein level used designations for DKK2

dickkopf homolog 2 , dickkopf-related protein 2 , dickkopf 2 , dickkopf homolog 1 , dickkopf-2 , dkk-2 , mDkk-2 , dickkopf 2 homolog , dickkopf related protein-2 , hDkk-2 , dickkopf homolog 4

478502 Canis lupus familiaris
422531 Gallus gallus
101123633 Ovis aries
541161 Bos taurus
56811 Mus musculus
27123 Homo sapiens
295445 Rattus norvegicus
100715224 Cavia porcellus
100519672 Sus scrofa
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