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Human FRZB Protein expressed in Escherichia coli (E. coli) - ABIN1098735
Baker-Lepain, Lynch, Parimi, McCulloch, Nevitt, Corr, Lane: Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis. in Arthritis and rheumatism 2012
Show all 2 references for ABIN1098735
Stable overexpression of Frzb in MC3T3-E1 cells increased calcium deposition and osteoblast markers compared with control. Western blot analysis showed that the increased osteogenesis was associated with reduced canonical, but increased non-canonical Wnt (show WNT2 Proteins) signaling.
an inverse septal-to-temporal increase in the expression of sfrp3 that emerges during postnatal development, is reported.
The spatiotemporally dynamic expression ofsFRP3 strongly suggests that sFRP3 has potential functions in the sensory neuron genesis and sensory circuitry formation.
Our results suggest that FrzB may have a protective role on cartilage degradation and matrix metalloproteinase (show MMP20 Proteins) induction in mouse chondrocytes
left ventricles from post-MI mice showed an increased sFRP3 mRNA level, particularly in cardiac fibroblasts, and (iv) mechanical stretch enhanced sFRP3 expression and release in myocardial fibroblasts
Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in mice.
Study identifies sFRP3 as an inhibitory niche factor from local mature dentate granule neurons that regulates multiple phases of adult hippocampal neurogenesis.
Data indicate an important role for frizzled-related protein (Frzb) in joint homeostasis and highlight the complex biology of WNT (show WNT2 Proteins) signaling in the joint.
Secreted Frizzled-related proteins (sFrps) are expressed in the postnatal cerebral cortex in regional and lamina patterns in the major subdivisions of the cerebral cortex: the olfactory bulb, the hippocampal formation, and the neocortex.
sFRP3 may stimulate differentiation through a beta (show SUCLA2 Proteins)-catenin (show CTNNB1 Proteins)-independent pathway in addition to its previously known function as a decoy receptor for Wnt's
this study shows that sFRP3 regulates fibroblast-like synociocyte transformation
This may suggest that SFRP3 acts as an agonist of Wnt (show WNT2 Proteins) signaling and promotes invasive behavior.
The secreted frizzled-related protein (show SFRP2 Proteins) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.
FRZB expression was up-regulated in hepatocellular carcinoma bone metastasis tissue, which suggested that FRZB might play a key role in the HCC (show FAM126A Proteins) bone metastasis.
Positive expression of FRZB was statistically significantly associated with poor prognosis of patients with colon carcinoma hepatic metastasis.
Secreted Frizzled-Related Protein 3 (SFRP3) Is Required for Tumorigenesis of PAX3 (show PAX3 Proteins)-FOXO1 (show FOXO1 Proteins)-Positive Alveolar Rhabdomyosarcoma
Intermediate SFRP3 levels are associated with better survival and fewer cardiovascular events than low or high SFRP3 levels, independently of conventional risk factors, in older patients with chronic systolic Heart Failure of ischemic origin.
Intermediate levels of sFRP3 were a predictor of all-cause mortality and re-hospitalization in acute coronary syndromes.
Data suggest secreted FRP3 (frizzled related protein-3 (show HSPB3 Proteins)) interacts with ADAM17 (show ADAM17 Proteins) (A disintegrin/metalloprotease (show ADAM8 Proteins) 17) substrate IL6R (interleukin-6 receptor (show IL6R Proteins)) release; this interaction is down-regulated in osteoarthritis due to rare double variant in FRP3 (show FOLR2 Proteins).
study indicates that increased expression of both SFRP1 (show SFRP1 Proteins) and SFRP3 may contribute to the pathogenesis of IUGR placental dysfunction, whereas the loss of these proteins may be involved in the development of human trophoblastic tumors.
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility.
frizzled-related protein 1
, secreted frizzled-related protein 3
, secreted frizzled-related sequence protein 3
, frizzled homolog-related