FRZB Protein (His tag)
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- Target See all FRZB Proteins
- FRZB (Frizzled-Related Protein (FRZB))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This FRZB protein is labelled with His tag.
- Purpose
- Recombinant Human FRZB/sFRP-3 Protein (His Tag)
- Sequence
- Ala32-Asn325
- Characteristics
- A DNA sequence encoding the human FRZB (NP_001454.2) (Ala32-Asn325) was expressed with a C-terminal polyhistidine tag.
- Purity
- > 85 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product FRZB Protein
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Frizzled-Related Protein (FRZB) (AA 39-760) protein (GST tag)
FRZB Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- FRZB (Frizzled-Related Protein (FRZB))
- Alternative Name
- FRZB/sFRP-3 (FRZB Products)
- Synonyms
- Frp Protein, Sfrp3 Protein, frezzled Protein, fritz Protein, frzb-1 Protein, FRE Protein, FRITZ Protein, FRP-3 Protein, FRZB-1 Protein, FRZB-PEN Protein, FRZB1 Protein, FZRB Protein, OS1 Protein, SFRP3 Protein, SRFP3 Protein, hFIZ Protein, Frzb-1 Protein, frizzled-related protein Protein, Frzb Protein, FRZB Protein
- Background
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Background: FRZB also known as sFRP-3, is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. FRZB is widely expressed in adult mammalian tissues. In the Xenopus gastrula, FRZB is regulated as a typical Spemann organizer component. FRZB also functions as a competitor for the cell-surface G-protein receptor Frizzled. It is espically important in embryonic development. Defects in FRZB gene can cause female-specific osteoarthritis (OA) susceptibility. FRZB may serve an important role in determining hip shape and may modify the relationship between hip shape and OA.
Synonym: FRE,FRITZ,FRP-3,FRZB-1,FRZB-PEN,FRZB1,FZRB,hFIZ,OS1,SFRP3,SRFP3
- Molecular Weight
- 34.5 kDa
- NCBI Accession
- NP_001454
- Pathways
- WNT Signaling, Positive Regulation of fat Cell Differentiation
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