Browse our FZD4 Proteins (FZD4)

Full name:
Frizzled Family Receptor 4 Proteins (FZD4)
On are 15 Frizzled Family Receptor 4 (FZD4) Proteins from 6 different suppliers available. Additionally we are shipping FZD4 Antibodies (134) and FZD4 Kits (8) and many more products for this protein. A total of 170 FZD4 products are currently listed.
anon-WO0170980.10, anon-WO0170980.11, CD344, CG4626, Dfz4, Dmel\\CG4626, Dm Fz4, EVR1, FEVR, frizzled4, FZ-4, fz1, fz4, FZD4S, FzE4, GPCR, hFz4, zg01
list all proteins Gene Name GeneID UniProt
FZD4 8322 Q9ULV1
FZD4 64558 Q9QZH0
FZD4 14366 Q61088

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FZD4 Proteins (FZD4) by Origin

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Top referenced FZD4 Proteins

  1. Human FZD4 Protein expressed in HEK-293 Cells - ABIN2181126 : Sjöblom, Jones, Wood, Parsons, Lin, Barber, Mandelker, Leary, Ptak, Silliman, Szabo, Buckhaults, Farrell, Meeh, Markowitz, Willis, Dawson, Willson, Gazdar, Hartigan, Wu, Liu, Parmigiani, Park et al.: The consensus coding sequences of human breast and colorectal cancers. ... in Science (New York, N.Y.) 2006 (PubMed)
    Show all 2 references for 2181126

More Proteins for FZD4 Interaction Partners

Fruit Fly (Drosophila melanogaster) Frizzled Family Receptor 4 (FZD4) interaction partners

  1. Knockdown of Tc-fz1 alone interfered with the formation of the proximo-distal and the dorso-ventral axes during leg development, whereas no effect was observed with single Tc-fz2 (show FZD2 Proteins) or Tc-fz4 RNAi knockdowns.

Human Frizzled Family Receptor 4 (FZD4) interaction partners

  1. FZD4 down-regulation leads to loss of WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signal activity and subsequently to reduced alveolar epithelial cell wound repair capacity and impaired expression of elastogenic components.

  2. his study showed that Let7b modulates the proliferation, invasiveness, and migration of liver cancer cell and reduces the proportion of cancer stem cells in liver cancer cell by inhibiting Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway via downregulated Frizzled4.

  3. Among the detected mutations, LRP5 (show LRP5 Proteins) accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (show NDP Proteins) (3/31, 9.7%), FZD4 (2/31, 6.5%), TSPAN12 (show TSPAN12 Proteins) (1/31, 3.2%), and KIF11 (show KIF11 Proteins) (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.

  4. human FZD4 assembles-in a DVL-independent manner-with Galpha12/13 but not representatives of other heterotrimeric G protein subfamilies.

  5. Several novel mutations (missense, non-stop (show USP22 Proteins) and insertion) were detected in the coding regions of FZD4, TSPAN12 (show TSPAN12 Proteins) and ZNF408 (show ZNF408 Proteins) genes among the unrelated familial exudative vitreoretinopathy probands. The mutations in FZD4 and TSPAN12 (show TSPAN12 Proteins) were involved in autosomal dominant and autosomal recessive families and further validates the involvement of these gene in exudative vitreoretinopathy development.

  6. Two were novel mutations: p.E134* and p.T503fs of FZD4 lead to the loss of FZD4 activity.

  7. Letter: FZD4+ and FZD4- melanocytes were significantly lower in hair follicles of patients with rhododenol-induced leukoderma.

  8. These structural, biophysical and cellular data, map Fz4 and putative Lrp5 (show LRP5 Proteins)/6 binding sites to distinct patches on Norrin (show NDP Proteins), and reveal a GAG binding site spanning Norrin (show NDP Proteins) and Fz4 cysteine-rich domain.

  9. The relatively high prevalence of the p.[P33S(;)P168S] variant in ROP (show STXBP1 Proteins) (retinopathy of prematurity) and intrauterine growth restriction suggests that it also may be a marker for increased risk of developing ROP (show STXBP1 Proteins) and preterm birth.

  10. Mutations of FZD4 accounted for the largest proportion, which could be directly applied to the testing strategy to start with screening for FZD4 mutations.

Xenopus laevis Frizzled Family Receptor 4 (FZD4) interaction partners

  1. A splice variant of the Frizzled-4 receptor modulates Wnt (show WNT2 Proteins) signalling in a dose-dependent, biphasic manner.

Mouse (Murine) Frizzled Family Receptor 4 (FZD4) interaction partners

  1. Study identified a novel Wnt5a (show WNT5A Proteins)/Fzd4 signaling pathway that contributes to the regulation of dendrite morphogenesis

  2. These results question the conclusion that a dominant-negative mechanism would explain the dominance of the mutant L501fsX533 Fz4 allele in the transmission of a form of Familial exudative vitreoretinopathy.

  3. The data reveal both cell-autonomous and cell-nonautonomous effects, and they imply a central role for Norrin (show NDP Proteins)/Fz4 signaling in central nervous system vascular development and in the maintenance of the blood brain barrier/blood retina barrier state.

  4. Frizzled 4 regulates arterial network organization through noncanonical Wnt (show WNT2 Proteins)/planar cell polarity signaling.

  5. Frizzled4 wnt (show WNT2 Proteins) receptors are significantly increased in pathological neovascularization in a mouse model of oxygen-induced proliferative retinopathy.

  6. targeted inactivation of the TSK (show FBN1 Proteins) gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b (show WNT2B Proteins) and Fzd4 expression in the developing peripheral eye

  7. These results demonstrate that FZD4 is required for physiological and pathologic angiogenesis in the retina and for regulation of retinal endothelial cell differentiation.

  8. A major role for frizzled 4 and frizzled 8 (show FZD8 Proteins) in controlling ureteric growth in the developing kidney.

  9. a Norrin (show NDP Proteins)-Fz4 signaling system plays a central role in vascular development in the eye and ear, and ligands unrelated to Wnts can act through Fz receptors

  10. Fzd4 appears to impact the formation of the corpus luteum

FZD4 Protein Profile

Protein Summary

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.

Alternative names and synonyms associated with FZD4

  • frizzled 4 (fz4)
  • frizzled homolog 4 (fzd4)
  • frizzled-4 (Tsp_10376)
  • frizzled family receptor 4 (FZD4)
  • frizzled family receptor 4 (Fzd4)
  • frizzled family receptor 4 (fzd4)
  • frizzled homolog 4 (Drosophila) (Fzd4)
  • anon-WO0170980.10 protein
  • anon-WO0170980.11 protein
  • CD344 protein
  • CG4626 protein
  • Dfz4 protein
  • Dmel\\CG4626 protein
  • Dm Fz4 protein
  • EVR1 protein
  • FEVR protein
  • frizzled4 protein
  • FZ-4 protein
  • fz1 protein
  • fz4 protein
  • FZD4S protein
  • FzE4 protein
  • GPCR protein
  • hFz4 protein
  • zg01 protein

Protein level used designations for FZD4

CG4626-PA , CG4626-PB , fz4-PA , fz4-PB , frizzled homolog 1 , frizzled-4 , frizzled homolog 4 , WNT receptor frizzled-4 , frizzled 4, seven transmembrane spanning receptor , frizzled receptor 4 , fz-4 , rFz4 , frizzled 4 protein , xfz4 , cFz-4 , mFz4

31659 Drosophila melanogaster
30363 Danio rerio
10902349 Trichinella spiralis
100231781 Taeniopygia guttata
8322 Homo sapiens
64558 Rattus norvegicus
399192 Xenopus laevis
373887 Gallus gallus
485149 Canis lupus familiaris
14366 Mus musculus
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