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FZD4 Products

(Frizzled Family Receptor 4 (FZD4))
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008].

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Featured FZD4 Categories

FZD4 Antibodies

High quality antibodies with extensive validation data.

FZD4 ELISA Kits

Reliable ELISA kits for a wide range of species.

FZD4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended FZD4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, FACS, ICC, Neut
Validations
  • (4)
Cat. No. ABIN7193285
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Cow, Guinea Pig, Horse, Human, Mouse, Rat
Application WB, IHC
Validations
  • (3)
  • (4)
Cat. No. ABIN2776715
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7189418
Quantity 100 μg
Datasheet Datasheet

Recommended FZD4 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966906
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730650
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6227983
Quantity 96 tests
Datasheet Datasheet

Recommended FZD4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354580
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354578
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7195861
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our FZD4 products

Bychkov, Kirichenko, Shulepko, Mikhaylova, Kirpichnikov, Lyukmanova: "Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis." in: Biomedicines, Vol. 9, Issue 10, (2021) (PubMed).

Fu, Wang, Wan, Lin, Chang, Han: "Wnt5a mediated canonical Wnt signaling pathway activation in orthodontic tooth movement: possible role in the tension force-induced bone formation." in: Journal of molecular histology, Vol. 47, Issue 5, pp. 455-66, (2017) (PubMed).

Wang, Pawlak, Johnson, Belknap, Eades, Stack, Cousin, Black: "Impact of laminitis on the canonical Wnt signaling pathway in basal epithelial cells of the equine digital laminae." in: PLoS ONE, Vol. 8, Issue 2, pp. e56025, (2013) (PubMed).

Wirths, Malenke, Kluba, Rieger, Müller, Schleicher, Hann von Weyhern, Nagl, Fend, Vogel, Mayer, Kanz, Bühring, Kopp: "Shared cell surface marker expression in mesenchymal stem cells and adult sarcomas." in: Stem cells translational medicine, Vol. 2, Issue 1, pp. 53-60, (2013) (PubMed).

McIver, Stanger, Santarelli, Roman, Nixon, McLaughlin: "A unique combination of male germ cell miRNAs coordinates gonocyte differentiation." in: PLoS ONE, Vol. 7, Issue 4, pp. e35553, (2012) (PubMed).

Gonzalez, Fernandez-Martos, Gonzalez-Fernandez, Arenas, Rodriguez: "Spatio-temporal expression pattern of frizzled receptors after contusive spinal cord injury in adult rats." in: PLoS ONE, Vol. 7, Issue 12, pp. e50793, (2012) (PubMed).

Despeaux, Chicanne, Rouer, De Toni-Costes, Bertrand, Mansat-De Mas, Vergnolle, Eaves, Payrastre, Girault, Racaud-Sultan: "Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling." in: Stem cells (Dayton, Ohio), Vol. 30, Issue 8, pp. 1597-610, (2012) (PubMed).

Ells, Guernsey, Wallace, Zheng, Vincer, Allen, Ingram, DaSilva, Siebert, Sheidow, Beis, Robitaille: "Severe retinopathy of prematurity associated with FZD4 mutations." in: Ophthalmic genetics, Vol. 31, Issue 1, pp. 37-43, (2010) (PubMed).

Nikopoulos, Venselaar, Collin, Riveiro-Alvarez, Boonstra, Hooymans, Mukhopadhyay, Shears, van Bers, de Wijs, van Essen, Sijmons, Tilanus, van Nouhuys, Ayuso, Hoefsloot, Cremers: "Overview of the mutation spectrum in familial exudative vitreoretinopathy and Norrie disease with identification of 21 novel variants in FZD4, LRP5, and NDP." in: Human mutation, Vol. 31, Issue 6, pp. 656-66, (2010) (PubMed).

Gupta, Iljin, Sara, Mpindi, Mirtti, Vainio, Rantala, Alanen, Nees, Kallioniemi: "FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells." in: Cancer research, Vol. 70, Issue 17, pp. 6735-45, (2010) (PubMed).

Synonyms and alternative names related to FZD4

frizzled 4 (fz4), frizzled class receptor 4 (fzd4), frizzled-4 (Tsp_10376), frizzled class receptor 4 (FZD4), frizzled class receptor 4 (Fzd4), frizzled class receptor 4 S homeolog (fzd4.S), anon-WO0170980.10, anon-WO0170980.11, CD344, CG4626, DFz4, Dfz4, Dmel\\CG4626, Dm Fz4, EVR1, FEVR, frizzled4, Fz-4, FZ-4, fz1, Fz4, fz4, FZD4S, FzE4, GPCR, hFz4, zg01

Protein level used designations for FZD4

  • CG4626-PA
  • CG4626-PB
  • fz4-PA
  • fz4-PB
  • frizzled homolog 1
  • frizzled-4
  • frizzled homolog 4
  • WNT receptor frizzled-4
  • frizzled 4, seven transmembrane spanning receptor
  • frizzled receptor 4
  • fz-4
  • rFz4
  • frizzled 4 protein
  • xfz4
  • cFz-4
  • mFz4
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