Browse our FZD6 Proteins (FZD6)

Full name:
Frizzled Family Receptor 6 Proteins (FZD6)
On are 9 Frizzled Family Receptor 6 (FZD6) Proteins from 3 different suppliers available. Additionally we are shipping FZD6 Antibodies (72) and FZD6 Kits (4) and many more products for this protein. A total of 95 FZD6 products are currently listed.
Frizzled-6, frizzled6, frz6, FZ-6, Fz6, HFZ6, NDNC10, Xfrz6, zgc:65879, zgc:77440
list all proteins Gene Name GeneID UniProt
FZD6 8323 O60353
Rat FZD6 FZD6 282581  
FZD6 14368 Q61089

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FZD6 Proteins (FZD6) by Origin

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More Proteins for FZD6 Interaction Partners

Human Frizzled Family Receptor 6 (FZD6) interaction partners

  1. the FZD6-fibronectin actin axis identified in our study could be exploited for drug development in highly metastatic forms of breast cancer

  2. we found that FZD6 expression was negatively regulated by miR199a5p

  3. The rs3808553 of FZD6 is obviously associated with neural tube defects in Han population of northern China

  4. This study confirms our speculation that down-regulation of FZD6 by beta-Carotene is causally related to the observed up-regulation of cancer related genes

  5. DVL is a master regulator of FZD6/G-protein signaling

  6. FZD6 should be screened for pachyonychia congenita as it is a candidate gene for hereditary nail (show CD244 Proteins) dysplasias.

  7. sequence analysis revealed a novel homozygous missense mutation (c.1266G>A; p.Gly422Asp) located in the transmembrane domain of the protein FZD6 in individuals of a consanguineous family exhibiting features of nail (show CD244 Proteins) dysplasia

  8. The present results emphasize the role of FZD6 mutation in Wnt (show WNT2 Proteins) pathways in nail (show CD244 Proteins) development.

  9. When transplanted into immunodeficient mice, neuroblastoma (show ARHGEF16 Proteins) cells expressing the Fzd6 marker grow more aggressively than their Fzd6 negative counterparts. Fzd6 is a new surface marker of aggressive neuroblastoma (show ARHGEF16 Proteins) cells with stem cell-like features.

  10. This study demonstrates that rare nonsynonymous variants in FZD6 may contribute to NTDs in humans and enlarges the spectrum of mutations that link PCP (show PRCP Proteins) pathway to Neural tube defects (NTDs).

Mouse (Murine) Frizzled Family Receptor 6 (FZD6) interaction partners

  1. Fzd4 (show FZD4 Proteins) and Fzd6 genes have a deep patterning effect on arterial vessel morphogenesis that may determine its functional efficiency

  2. Eliminating Fz6 in most hair follicle cells or in the inter-follicular epidermis at E15.5 suggests that planar cell polarity signaling in developing follicles is not required to maintain their orientation.

  3. Data show that Wnt receptor, Frizzled-6 (Fzd6) -/- hematopoietic stem/progenitor cell (HSPC (show PSMA7 Proteins)) exhibit poor emergency hematopoiesis.

  4. Fz3 (show FZD3 Proteins) and Fz6 have partly interchangeable roles in tissue polarity signaling for epithelial orientation and axon growth and guidance

  5. This study confirms our speculation that down-regulation of FZD6 by beta-Carotene is causally related to the observed up-regulation of cancer related genes

  6. Fzd6-mediated Wnt (show WNT2 Proteins) signaling likely regulates the overall differentiation process of nail (show CD244 Proteins)/claw formation.

  7. Our results support a role of miR (show MLXIP Proteins)-194 in liver tumorigenesis through its endogenous target Fzd6.

  8. FZD6 mutations can result in severe defects in nail (show CD244 Proteins) and claw formation through reduced or abolished membranous FZD(6) levels and several nonfunctional WNT (show WNT2 Proteins)-FZD pathways.

  9. The time course of local hair follicle refinement and the resulting evolution of a montage of competing patterns in Fz6(-/-) skin, is defined.

  10. Downregulated by dietary beta-carotene in lungs of knockout Bcmo1 (show BCMO1 Proteins)-deficient mice.

FZD6 Protein Profile

Protein Summary

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.

Alternative names and synonyms associated with FZD6

  • frizzled homolog 6 (Drosophila) (fzd6)
  • frizzled family receptor 6 (fzd6)
  • frizzled 6 (LOC100344394)
  • frizzled family receptor 6 (FZD6)
  • frizzled family receptor 6 (Fzd6)
  • frizzled homolog 6 (Drosophila) (Fzd6)
  • Frizzled-6 protein
  • frizzled6 protein
  • frz6 protein
  • FZ-6 protein
  • Fz6 protein
  • HFZ6 protein
  • NDNC10 protein
  • Xfrz6 protein
  • zgc:65879 protein
  • zgc:77440 protein

Protein level used designations for FZD6

frizzled-6 , frizzled homolog 6 , frizzled 6 , frizzled 6, seven transmembrane spanning receptor , seven transmembrane helix receptor , fz-6 , involved in Wnt signaling, encoding a Wnt receptor , mFz6

393533 Danio rerio
495007 Xenopus laevis
100344394 Oryctolagus cuniculus
8323 Homo sapiens
403610 Canis lupus familiaris
378788 Gallus gallus
100172142 Pongo abelii
282581 Rattus norvegicus
14368 Mus musculus
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