Browse our anti-GPBAR1 (GPBAR1) Antibodies

Full name:
anti-G Protein-Coupled Bile Acid Receptor 1 Antibodies (GPBAR1)
On www.antibodies-online.com are 111 G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) Antibodies from 13 different suppliers available. Additionally we are shipping GPBAR1 Kits (6) and GPBAR1 Proteins (3) and many more products for this protein. A total of 126 GPBAR1 products are currently listed.
Synonyms:
BG37, CD344, EVR1, FEVR, Fz-4, Fz4, FZD4S, FzE4, Gpbar1, GPCR, GPCR19, GPR131, hFz4, M-BAR, MGC84403, Tgr5
list all antibodies Gene Name GeneID UniProt
GPBAR1 8322 Q9ULV1
GPBAR1 227289 Q80SS6
GPBAR1 338443 Q80T02

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anti-Human GPBAR1 Antibodies:

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anti-Rat (Rattus) GPBAR1 Antibodies:

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More Antibodies against GPBAR1 Interaction Partners

Human G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) interaction partners

  1. FZD4 (show FZD4 Antibodies) down-regulation leads to loss of WNT (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signal activity and subsequently to reduced alveolar epithelial cell wound repair capacity and impaired expression of elastogenic components.

  2. his study showed that Let7b modulates the proliferation, invasiveness, and migration of liver cancer cell and reduces the proportion of cancer stem cells in liver cancer cell by inhibiting Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway via downregulated Frizzled4 (show FZD4 Antibodies).

  3. Among the detected mutations, LRP5 (show LRP5 Antibodies) accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (show NDP Antibodies) (3/31, 9.7%), FZD4 (show FZD4 Antibodies) (2/31, 6.5%), TSPAN12 (show TSPAN12 Antibodies) (1/31, 3.2%), and KIF11 (show KIF11 Antibodies) (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.

  4. bile acids promote intestinal epithelial cell proliferation and decrease mucosal injury by upregulating TGR5 expression in obstructive jaundice.

  5. The generated contour maps revealed the important structural insights for the activity of the compounds. The results obtained from this study could be helpful in the development of novel and more potent agonists of TGR5.

  6. human FZD4 assembles-in a DVL-independent manner-with Galpha12/13 but not representatives of other heterotrimeric G protein subfamilies.

  7. TGR5 functions as a tumor-suppressor in patients with ampullary adenocarcinoma and preoperative hyperbilirubinemia

  8. We conclude that Claudin-2 (show CLDN2 Antibodies) expression is significantly associated with bile acid receptors VDR (show CYP27B1 Antibodies) and TGR5 expression. Our studies identify a novel role of a tight junction protein (show OCLN Antibodies) in the development and progression of esophageal mucosal metaplasia, dysplasia and carcinoma.

  9. Several novel mutations (missense, non-stop (show USP22 Antibodies) and insertion) were detected in the coding regions of FZD4 (show FZD4 Antibodies), TSPAN12 (show TSPAN12 Antibodies) and ZNF408 (show ZNF408 Antibodies) genes among the unrelated familial exudative vitreoretinopathy probands. The mutations in FZD4 (show FZD4 Antibodies) and TSPAN12 (show TSPAN12 Antibodies) were involved in autosomal dominant and autosomal recessive families and further validates the involvement of these gene in exudative vitreoretinopathy development.

  10. this is the first report of bile acid derivatives able to antagonize GPBAR1 and and farnesoid X receptor (show xpr1 Antibodies) (FXR (show NR1H4 Antibodies)) modulatory activity.

Mouse (Murine) G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) interaction partners

  1. Data suggest that FXR (show NR1H4 Antibodies) and TGR5 expression is down-regulated in aging kidney; caloric restriction prevents these age-related changes. Additionally, in long-lived Ames dwarf (show PROP1 Antibodies) mice, renal FXR (show NR1H4 Antibodies) and TGR5 expression is up-regulated. Treatment of aged mice with dual FXR (show NR1H4 Antibodies)/TGR5 agonist reverses age-related changes in kidney structure/function. (FXR (show NR1H4 Antibodies) = farnesoid X activated receptor (show NR1H4 Antibodies); TGR5 = G protein-coupled bile acid receptor 1)

  2. GPBAR1/TGR5 receptor agonist, tauroursodeoxycholic acid, has anti-inflammatory effects in microglial cells.

  3. Vertical sleeve gastrectomy achieves its postoperative therapeutic effects through enhanced TGR5 signaling.

  4. These results suggest that TGR5 contributes to the glucoregulatory benefits of vertical sleeve gastrectomy surgery by promoting metabolically favourable shifts in the circulating bile acid pool.

  5. findings uncovered a novel mechanism in which INT-767 activation of FXR (show NR1H4 Antibodies) induces Tgr5 gene expression and increases Ca(2 (show CA2 Antibodies)+) levels and cAMP activity to stimulate GLP-1 (show GCG Antibodies) secretion and improve hepatic glucose and lipid metabolism in high-fat diet-induced obese mice.

  6. The results suggest that TGR5 activation mediates cross-talk between alpha- and beta-cells by switching from glucagon (show GCG Antibodies) to GLP-1 (show GCG Antibodies) to restore beta- cell mass and function under hyperglycemic conditions.

  7. TGR5 is an important mediator of bile acid-induced cholangiocyte proliferation in vivo and in vitro. Furthermore, TGR5 protects cholangiocytes from death receptor-mediated apoptosis.

  8. miR (show MLXIP Antibodies)-26a is a target gene of bile acid receptor (show NR1H4 Antibodies) GPBAR-1/TGR5

  9. Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling

  10. Data show that the action of bile acids on -like peptide-1 (GLP-1 (show GCG Antibodies)) secretion is predominantly mediated by G protein-coupled bile acid receptor (show NR1H4 Antibodies) GPBAR1 (TGR5) located on the basolateral L-cell membrane.

Cow (Bovine) G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) interaction partners

  1. TGR5 agonism induces NO production via Akt (show AKT1 Antibodies) activation and intracellular Ca(2 (show CA2 Antibodies)+) increase in vascular endothelial cells, and this function inhibits monocyte adhesion in response to inflammatory stimuli.

Rabbit G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) interaction partners

  1. TGR5 has been linked to signaling pathways involved in metabolism, cell survival, proliferation and apoptosis, which suggest a possible role of TGR5 in cancer development.

GPBAR1 Antigen Profile

Antigen Summary

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.

Alternative names and synonyms associated with GPBAR1

  • G protein-coupled bile acid receptor 1 (gpbar1) antibody
  • G protein-coupled bile acid receptor 1 (GPBAR1) antibody
  • frizzled family receptor 4 (FZD4) antibody
  • G protein-coupled bile acid receptor 1 (Gpbar1) antibody
  • G protein-coupled receptor (TGR5) antibody
  • BG37 antibody
  • CD344 antibody
  • EVR1 antibody
  • FEVR antibody
  • Fz-4 antibody
  • Fz4 antibody
  • FZD4S antibody
  • FzE4 antibody
  • Gpbar1 antibody
  • GPCR antibody
  • GPCR19 antibody
  • GPR131 antibody
  • hFz4 antibody
  • M-BAR antibody
  • MGC84403 antibody
  • Tgr5 antibody

Protein level used designations for GPBAR1

G protein-coupled bile acid receptor 1 , G-protein coupled bile acid receptor BG37 , WNT receptor frizzled-4 , frizzled 4, seven transmembrane spanning receptor , frizzled homolog 4 , frizzled-4 , G-protein coupled bile acid receptor 1 , G-protein coupled receptor GPCR19 , hBG37 , hGPCR19 , membrane bile acid receptor , membrane-type receptor for bile acids , G protein-coupled receptor TGR5 , G protein-coupled receptor , M-BAR

GENE ID SPECIES
447779 Xenopus laevis
488521 Canis lupus familiaris
697937 Macaca mulatta
741111 Pan troglodytes
8322 Homo sapiens
151306 Homo sapiens
227289 Mus musculus
338443 Rattus norvegicus
317756 Bos taurus
100009346 Oryctolagus cuniculus
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