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We found that IGFBP6 and SATB2 (show SATB2 Proteins) were significantly down-regulated in HIV-infected CEM*174 cells and 3 different cohorts of HIV/AIDS patients while their promoters were predominantly hyper-methylated compared with normal controls.
IGFBP6 attenuation in ACTH (show POMC Proteins)-secreting pituitary adenomas is associated with tumor growth, through activation of PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) pathway
CCL-18 (show CCL18 Proteins) and IGFBP-6 were identified as new potential serum biomarkers for prostate cancer.
When the concentrations of IGFBP-6 or KNG1 (show KNG1 Proteins) were greater than 98.5 pg/ml or 88.5 ng/ml, respectively, they predicted the proliferative vitreoretinopathy prognosis.
Our results indicate that IGF2 and IGFBP6 appear to govern various regulatory feedback mechanisms in periodontal ligament cells
Data indicate that IGFBP-6 binds to prohibitin-2 (show PHB2 Proteins) on the cell membrane, and knockdown of the latter abrogates IGFBP-6-induced migration.
This is the first report to implicate IGFBP-6 as a suppressor of cellular proliferation and IGF-II as an inducer of cellular contractility in this connective tissue disease.
Review of the IGF system in physiology and disease with a focus on the regulation and actions of IGFBP-6, and its potential roles in cancer cells.
These results suggest that the expression of IGFBP-6 in vascular endothelial cells is up-regulated by hypoxia and IGFBP-6 inhibits angiogenesis in vitro and in vivo
IGFBP-6 acts as a inhibitory mediator of thyroid hormone (show PTH Proteins) effects in osteoblast differentiation
Genome-wide methylation analysis showed that two genes with hypomethylated promoters, Igfbp6 and Foxs1, are upregulated in GDX (show UBL4A Proteins)-induced adrenocortical neoplasms.
Igfbp-6 is a target of sonic hedgehog (show SHH Proteins) signaling in the urogenital sinus
These results reveal a novel function for MMP-9 (show MMP9 Proteins) and -12 in developmental myelination likely through regulating IGF-1 (show IGF1 Proteins) bioavailability.
Report multiple post-translational modifications of mouse insulin-like growth factor binding protein-6 expressed in epithelial Madin-Darby canine kidney cells.
high-affinity IGF binding ptotein with substantially greater affinity for insulin-like growth factor-II (IGF-II) than IGF-I
insulin-like growth factor binding protein 6
, IGF binding protein 6
, IGF-binding protein 6
, insulin-like growth factor-binding protein 6
, INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 6 PRECURSOR (IGFBP-6) (IBP-6) (IGF-BINDING PROTEIN 6)