Browse our LLGL2 Proteins (LLGL2)

Full name:
Lethal Giant Larvae Homolog 2 (Drosophila) Proteins (LLGL2)
On are 5 Lethal Giant Larvae Homolog 2 (Drosophila) (LLGL2) Proteins from 3 different suppliers available. Additionally we are shipping LLGL2 Antibodies (39) and many more products for this protein. A total of 51 LLGL2 products are currently listed.
9130006H11Rik, cb521, HGL, Lgl-2, LGL2, Llglh2, RGD1560307, sb:cb521, wu:fc06g08, wu:fl37c09, zgc:55895
list all proteins Gene Name GeneID UniProt
LLGL2 3993 Q6P1M3
LLGL2 217325 Q3TJ91
Rat LLGL2 LLGL2 360661  

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LLGL2 Proteins (LLGL2) by Origin

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More Proteins for LLGL2 Interaction Partners

Zebrafish Lethal Giant Larvae Homolog 2 (Drosophila) (LLGL2) interaction partners

  1. New roles and interactions for Lgl2 that are crucial for both lumenogenesis and ciliogenesis and indicate that these processes are genetically separable in zebrafish.

  2. lgl2 is necessary for hemidesmosome formation and maintenance of the tissue integrity in the developing basal epidermis

  3. Lgl2 and E-cadherin (show CDH1 Proteins) act antagonistically to control the localisation of integrin alpha 6 (show ITGA6 Proteins) during the formation of hemidesmosomes in the developing epidermis

Human Lethal Giant Larvae Homolog 2 (Drosophila) (LLGL2) interaction partners

  1. The crystal structures of the Dlg4 (show DLG4 Proteins) GK domain in complex with two phosphor-Lgl2 peptides reveal the molecular mechanism underlying the specific and phosphorylation-dependent Dlg (show DLG4 Proteins)/Lgl complex formation.

  2. Loss or aberrant Lgl2 staining was useful in identifying Barrett gastric foveolar dysplasia

  3. Hugl (show LLGL1 Proteins)-2 induces MET and suppresses Snail (show SNAI1 Proteins) tumorigenesis.

  4. Hugl1 (show LLGL1 Proteins) and Hugl2 play an essential role in the maintenance of breast epithelial polarity and differentiated cell morphology, as well as growth control.

  5. There is a role of Lgl2 immunohistochemistry as an adjunct in the diagnosis of foveolar-type gastric dysplasia.

  6. Lgl2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias.

  7. binding between Lgl2 and LGN (show GPSM2 Proteins) play a role in mitotic spindle organization through regulating formation of the LGN.NuMA complex; Lgl2 forms a Lgl2.Par-6 (show PARD6A Proteins).aPKC.LGN complex, which responds to mitotic signaling to establish normal cell division

  8. The identification and functional characterization of the promoter region ( approximately 1.2kb) of the Hugl (show LLGL1 Proteins)-2 gene are reported.

  9. Retention of Lgl2 expression is critical for the epithelial phenotype;its loss might be involved in metastasis.

  10. We propose that Lgl2 may be a potential marker to rule out gastric epithelial dysplasia and adenocarcinoma in diagnostic specimens.

Mouse (Murine) Lethal Giant Larvae Homolog 2 (Drosophila) (LLGL2) interaction partners

  1. Data suggest that mammalian Llgl2 is required for proper polarized invasion of trophoblasts and efficient branching morphogenesis during placental development, but, unlike its Drosophila ortholog, it does not function as a canonical tumor suppressor gene.

LLGL2 Protein Profile

Protein Summary

The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with LLGL2

  • lethal giant larvae homolog 2 (llgl2)
  • lethal giant larvae homolog 2 (Drosophila) (llgl2)
  • lethal giant larvae homolog 2 (Drosophila) (LLGL2)
  • lethal giant larvae homolog 2 (Drosophila) (Llgl2)
  • 9130006H11Rik protein
  • cb521 protein
  • HGL protein
  • Lgl-2 protein
  • LGL2 protein
  • Llglh2 protein
  • RGD1560307 protein
  • sb:cb521 protein
  • wu:fc06g08 protein
  • wu:fl37c09 protein
  • zgc:55895 protein

Protein level used designations for LLGL2

lethal giant larvae 2 , lethal giant larva 2 , lethal(2) giant larvae protein homolog 2 , pen , penner , protein penner , human giant larvae homolog , lethal giant larvae-like protein 2

447703 Xenopus laevis
548396 Xenopus (Silurana) tropicalis
795670 Danio rerio
3993 Homo sapiens
217325 Mus musculus
100174337 Pongo abelii
539545 Bos taurus
360661 Rattus norvegicus
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