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Unpredictable chronic mild stress mice exhibited lower nucleus accumbens (NAC) shell levels of phospholipase Cbeta.
Heightened PLCbeta1b activity observed in diseased myocardium contributes to pathology by PKCalpha (show PKCa Proteins)-mediated contractile dysfunction.
inhibition of miR (show MLXIP Proteins)-214 in C2C12 cells significantly enhances the protein level of PLCbeta1 and promotes C2C12 BMP-2 (show BMP2 Proteins)-induced osteogenesis by targeting PLCbeta1
Results indicate that PLC (show HSPG2 Proteins)-beta1 signalling in the medial prefrontal cortex is required for working memory
In pro-B-lymphoblastic cells (Ba/F3), treated with H2O2, PI-PLCbeta1b conferred resistance to cell death, promoting cell cycle progression and cell proliferation and influencing the expression of cyclin A (show CCNA2 Proteins) and E.
Tnis study demonistrated that plc (show HSPG2 Proteins) beta1 distribuate in mice cerebellum.
Galphaq (show GNAQ Proteins)-coupled Lpar1 (show LPAR1 Proteins) regulates cell proliferation and migration by activating two distinct PLC (show HSPG2 Proteins)-beta isozymes, PLC (show HSPG2 Proteins)-beta1 and PLC (show HSPG2 Proteins)-beta2, respectively.
These findings highlight a novel pathway by which nuclear PLCs affect insulin (show INS Proteins) secretion and identify PPARgamma (show PPARG Proteins) as a novel molecular target of nuclear PLCs.
Demonstrate critical role of the glutamatergic system in the phenotype of the PLC (show HSPG2 Proteins)-beta1 knockout mouse and highlight the role of these interconnected signalling pathways in schizophrenia-like behavioural disruption.
Regulation of nuclear phospholipase C (show PLC Proteins), beta 1 (review)
Polymorphism of the PLCB4/B1 genes might be involved in the coronary artery aneurysm pathogenesis of Kawasaki disease.
Reduction in plasma membrane PI(4,5)P2 abundance by PTPRN2 and PLCbeta1 releases the PI(4,5)P2-binding protein cofilin from its inactive membrane-associated state into the cytoplasm where it mediates actin turnover dynamics.
The rs6108160 polymorphism in the PLCB1 gene reached statistical significance after antidepressant drug use.
results show that PI-PLCbeta1 quantification in MDS (show PAFAH1B1 Proteins) predicts the response to azacitidine and is associated with an increased myeloid differentiation.
one specific Egr-1 (show EGR1 Proteins) binding site was identified at nt-451/-419 and PLCB1 promoter activity was increased more than 5-fold
Cholesterol regulates HERG (show KCNH2 Proteins) K+ channel (show KCNC4 Proteins) activation by increasing phospholipase C beta1 expression
Our data indicate that the amplification of PLCb1a expression, following treatment with kinamycin F, confers a real advantage to K562 cells viability and protects cells themselves from apoptosis.
PLCB1 is now reported in a number of different EIEE (early infantile epileptic encephalopathy) phenotypes and our report provides further evidence for phenotypic pleiotropy encountered in early infantile epilepsy syndromes.
Novel variations in PLCB1 do not allow prediction of functional phenotypes that might explain, at least in part, the symptoms of malignant migrating partial seizures of infancy (MMPSI).
PLC (show HSPG2 Proteins)-beta1 and DAGL-alpha (show DAGLA Proteins) are detected in discrete brain regions, with a marked predominance of pyramidal morphologies of positive cortical cells.[review]
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.
phosphoinositide-specific phospholipase C beta 1
, phospholipase C, beta 1 (phosphoinositide-specific)
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1-like
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
, phosphoinositide phospholipase C
, phosphoinositide phospholipase C-beta-1
, phospholipase C-beta-1
, phospholipase C-beta-1a
, monophosphatidylinositol phosphodiesterase
, phosphoinositidase C
, phospholipase C-I
, triphosphoinositide phosphodiesterase
, Phospholipase C-beta1