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apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (show CDK2 Proteins), leading to shortening of G1 and S phases
Neural induction by Syn4 (show SNTG1 Proteins) through the PKC pathway requires inhibition of PKCdelta (show PKCd Proteins) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC of the KCNE1 (show KCNE1 Proteins) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C in Kv4.3 (show KCND3 Proteins)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.
we suggest that PKCA tightly controls TRM6/61 activity to prevent translation deregulation that would favor neoplastic development.
Prolonged membrane association/activation of PKCalpha is seen in self-renewing epithelium of the intestine, cervix, and skin.
RNA sequencing identified a novel ATPase, Ca2 (show CA2 Proteins)+ transporting, plasma membrane 4(ATP2B4 (show ATP2B4 Proteins))-protein kinase C-alpha (PRKCA) fusion transcript.
InB may exhibit growth-inhibitory activity through the activation of PKCalpha, followed by an increase in NFAT (show NFATC1 Proteins) transactivation ability.
High P-PKCalpha expression in neoplastic gastric cancer biopsy samples as compared to nonneoplastic samples suggests that P-PKCalpha might act as an indicator of gastric cancer progression.
Data show that bisindolylmaleimides (BIMs) Ro 31-8220 also blocks activity of the solute carrier organic cation transporter 1 (OCT1), involved in uptake of marketed drugs in the liver, in a protein kinase C (PKC)-independent manner.
this study identified PKC (show PRRT2 Proteins) as the kinase that phosphorylates a specific site in the linker region of PACSIN2 (show PACSIN2 Proteins).
results indicate that PKC (show PRRT2 Proteins)-mediated cortactin (show CTTN Proteins) phosphorylation might be implicated in the maintenance of growth cone
This study showed that SLC44A1 (show SLC44A1 Proteins)-PRKCA fusion seems to be a specific characteristic of Papillary glioneuronal tumors with a high diagnostic value.
Syndecan-4 is essential for transmitting the mechanotransduction signals via activation of PKC-alpha and is important for tumor cells spreading, assembly of actin cytoskeleton and cell contractility.
We conclude that melatonin, via modulation of PKC and Ca(2 (show CA2 Proteins)+) signaling, could potentially stimulate the Nrf2 (show NFE2L2 Proteins)-mediated antioxidant response in mouse pancreatic acinar cells.
PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2, possibly via increased pulmonary arterial TP receptor expression.
at the functionally mature calyx of Held synapse the Ca(2+)-dependent protein kinase C isoforms alpha and beta are necessary for post-tetanic potentiation, a form of plasticity thought to underlie short-term memory
PKC gene deletion is responsible for hair loss.
The overall result suggests the cancer preventive activity of quercetin via the induction of apoptosis and modulates PKC signaling with the reduction of oxidative stress in ascite cells of lymphoma-bearing mice.
the ANG II (show AGT Proteins)-dependent upregulation of renin (show REN Proteins) in the collecting duct depends on PKC-alpha, which allows the augmentation of cAMP production and activation of PKA/CREB (show CREB1 Proteins) pathway
role for PKCalpha in the regulation of ECM (show MMRN1 Proteins) structure and deposition during skin wound healing.
A dynamic PKC phosphorylation/de-phosphorylation cycle of Munc18-1 (show STXBP1 Proteins) drives short-term enhancement of transmitter release during post-tetanic potentiation.
PKC-alpha and -delta have been shown to play crucial role in cardiac adaptation during physiological and pathological hypertrophy respectively thereby rendering compromised cardiac function to an otherwise efficient heart by conditional reversal of activation.
Data show increased expression of T-type Ca(2 (show CA2 Proteins)+) current and association of protein kinase C alpha (PKCalpha) with caveolin-3 (Cav-3 (show CAV3 Proteins))was disrupted in the hypertrophic ventricular myocyte.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (show CA2 Proteins)+-sensitivity, structure and kinetics are brought about through PKC phosphorylation of cardiac troponin T (show TNNT2 Proteins).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Proteins) expression by NF-kappaB (show NFKB1 Proteins)-MT1-MMP (show MMP14 Proteins)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (show ASS1 Proteins) Ser (show SIGLEC1 Proteins)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (show TUBB Proteins).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (show CDK7 Proteins) Calpha (show PRKACA Proteins)
By regulating VEGFR2 (show KDR Proteins) expression and activation, PKC-epsilon (show PRKCE Proteins) expression is critical for activation of Akt (show AKT1 Proteins) and eNOS (show NOS3 Proteins) by VEGF (show VEGFA Proteins) and contributes to VEGF (show VEGFA Proteins)-stimulated Erk (show MAPK1 Proteins) activation, whereas PKC-alpha has opposite effects.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (show CA2 Proteins)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (show PPP1R14A Proteins) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (show ESR1 Proteins).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha