Browse our PYGO2 Proteins (PYGO2)

Full name:
Pygopus Homolog 2 (Drosophila) Proteins (PYGO2)
On are 4 Pygopus Homolog 2 (Drosophila) (PYGO2) Proteins from 3 different suppliers available. Additionally we are shipping PYGO2 Antibodies (26) and many more products for this protein. A total of 33 PYGO2 products are currently listed.
1190004M21Rik, mpygo2, RGD1308535
list all proteins Gene Name GeneID UniProt
Mouse PYGO2 PYGO2 68911  
Rat PYGO2 PYGO2 295251  
PYGO2 90780 Q9BRQ0

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PYGO2 Proteins (PYGO2) by Origin

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More Proteins for PYGO2 Interaction Partners

Mouse (Murine) Pygopus Homolog 2 (Drosophila) (PYGO2) interaction partners

  1. It analyzed Wnt1 (show WNT1 Proteins)-cre(+/-)::Pygo2(-/-) mice in which the beta-catenin (show CTNNB1 Proteins) co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells.

  2. These findings identify Pygo2 as an important regulator of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) function in skin epithelia and p53 (show TP53 Proteins) activation as a prominent downstream event of beta-catenin (show CTNNB1 Proteins)/Pygo2 action in stem cell activation.

  3. these results suggest that Pygo2 acts at a step downstream of mammary stem cell accumulation to facilitate transformation, and that it regulates the tumor initiating capacity and lineage preference of the already transformed mammary cells, in MMTV-Wnt1 (show WNT1 Proteins) mice.

  4. even in the absence of the potentially redundant Pygo1 (show PYGO1 Proteins), Pygo2 does not require the H3K4me2/3 binding activity to sustain its function during mouse development

  5. Mouse pygo2 expression was detected in the developing epidermis and hair follicles, which suggests that mpygo2 might mediate the effect of this signaling pathway in mouse skin.

  6. In mammals, the Pygo1 (show PYGO1 Proteins)/Pygo2 genes are not absolutely required for canonical Wnt (show WNT2 Proteins) signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt (show WNT2 Proteins) signal intensity

  7. Pygo2 can function in the Wnt (show WNT2 Proteins) pathway, but its activity in lens development is Wnt (show WNT2 Proteins) pathway-independent

  8. ablation of pygo2 expression causes defects in morphogenesis of both ectodermally and endodermally derived tissues, including brain, eyes, hair follicles, and lung

  9. Study finds canonical Wnt (show WNT2 Proteins) signaling to be predominantly active in the mesenchyme at the time when mPygo2 is required and demonstrate the dependence of Wnt (show WNT2 Proteins) signal transduction on mPygo2.

  10. Pygo2 is involved in the chromatin remodeling events that lead to nuclear compaction of male germ cells

Human Pygopus Homolog 2 (Drosophila) (PYGO2) interaction partners

  1. Findings are consistent with a model in which acetylation of Pygo2 by CBP/p300 (show CREBBP Proteins) family members in the active TCF (show HNF4A Proteins)/beta-catenin (show CTNNB1 Proteins) complex occurs coincident with histone acetylation and may be required for the recycling of Pygo2 away from the complex subsequent to target gene activation.

  2. The activation of its expression by ERalpha (show ESR1 Proteins) and/or specificity protein-1 (SP1 (show SP1 Proteins)) suggests hPYGO2 as a theranostic target for hormone therapy responsive and refractory breast cancer.

  3. Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.

  4. this study demonstrated that SNPs in the coding region of Pygo2 might be one of the causative factors in idiopathic oligospermia and azoospermia, resulting in male infertility.

  5. Our findings suggest that Pygopus-2 may be an important predictor of poor outcome in HCC (show FAM126A Proteins) patients, and could serve as a novel biomarker for HCC (show FAM126A Proteins).

  6. Pygopus-2 over-expression is associated with hepatic carcinoma.

  7. Pygo2 is a common node downstream of oncogenic Wnt (show WNT2 Proteins) and Akt (show AKT1 Proteins) signaling pathways.

  8. We conclude that abnormal Pygo2 protein expression may be a marker for advanced non-small cell lung cancer

  9. PYGO2 is identified as a new molecular marker of invasive tumors in esophageal squamous cell carcinoma.

  10. SNPs in the coding region of Pygo2 gene may be one of the causative factors in idiopathic oligospermia and azoospermia, resulting in male infertility.

PYGO2 Protein Profile

Protein Summary

Involved in signal transduction through the Wnt pathway.

Alternative names and synonyms associated with PYGO2

  • pygopus 2 (Pygo2)
  • pygopus homolog 2 (Drosophila) (PYGO2)
  • 1190004M21Rik protein
  • mpygo2 protein
  • RGD1308535 protein

Protein level used designations for PYGO2

pygopus homolog 2 , pygopus 2

68911 Mus musculus
295251 Rattus norvegicus
90780 Homo sapiens
490440 Canis lupus familiaris
540401 Bos taurus
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