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HOTAIR is regulated by the RhoC-MRTF-A-SRF signaling pathway in breast cancer cells.
E2F transcription factor 1 (E2F1 (show E2F1 Proteins)) downregulated micrRNA miR (show MLXIP Proteins)-519d directly and miR (show MLXIP Proteins)-519d downregulated Ras homolog gene family member C (RhoC) directly.
These results reveal a previously unidentified pathway downstream of RHO that regulates the polarity of migrating cells through Golgi reorientation in a FAM65A-, CCM3 (show PDCD10 Proteins)- and MST3 (show STK24 Proteins)- and MST4 (show MST4 Proteins)-dependent manner.
During the process of epithelial-mesenchymal transition in A549 cells induced by TGF-beta1 (show TGFB1 Proteins), upregulated RhoC protein and RhoC activity were detected, which was associated with the enhanced invasive capability of the cells in vitro.
RhoC downregulation may inhibit the proliferation, drug resistance, invasion and migration of ovarian cancer stem cells.
Downregulation of RHOC inhibited cholangiocellular carcinoma cells invasion and migration partially via inhibition of matrix metalloproteinase 2 (show MMP2 Proteins), 3 and 9 expression. RHOC also modulated the expression of several epithelial-mesenchymal transition (EMT (show ITK Proteins))-associated proteins
RT-PCR and Western blot assays demonstrated that miR (show MLXIP Proteins)-372 transfection reduced the expression of RhoC.
Significant associations between ROCK1 (show ROCK1 Proteins), ROCK2 (show ROCK2 Proteins), RhoA (show RHOA Proteins) and RhoC gene polymorphisms and systemic sclerosis were demonstrated.
study has identified several new proteins like RHOC, DLG5 (show DLG5 Proteins), UGDH (show UGDH Proteins), TMOD3 (show TMOD3 Proteins) in addition to known chemoresistance associated proteins in non-small cell lung carcinoma.
the oncogene (show RAB1A Proteins) RhoC, a driver of metastatic potential, modulates glutamine (show GFPT1 Proteins) and N-acetylaspartate metabolism in Inflammatory Breast Cancer cells in vitro, revealing a novel role for RhoC as a regulator of tumor cell metabolism that extends beyond its well known role in cytoskeletal rearrangement.
RhoC co-localizes with Fam65b (show FAM65B Proteins) in stereocilia and regulates Fam65b (show FAM65B Proteins) oligomerization what is critical for hair cell function.
Inhibition of ovarian epithelial carcinoma tumorigenesis and progression by miR106b proceeds through the RhoC pathway.
RHOC and RAB38 (show RAB38 Proteins) are dispensable for osteoclast function.
A p27(kip1 (show CDKN1B Proteins))-binding protein, p27RF-Rho (show LAMTOR1 Proteins), promotes cancer metastasis via activation of RhoA (show RHOA Proteins) and RhoC.
We found that both RhoA and RhoC, but not RhoB, were required for initiation of centrosome duplication, and overactivation of RhoA, as well as RhoC, but not RhoB, promoted centrosome duplication and centrosome amplification.
RhoC has a role in metastasis of lung cancer in mice
loss of RhoC does not affect tumor development but decreases tumor cell motility and metastatic cell survival leading to a drastic inhibition of metastasis
RhoC promotes melanoma progression via separate mechanisms that regulate the PI3K/Akt (show AKT1 Proteins) pathway and the ROCK signaling pathway.
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
ras homolog gene family, member C
, rho-related GTP-binding protein RhoC
, RAS-related homolog 9
, oncogene RHO H9
, rho cDNA clone 9
, rhoC GTPase
, small GTP binding protein RhoC
, aplysia ras-related homolog 9 (RhoC)
, ras homolog 9 (RhoC)
, silica-induced gene 61 protein
, GTP-binding protein
, GTPase cRhoC