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Human SFRP1 ELISA Kit for Sandwich ELISA - ABIN421484
Taylan, Sari, Akinci, Bilge, Kozaci, Akar, Colak, Yalcin, Gunay, Akkoc: Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of patients with ankylosing spondylitis. in BMC musculoskeletal disorders 2012
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SFRP1 downregulation may result from epigenetic silencing and is associated with worse survival in nasopharyngeal carcinoma
in gliomas there was correlation of SFRP1 methylation with tumor grade and patients' survival
Hepatocellular carcinoma patients with high SFRP1 expression in tumor tissue had a significantly better overall survival rate.
Reduced SFRP1 expression is associated with acute myeloid leukemia (show BCL11A ELISA Kits).
Hypermethylation of the selected markers (MAL (show MAL ELISA Kits), PRIMA1 (show PRIMA1 ELISA Kits), PTGDR (show PTGDR ELISA Kits) and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer.
SFRP1 is a direct target of MiR (show MLXIP ELISA Kits)-27a in the regulation of glioma invasion and cell migration.
In human mammary epithelial cells with either SFRP1 knocked down (TERT-siSFRP1) and rescued SFRP1 expression ( (show PGR ELISA Kits)MCF7-SFRP1), estrogen signaling is augmented.
The increased placental expression of sFRP1 seen in smokers impairs fetal growth by inhibiting WNT (show WNT2 ELISA Kits) signaling and trophoblast proliferation.
miR (show MLXIP ELISA Kits)-27a induced gene silencing contributes to bone metabolism in hFOB cells in vitro, which is partly affected by the post-transcriptional regulation of sFRP1, during osteoblast proliferation, apoptosis and differentiation.
While SFRP1 re-expression generally mediated distinct patterns of transcriptionally induced or repressed genes in BT20 and SKBR3 cells, BDNF (show BDNF ELISA Kits) was a SFRP1-induced gene in both cell lines.
OVOL1 (show OVOL1 ELISA Kits)-regulated Fst (show FST ELISA Kits) and SFRP1 affect hair inductive potency of neonatal dermal cells.
Down stream actions of estrogen-mediated signaling, including cellular proliferation and progesterone receptor (show PGR ELISA Kits) transcription, are elevated in estradiol treated explant cultures derived from Sfrp1(-/-) mice.
Study suggests that the induction of the WNT (show WNT2 ELISA Kits) pathway is a potentially crucial pathway in the development of cardiomyopathy with aging with sFRP-1 being a critical factor in maintaining normal cardiovascular structure and function during this process.
the expression of Sfrp1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity
findings suggest that SFRP1 expression in the adult maintains progenitor cells within their undifferentiated state and suggests that manipulation of this pathway is a potential target to augment the lung repair process during disease
Sfrp1 is required for inhibition of renal damage through the non-canonical Wnt (show WNT2 ELISA Kits)/PCP (show BMP1 ELISA Kits) pathway in a mouse model of obstructive nephropathy
SFRP1 deficiency in mice results in the development of diet-induced obesity aggravated by inflammation and breast cancer.
Sfrp1(-/-) mice have less DNA fragmentation, whilst caspase-3 (show CASP3 ELISA Kits) expression is decreased, and that p53 (show TP53 ELISA Kits) expression is generally diminished.
secreted FRP1 either inhibits or enhances signaling in the Wnt3a (show WNT3A ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathway
Sfrp1 and Sfrp2 (show SFRP2 ELISA Kits) appear to have a positive regulatory function because Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling in lens epithelial cells was reduced in Sfrp1 and Sfrp2 (show SFRP2 ELISA Kits) DKO mice
Results show the expression level of SFRP1 significantly higher in the embryonic skeletal muscle and diminishes after, whereas miR-206/1 show the inverse. Also, SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development.
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling\; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
secreted frizzled-related protein 1
, Secreted frizzled-related protein 1
, secreted apoptosis-related protein 2
, secreted frizzled related protein 1
, frizzled in aorta protein
, frzA protein
, secreted frizzled-related sequence protein 1