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Browse our anti-TCF7L2 (TCF7L2) Antibodies

Full name:
anti-Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) Antibodies (TCF7L2)
On are 90 Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) Antibodies from 17 different suppliers available. Additionally we are shipping TCF7L2 Proteins (4) and TCF7L2 Kits (3) and many more products for this protein. A total of 104 TCF7L2 products are currently listed.
mTcf-4B, mTcf-4E, TCF-4, TCF4, TCF4B, tcf4e, TCFL2, XTCF-4
list all antibodies Gene Name GeneID UniProt
TCF7L2 21416 Q924A0
TCF7L2 6934 Q9NQB0
TCF7L2 679869  

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Most Popular Reactivities for anti-TCF7L2 (TCF7L2) Antibodies

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anti-Mouse (Murine) TCF7L2 Antibodies:

anti-Human TCF7L2 Antibodies:

anti-Rat (Rattus) TCF7L2 Antibodies:

All available anti-TCF7L2 Antibodies

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Top referenced anti-TCF7L2 Antibodies

  1. Human Monoclonal TCF7L2 Primary Antibody for IF, WB - ABIN394207 : Heni, Ketterer, Thamer, Herzberg-Schäfer, Guthoff, Stefan, Machicao, Staiger, Fritsche, Häring: Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. in Diabetes 2010 (PubMed)
    Show all 5 references for ABIN394207

  2. Human Polyclonal TCF7L2 Primary Antibody for EIA, WB - ABIN955128 : Hansson, Zhou, Renström, Osmark: Molecular function of TCF7L2: Consequences of TCF7L2 splicing for molecular function and risk for type 2 diabetes. in Current diabetes reports 2010 (PubMed)
    Show all 2 references for ABIN955128

  3. Human Monoclonal TCF7L2 Primary Antibody for IHC (p), ELISA - ABIN520776 : da Silva Xavier, Loder, McDonald, Tarasov, Carzaniga, Kronenberger, Barg, Rutter: TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. in Diabetes 2009 (PubMed)
    Show all 2 references for ABIN520776

  4. Cow (Bovine) Polyclonal TCF7L2 Primary Antibody for WB - ABIN2777926 : Ren, Han, Wang, Zhang, Han, Luo, Zhou, Ji: Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population. in Diabetologia 2008 (PubMed)

More Antibodies against TCF7L2 Interaction Partners

Mouse (Murine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Kaiso (show ZBTB33 Antibodies) and Sox10 (show SOX10 Antibodies) sequentially interact with Tcf7l2 to coordinate the maturation of oligodendrocyte.

  2. Tcf7l2 plays a cell autonomous role in the control of beta cell function and mass, serving as an important regulator of gene expression and islet cell coordination

  3. Tcf7l2 is regulating proinsulin (show INS Antibodies) expression directly via Isl1 (show ISL1 Antibodies), Ins1 and indirectly via MafA (show MAFA Antibodies), NeuroD1 (show NEUROD1 Antibodies) and Pdx1 (show PDX1 Antibodies).

  4. Transcription factor 7-like 2 positively regulates neonatal and postnatal mouse oligodendrocyte differentiation during developmental myelination and remyelination in a manner independent of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.

  5. TCF7L2 expressed in the pancreatic beta cells plays a crucial role in glucose metabolism through regulation of the beta cell mass.

  6. Marked expression of TCF7L2 in oligodendrocytes is restricted to a well defined time period during developmental myelination in human and mouse central nervous system tissue samples.

  7. 5-FU acutely induces the severe myelin degeneration in adolescence and disruption of TCF7L2/HDAC1/HDAC2 (show HDAC1 Antibodies) complex is at least partially involved in 5-FU-induced demyelination.

  8. Knockdown of TCF7L2 blocked the malondialdehyde-induced glucose-stimulated insulin (show INS Antibodies) secretion elevation.

  9. This is the first report to show that DIF-1 inhibits tumor growth in vivo, consistent with its in-vitro action, suggesting that this compound may have potential as a novel anti-tumor agent.

  10. The dominant-negative isoforms of TCF7L2 are predominant in the embryonic thalamus but disappear postnatally.

Zebrafish Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries.

  2. Dorsal and ventral habenulae develop in different regions of prosomere 2. In the process of ventral habenula formation, functional tcf7l2 gene activity is required and in its absence, ventral habenular neurons do not develop.

  3. In embryos, the tcf4 gene is highly regulated at the level of RNA splicing such that the variant proteins that are produced contain or lack domains proposed to be essential in repression or activation of transcription.

  4. Study underscores the involvement of Tcf4 in maintaining proliferative self-renewal in the intestine throughout life.

  5. This study reveals that Tcf4 (tcf7l2) is the major effector of Wnt (show WNT2 Antibodies) signaling in the intestine during zebrafish organogenesis.

Xenopus laevis Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. XTcf4 has no repressive role but is required to activate expression of Xnr3 and chordin (show CHRD Antibodies) in organizer cells at the gastrula stage

  2. regulation of XTcf-4 by canonical wnt (show WNT2 Antibodies)-signaling is directly controlled by binding to and activating a consensus Lef/Tcf (show HNF4A Antibodies) binding site within its own promoter

Human Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Data indicate that triglycerides were significantly associated with the T risk allele of the transcription factor 7-like 2 (TCF7L2) gene.

  2. Transcription factor 7-like 2 (TCF7L2) gene encodes the TCF-4 (show TCF4 Antibodies) transcription factor, which forms a part of the Wnt (show WNT2 Antibodies) signaling pathway.

  3. The T allele of TCF7L2 rs7903146 polymorphism was associated with susceptibility of gestational diabetes mellitus in overall population in white, Hispanic/Latino and Asian sub-groups. Meta-analysis.

  4. Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (show ADCY5 Antibodies), ADRA2A (show ADRA2A Antibodies), CDKAL1 (show CDKAL1 Antibodies), CDKN2A (show CDKN2A Antibodies)/B, GRB10 (show GRB10 Antibodies), and TCF7L2

  5. The T-allele frequencies of TCF7L2 polymorphisms rs12255372 and rs7903146 were 30% (26-35%), 32% (27-37%) and 29% (25-34%), 36% (31-41%), respectively.

  6. Despite limited sample size, the study indicates that rs7903146-T allele in TCF7L2 was associated with higher mean nocturnal glucose dependent on body composition, which might suggest that rs7902146 affects liver-specific aspects of glucose metabolism.

  7. TCF7L2 rs10885409 C allele is a T2DM risk factor in Emiratis; this association is modulated by obesity status, but the Pro12Ala mutation in PPAR-gamma2 (show PPARG Antibodies) is not associated with T2DM risk in this population

  8. rs12255372 and rs4506565 variants(but not rs7903146) of TCF7L2 show an association with type 2 diabetes mellitus for the Saudi population of the Eastern Province of Saudi Arabia

  9. the TCF7L2 rs12255372 (G>T) polymorphism might be one of the most important genetic factors associated with T2DM susceptibility.

  10. A genetic variant harbored within the TCF7L2 locus rs7903146 impairs glucose tolerance through effects on glucagon (show GCG Antibodies) as well as on insulin (show INS Antibodies) secretion.

Cow (Bovine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. findings report an independent confirmation of the association of the TCF7L2 (show TCF4 Antibodies) gene with milk yield and composition traits.

Pig (Porcine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Genes implied in human type 2 diabetes development, TCF7L2, WFS1 (show WFS1 Antibodies), FTO (show FTO Antibodies), SLC30A8 (show SLC30A8 Antibodies), and GCKR (show GCKR Antibodies), were mapped on Sus scrofa chromosomes 14, 8, 6, 4, and 3, respectively. Only TCF7L2 was significantly associated with five fat traits in pigs.

TCF7L2 Antigen Profile

Antigen Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.

Alternative names and synonyms associated with TCF7L2

  • transcription factor 7-like 2 (T-cell specific, HMG-box) (LOC100229459) antibody
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2) antibody
  • transcription factor 7 like 2, T cell specific, HMG box (Tcf7l2) antibody
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (tcf7l2) antibody
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (Tcf7l2) antibody
  • mTcf-4B antibody
  • mTcf-4E antibody
  • TCF-4 antibody
  • TCF4 antibody
  • TCF4B antibody
  • tcf4e antibody
  • TCFL2 antibody
  • XTCF-4 antibody

Protein level used designations for TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box) , HMG box transcription factor 4 , T-cell factor 4 , T-cell-specific transcription factor 4 , mTCF-4 , transcription factor 7-like 2 , transcription factor 7-like 2, T-cell specific, HMG-box , transcription factor tcf4 , T-cell factor XTCF-4A , transcription factor Tcf4 , T-cell factor-4 variant A , T-cell factor-4 variant B , T-cell factor-4 variant C , T-cell factor-4 variant D , T-cell factor-4 variant E , T-cell factor-4 variant F , T-cell factor-4 variant G , T-cell factor-4 variant H , T-cell factor-4 variant I , T-cell factor-4 variant J , T-cell factor-4 variant K , T-cell factor-4 variant L , T-cell factor-4 variant M , T-cell factor-4 variant X2 , hTCF-4

100229459 Taeniopygia guttata
100545943 Meleagris gallopavo
21416 Mus musculus
30510 Danio rerio
399164 Xenopus laevis
395508 Gallus gallus
6934 Homo sapiens
540481 Bos taurus
679869 Rattus norvegicus
100153922 Sus scrofa
486894 Canis lupus familiaris
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