Browse our anti-TCF7L2 (TCF7L2) Antibodies

Full name:
anti-Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) Antibodies (TCF7L2)
On www.antibodies-online.com are 103 Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) Antibodies from 17 different suppliers available. Additionally we are shipping TCF7L2 Kits (5) and TCF7L2 Proteins (4) and many more products for this protein. A total of 119 TCF7L2 products are currently listed.
Synonyms:
mTcf-4B, mTcf-4E, TCF-4, TCF4, TCF4B, tcf4e, TCFL2, XTCF-4
list all antibodies Gene Name GeneID UniProt
TCF7L2 21416 Q924A0
TCF7L2 6934 Q9NQB0
TCF7L2 679869  

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Most Popular Reactivities for anti-TCF7L2 (TCF7L2) Antibodies

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anti-Mouse (Murine) TCF7L2 Antibodies:

anti-Human TCF7L2 Antibodies:

anti-Rat (Rattus) TCF7L2 Antibodies:

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Top referenced anti-TCF7L2 Antibodies

  1. Human Monoclonal TCF7L2 Primary Antibody for IF, WB - ABIN394207 : Heni, Ketterer, Thamer, Herzberg-Schäfer, Guthoff, Stefan, Machicao, Staiger, Fritsche, Häring: Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. in Diabetes 2010 (PubMed)
    Show all 5 references for 394207

  2. Human Polyclonal TCF7L2 Primary Antibody for EIA, WB - ABIN955128 : Hansson, Zhou, Renström, Osmark: Molecular function of TCF7L2: Consequences of TCF7L2 splicing for molecular function and risk for type 2 diabetes. in Current diabetes reports 2010 (PubMed)
    Show all 2 references for 955128

  3. Human Monoclonal TCF7L2 Primary Antibody for IHC (p), ELISA - ABIN520776 : da Silva Xavier, Loder, McDonald, Tarasov, Carzaniga, Kronenberger, Barg, Rutter: TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. in Diabetes 2009 (PubMed)
    Show all 2 references for 520776

  4. Cow (Bovine) Polyclonal TCF7L2 Primary Antibody for WB - ABIN2777926 : Ren, Han, Wang, Zhang, Han, Luo, Zhou, Ji: Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population. in Diabetologia 2008 (PubMed)

More Antibodies against TCF7L2 Interaction Partners

Mouse (Murine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. TCF7L2 mediates canonic Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling and c-Myc (show MYC Antibodies) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) to c-Myc (show MYC Antibodies) axis can be explored for preventing and treating heart failure.

  2. These findings suggest a unique role for Tcf7l2 in generating distinct neuronal phenotypes from homogeneous progenitor population.

  3. Tcf7l2 may be involved in maintenance of stem/progenitor cells properties.

  4. results indicate that miR (show MLXIP Antibodies)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) and Wnt (show WNT2 Antibodies) signaling pathway by directly targeting Smad7 (show SMAD7 Antibodies) and Tcf7l2

  5. Tcf7l2 protein levels decline upon initiation of endocrine differentiation in vivo, disclosing the downregulation of this factor in the developing endocrine compartment.

  6. Kaiso (show ZBTB33 Antibodies) and Sox10 (show SOX10 Antibodies) sequentially interact with Tcf7l2 to coordinate the maturation of oligodendrocyte.

  7. Tcf7l2 plays a cell autonomous role in the control of beta cell function and mass, serving as an important regulator of gene expression and islet cell coordination

  8. Tcf7l2 is regulating proinsulin (show INS Antibodies) expression directly via Isl1 (show ISL1 Antibodies), Ins1 and indirectly via MafA (show MAFA Antibodies), NeuroD1 (show NEUROD1 Antibodies) and Pdx1 (show PDX1 Antibodies).

  9. Transcription factor 7-like 2 positively regulates neonatal and postnatal mouse oligodendrocyte differentiation during developmental myelination and remyelination in a manner independent of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.

  10. TCF7L2 expressed in the pancreatic beta cells plays a crucial role in glucose metabolism through regulation of the beta cell mass.

Zebrafish Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries.

  2. Dorsal and ventral habenulae develop in different regions of prosomere 2. In the process of ventral habenula formation, functional tcf7l2 gene activity is required and in its absence, ventral habenular neurons do not develop.

  3. In embryos, the tcf4 gene is highly regulated at the level of RNA splicing such that the variant proteins that are produced contain or lack domains proposed to be essential in repression or activation of transcription.

  4. Study underscores the involvement of Tcf4 in maintaining proliferative self-renewal in the intestine throughout life.

  5. This study reveals that Tcf4 (tcf7l2) is the major effector of Wnt (show WNT2 Antibodies) signaling in the intestine during zebrafish organogenesis.

Xenopus laevis Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. XTcf4 has no repressive role but is required to activate expression of Xnr3 and chordin (show CHRD Antibodies) in organizer cells at the gastrula stage

  2. regulation of XTcf-4 by canonical wnt (show WNT2 Antibodies)-signaling is directly controlled by binding to and activating a consensus Lef/Tcf (show HNF4A Antibodies) binding site within its own promoter

Human Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. we show that TopoIIalpha forms protein-protein interactions with beta-catentin and TCF4 (show TCF4 Antibodies) and interacts with Wnt (show WNT2 Antibodies) response elements (WREs) and promoters of direct target genes of TCF (show HNF4A Antibodies) transcription, including: MYC (show MYC Antibodies), vimentin (show VIM Antibodies), AXIN2 (show AXIN2 Antibodies) and LEF1 (show LEF1 Antibodies)

  2. novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women

  3. GWAS identified two known loci (TCF7L2 and KCNQ1 (show KCNQ1 Antibodies)) reaching genome-wide significance levels in Hispanic type 2 diabetes patients.

  4. Nuclear TCF4/TCF7L2 (show TCF4 Antibodies) expression affected the survival of patients with esophageal squamous cell carcinoma (ESCC). Positive expression of TCF4/TCF7L2 (show TCF4 Antibodies) was correlated with a poor prognosis after a curative operation in patients with ESCC.

  5. The results provide a strong evidence for independent association between type 2 diabetes mellitus and SNPs for in TCF7L2 and SLC30A8 (show SLC30A8 Antibodies).

  6. TCF7L2 mediates canonic Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling and c-Myc (show MYC Antibodies) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) to c-Myc (show MYC Antibodies) axis can be explored for preventing and treating heart failure.

  7. We identify the transcription factors FOXA1 (show FOXA1 Antibodies), MYB (show MYB Antibodies), CDX2 (show CDX2 Antibodies) and TCF7L2 as EPHB2 (show EPHB2 Antibodies) enhancer factors and demonstrate that Snail1 (show SNAI1 Antibodies) indirectly inactivates the EPHB2 (show EPHB2 Antibodies) enhancer by downregulation of FOXA1 (show FOXA1 Antibodies) and MYB (show MYB Antibodies)

  8. We found that TCF7L1 (show TCF3 Antibodies) recruits the C-terminal binding protein (CtBP (show CTBP2 Antibodies)) and histone deacetylase 1 (HDAC1 (show HDAC1 Antibodies)) to the DKK4 (show DKK4 Antibodies) promoter to repress DKK4 (show DKK4 Antibodies) gene expression. In the absence of TCF7L1 (show TCF3 Antibodies), TCF7L2 and beta-catenin (show CTNNB1 Antibodies) occupancy at the DKK4 (show DKK4 Antibodies) promoter is stimulated and DKK4 (show DKK4 Antibodies) expression is increased. These findings uncover a critical role for TCF7L1 (show TCF3 Antibodies) in repressing DKK4 (show DKK4 Antibodies) gene expression to promote the oncogenic potential of CRCs.

  9. nominally significant associations seen between TT genotype and the recessive model of TCF7L2 rs7903146 and increased risk of type 2 diabetes mellitus

  10. Genetic variation at TCF7L2 does not predispose an individual to type 2 diabetes by altering either hepatic or extrahepatic insulin (show INS Antibodies) action.

Cow (Bovine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. findings report an independent confirmation of the association of the TCF7L2 (show TCF4 Antibodies) gene with milk yield and composition traits.

Pig (Porcine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Genes implied in human type 2 diabetes development, TCF7L2, WFS1 (show WFS1 Antibodies), FTO (show FTO Antibodies), SLC30A8 (show SLC30A8 Antibodies), and GCKR (show GCKR Antibodies), were mapped on Sus scrofa chromosomes 14, 8, 6, 4, and 3, respectively. Only TCF7L2 was significantly associated with five fat traits in pigs.

TCF7L2 Antigen Profile

Antigen Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.

Alternative names and synonyms associated with TCF7L2

  • transcription factor 7-like 2 (T-cell specific, HMG-box) (LOC100229459) antibody
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2) antibody
  • transcription factor 7 like 2, T cell specific, HMG box (Tcf7l2) antibody
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (tcf7l2) antibody
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (Tcf7l2) antibody
  • mTcf-4B antibody
  • mTcf-4E antibody
  • TCF-4 antibody
  • TCF4 antibody
  • TCF4B antibody
  • tcf4e antibody
  • TCFL2 antibody
  • XTCF-4 antibody

Protein level used designations for TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box) , HMG box transcription factor 4 , T-cell factor 4 , T-cell-specific transcription factor 4 , mTCF-4 , transcription factor 7-like 2 , transcription factor 7-like 2, T-cell specific, HMG-box , transcription factor tcf4 , T-cell factor XTCF-4A , transcription factor Tcf4 , T-cell factor-4 variant A , T-cell factor-4 variant B , T-cell factor-4 variant C , T-cell factor-4 variant D , T-cell factor-4 variant E , T-cell factor-4 variant F , T-cell factor-4 variant G , T-cell factor-4 variant H , T-cell factor-4 variant I , T-cell factor-4 variant J , T-cell factor-4 variant K , T-cell factor-4 variant L , T-cell factor-4 variant M , T-cell factor-4 variant X2 , hTCF-4

GENE ID SPECIES
100229459 Taeniopygia guttata
100545943 Meleagris gallopavo
21416 Mus musculus
30510 Danio rerio
399164 Xenopus laevis
395508 Gallus gallus
6934 Homo sapiens
540481 Bos taurus
679869 Rattus norvegicus
100153922 Sus scrofa
486894 Canis lupus familiaris
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