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Browse our anti-TCF7L2 (TCF7L2) Antibodies

Full name:
anti-Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) Antibodies (TCF7L2)
On www.antibodies-online.com are 104 Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) Antibodies from 17 different suppliers available. Additionally we are shipping TCF7L2 Kits (4) and TCF7L2 Proteins (4) and many more products for this protein. A total of 119 TCF7L2 products are currently listed.
Synonyms:
mTcf-4B, mTcf-4E, TCF-4, TCF4, TCF4B, tcf4e, TCFL2, XTCF-4
list all antibodies Gene Name GeneID UniProt
TCF7L2 21416 Q924A0
TCF7L2 6934 Q9NQB0
TCF7L2 679869  

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Most Popular Reactivities for anti-TCF7L2 (TCF7L2) Antibodies

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anti-Mouse (Murine) TCF7L2 Antibodies:

anti-Human TCF7L2 Antibodies:

anti-Rat (Rattus) TCF7L2 Antibodies:

All available anti-TCF7L2 Antibodies

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Top referenced anti-TCF7L2 Antibodies

  1. Human Monoclonal TCF7L2 Primary Antibody for IF, WB - ABIN394207 : Heni, Ketterer, Thamer, Herzberg-Schäfer, Guthoff, Stefan, Machicao, Staiger, Fritsche, Häring: Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. in Diabetes 2010 (PubMed)
    Show all 5 references for ABIN394207

  2. Human Monoclonal TCF7L2 Primary Antibody for IHC (p), ELISA - ABIN520776 : da Silva Xavier, Loder, McDonald, Tarasov, Carzaniga, Kronenberger, Barg, Rutter: TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. in Diabetes 2009 (PubMed)
    Show all 2 references for ABIN520776

  3. Human Polyclonal TCF7L2 Primary Antibody for EIA, WB - ABIN955128 : Hansson, Zhou, Renström, Osmark: Molecular function of TCF7L2: Consequences of TCF7L2 splicing for molecular function and risk for type 2 diabetes. in Current diabetes reports 2010 (PubMed)
    Show all 2 references for ABIN955128

  4. Chicken Polyclonal TCF7L2 Primary Antibody for WB - ABIN2777927 : Ren, Han, Wang, Zhang, Han, Luo, Zhou, Ji: Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population. in Diabetologia 2008 (PubMed)

More Antibodies against TCF7L2 Interaction Partners

Mouse (Murine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. results indicate that miR (show MLXIP Antibodies)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) and Wnt (show WNT2 Antibodies) signaling pathway by directly targeting Smad7 (show SMAD7 Antibodies) and Tcf7l2

  2. Tcf7l2 protein levels decline upon initiation of endocrine differentiation in vivo, disclosing the downregulation of this factor in the developing endocrine compartment.

  3. Kaiso (show ZBTB33 Antibodies) and Sox10 (show SOX10 Antibodies) sequentially interact with Tcf7l2 to coordinate the maturation of oligodendrocyte.

  4. Tcf7l2 plays a cell autonomous role in the control of beta cell function and mass, serving as an important regulator of gene expression and islet cell coordination

  5. Tcf7l2 is regulating proinsulin (show INS Antibodies) expression directly via Isl1 (show ISL1 Antibodies), Ins1 and indirectly via MafA (show MAFA Antibodies), NeuroD1 (show NEUROD1 Antibodies) and Pdx1 (show PDX1 Antibodies).

  6. Transcription factor 7-like 2 positively regulates neonatal and postnatal mouse oligodendrocyte differentiation during developmental myelination and remyelination in a manner independent of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.

  7. TCF7L2 expressed in the pancreatic beta cells plays a crucial role in glucose metabolism through regulation of the beta cell mass.

  8. Marked expression of TCF7L2 in oligodendrocytes is restricted to a well defined time period during developmental myelination in human and mouse central nervous system tissue samples.

  9. 5-FU acutely induces the severe myelin degeneration in adolescence and disruption of TCF7L2/HDAC1/HDAC2 (show HDAC1 Antibodies) complex is at least partially involved in 5-FU-induced demyelination.

  10. Knockdown of TCF7L2 blocked the malondialdehyde-induced glucose-stimulated insulin (show INS Antibodies) secretion elevation.

Zebrafish Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries.

  2. Dorsal and ventral habenulae develop in different regions of prosomere 2. In the process of ventral habenula formation, functional tcf7l2 gene activity is required and in its absence, ventral habenular neurons do not develop.

  3. In embryos, the tcf4 gene is highly regulated at the level of RNA splicing such that the variant proteins that are produced contain or lack domains proposed to be essential in repression or activation of transcription.

  4. Study underscores the involvement of Tcf4 in maintaining proliferative self-renewal in the intestine throughout life.

  5. This study reveals that Tcf4 (tcf7l2) is the major effector of Wnt (show WNT2 Antibodies) signaling in the intestine during zebrafish organogenesis.

Xenopus laevis Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. XTcf4 has no repressive role but is required to activate expression of Xnr3 and chordin (show CHRD Antibodies) in organizer cells at the gastrula stage

  2. regulation of XTcf-4 by canonical wnt (show WNT2 Antibodies)-signaling is directly controlled by binding to and activating a consensus Lef/Tcf (show HNF4A Antibodies) binding site within its own promoter

Human Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. TCF7L2 rs7903146 TT genotype was associated with gastric cancer risk under the recessive genetic model. There was no association between rs12255372 SNP and the susceptibility to developing gastric cancer.

  2. Obesity interacted with the TCF7L2-rs7903146 on Type 2 Diabetes(T2D) prevalence. Association of TCF7L2 polymorphism with T2D incidence was stronger in non-obese than in obese subjects. TCF7L2 predictive value was higher in non-obese subjects. We created obesity-specific genetic risk score with ten T2D-polymorphisms and demonstrated for the first time their higher strata-specific predictive value for T2D risk.

  3. TCF-4 (show TCF4 Antibodies) is a co-activator of NF-kappaB (show NFKB1 Antibodies) p65 (show GORASP1 Antibodies) that promotes MMP-15 (show MMP15 Antibodies) transcription and potentiate the migration activity of the lung cancer cells

  4. Studied associations between the TCF7L2 rs7903146 SNP and T2DM as well as evaluated its association with obesity in a sample of Taiwanese adults.

  5. Our findings demonstrate that ENPP1 (show ENPP1 Antibodies), TCF7L2, and FTO (show FTO Antibodies) may predispose to T2DM in the mixed-ancestry population.

  6. The results showed that the rs7903146 T allele of the TCF7L2 gene was positively correlated with an enhanced risk of type 2 diabetes mellitus in the allelic, heterozygote, homozygote, dominant, and recessive models. (Meta-analysis)

  7. Patients with the T/T genotype for the rs12255372 polymorphism of the transcription factor 7- like 2 gene present an increased colorectal cancer risk.

  8. We conclude that the TCF7L2 rs7903146 genetic polymorphism is independently associated with the risk of developing type 2 diabetes mellitus under co-dominant, dominant, and recessive models

  9. The strongest evidence of the TCF7L2 - Body Mass Index interaction was observed for rs7895307 SNP.

  10. TCF7L2 was associated with increased risk of impaired glucose metabolism.

Cow (Bovine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. findings report an independent confirmation of the association of the TCF7L2 (show TCF4 Antibodies) gene with milk yield and composition traits.

Pig (Porcine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Genes implied in human type 2 diabetes development, TCF7L2, WFS1 (show WFS1 Antibodies), FTO (show FTO Antibodies), SLC30A8 (show SLC30A8 Antibodies), and GCKR (show GCKR Antibodies), were mapped on Sus scrofa chromosomes 14, 8, 6, 4, and 3, respectively. Only TCF7L2 was significantly associated with five fat traits in pigs.

TCF7L2 Antigen Profile

Antigen Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.

Alternative names and synonyms associated with TCF7L2

  • transcription factor 7-like 2 (T-cell specific, HMG-box) (LOC100229459) antibody
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2) antibody
  • transcription factor 7 like 2, T cell specific, HMG box (Tcf7l2) antibody
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (tcf7l2) antibody
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (Tcf7l2) antibody
  • mTcf-4B antibody
  • mTcf-4E antibody
  • TCF-4 antibody
  • TCF4 antibody
  • TCF4B antibody
  • tcf4e antibody
  • TCFL2 antibody
  • XTCF-4 antibody

Protein level used designations for TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box) , HMG box transcription factor 4 , T-cell factor 4 , T-cell-specific transcription factor 4 , mTCF-4 , transcription factor 7-like 2 , transcription factor 7-like 2, T-cell specific, HMG-box , transcription factor tcf4 , T-cell factor XTCF-4A , transcription factor Tcf4 , T-cell factor-4 variant A , T-cell factor-4 variant B , T-cell factor-4 variant C , T-cell factor-4 variant D , T-cell factor-4 variant E , T-cell factor-4 variant F , T-cell factor-4 variant G , T-cell factor-4 variant H , T-cell factor-4 variant I , T-cell factor-4 variant J , T-cell factor-4 variant K , T-cell factor-4 variant L , T-cell factor-4 variant M , T-cell factor-4 variant X2 , hTCF-4

GENE ID SPECIES
100229459 Taeniopygia guttata
100545943 Meleagris gallopavo
21416 Mus musculus
30510 Danio rerio
399164 Xenopus laevis
395508 Gallus gallus
6934 Homo sapiens
540481 Bos taurus
679869 Rattus norvegicus
100153922 Sus scrofa
486894 Canis lupus familiaris
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