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Browse our TCF7L2 Proteins (TCF7L2)

Full name:
Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) Proteins (TCF7L2)
On www.antibodies-online.com are 4 Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) Proteins from 2 different suppliers available. Additionally we are shipping TCF7L2 Antibodies (102) and TCF7L2 Kits (5) and many more products for this protein. A total of 118 TCF7L2 products are currently listed.
Synonyms:
mTcf-4B, mTcf-4E, TCF-4, TCF4, TCF4B, tcf4e, TCFL2, XTCF-4
list all proteins Gene Name GeneID UniProt
TCF7L2 21416 Q924A0
TCF7L2 6934 Q9NQB0
Rat TCF7L2 TCF7L2 679869  

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TCF7L2 Proteins (TCF7L2) by Origin

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Top referenced TCF7L2 Proteins

  1. Human TCF7L2 Protein expressed in Wheat germ - ABIN1322376 : Shitashige, Satow, Honda, Ono, Hirohashi, Yamada: Regulation of Wnt signaling by the nuclear pore complex. in Gastroenterology 2008 (PubMed)

More Proteins for TCF7L2 Interaction Partners

Mouse (Murine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. TCF7L2 mediates canonic Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling and c-Myc (show MYC Proteins) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) to c-Myc (show MYC Proteins) axis can be explored for preventing and treating heart failure.

  2. These findings suggest a unique role for Tcf7l2 in generating distinct neuronal phenotypes from homogeneous progenitor population.

  3. Tcf7l2 may be involved in maintenance of stem/progenitor cells properties.

  4. results indicate that miR (show MLXIP Proteins)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) and Wnt (show WNT2 Proteins) signaling pathway by directly targeting Smad7 (show SMAD7 Proteins) and Tcf7l2

  5. Tcf7l2 protein levels decline upon initiation of endocrine differentiation in vivo, disclosing the downregulation of this factor in the developing endocrine compartment.

  6. Kaiso (show ZBTB33 Proteins) and Sox10 (show SOX10 Proteins) sequentially interact with Tcf7l2 to coordinate the maturation of oligodendrocyte.

  7. Tcf7l2 plays a cell autonomous role in the control of beta cell function and mass, serving as an important regulator of gene expression and islet cell coordination

  8. Tcf7l2 is regulating proinsulin (show INS Proteins) expression directly via Isl1 (show ISL1 Proteins), Ins1 and indirectly via MafA (show MAFA Proteins), NeuroD1 (show NEUROD1 Proteins) and Pdx1 (show PDX1 Proteins).

  9. Transcription factor 7-like 2 positively regulates neonatal and postnatal mouse oligodendrocyte differentiation during developmental myelination and remyelination in a manner independent of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway.

  10. TCF7L2 expressed in the pancreatic beta cells plays a crucial role in glucose metabolism through regulation of the beta cell mass.

Zebrafish Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries.

  2. Dorsal and ventral habenulae develop in different regions of prosomere 2. In the process of ventral habenula formation, functional tcf7l2 gene activity is required and in its absence, ventral habenular neurons do not develop.

  3. In embryos, the tcf4 gene is highly regulated at the level of RNA splicing such that the variant proteins that are produced contain or lack domains proposed to be essential in repression or activation of transcription.

  4. Study underscores the involvement of Tcf4 in maintaining proliferative self-renewal in the intestine throughout life.

  5. This study reveals that Tcf4 (tcf7l2) is the major effector of Wnt (show WNT2 Proteins) signaling in the intestine during zebrafish organogenesis.

Xenopus laevis Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. XTcf4 has no repressive role but is required to activate expression of Xnr3 and chordin (show CHRD Proteins) in organizer cells at the gastrula stage

  2. regulation of XTcf-4 by canonical wnt (show WNT2 Proteins)-signaling is directly controlled by binding to and activating a consensus Lef/Tcf (show HNF4A Proteins) binding site within its own promoter

Human Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. TCF7L2 mediates canonic Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling and c-Myc (show MYC Proteins) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) to c-Myc (show MYC Proteins) axis can be explored for preventing and treating heart failure.

  2. We identify the transcription factors FOXA1 (show FOXA1 Proteins), MYB (show MYB Proteins), CDX2 (show CDX2 Proteins) and TCF7L2 as EPHB2 (show EPHB2 Proteins) enhancer factors and demonstrate that Snail1 (show SNAI1 Proteins) indirectly inactivates the EPHB2 (show EPHB2 Proteins) enhancer by downregulation of FOXA1 (show FOXA1 Proteins) and MYB (show MYB Proteins)

  3. We found that TCF7L1 (show TCF3 Proteins) recruits the C-terminal binding protein (CtBP (show CTBP2 Proteins)) and histone deacetylase 1 (HDAC1 (show HDAC1 Proteins)) to the DKK4 (show DKK4 Proteins) promoter to repress DKK4 (show DKK4 Proteins) gene expression. In the absence of TCF7L1 (show TCF3 Proteins), TCF7L2 and beta-catenin (show CTNNB1 Proteins) occupancy at the DKK4 (show DKK4 Proteins) promoter is stimulated and DKK4 (show DKK4 Proteins) expression is increased. These findings uncover a critical role for TCF7L1 (show TCF3 Proteins) in repressing DKK4 (show DKK4 Proteins) gene expression to promote the oncogenic potential of CRCs.

  4. nominally significant associations seen between TT genotype and the recessive model of TCF7L2 rs7903146 and increased risk of type 2 diabetes mellitus

  5. Genetic variation at TCF7L2 does not predispose an individual to type 2 diabetes by altering either hepatic or extrahepatic insulin (show INS Proteins) action.

  6. In the sex-combined analyses, we identified one novel locus (TCF7L2/HABP2) for WHRadjBMI and eight previously established loci at P < 5x10-8: seven for BMI, and one for WHRadjBMI in African ancestry individuals. An additional novel locus (SPRYD7/DLEU2) was identified for WHRadjBMI when combined with European GWAS.

  7. In renal transplant patients, TCF7L2 rs7903146 is strongly and independently associated with posttransplant diabetes mellitus and might hold the potential to identify patients at risk for this complication.

  8. Insulin (show INS Proteins) resistance and sex influence plasma free fatty acid responses amongst carriers of the minor T allele of TCF7L2 rs7903146

  9. TCF7L2 is a direct target gene of miR (show MLXIP Proteins)-328 in cervical cancer.

  10. TCF7L2 rs7903146 TT genotype was associated with gastric cancer risk under the recessive genetic model. There was no association between rs12255372 SNP and the susceptibility to developing gastric cancer.

Cow (Bovine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. findings report an independent confirmation of the association of the TCF7L2 (show TCF4 Proteins) gene with milk yield and composition traits.

Pig (Porcine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Genes implied in human type 2 diabetes development, TCF7L2, WFS1 (show WFS1 Proteins), FTO (show FTO Proteins), SLC30A8 (show SLC30A8 Proteins), and GCKR (show GCKR Proteins), were mapped on Sus scrofa chromosomes 14, 8, 6, 4, and 3, respectively. Only TCF7L2 was significantly associated with five fat traits in pigs.

TCF7L2 Protein Profile

Protein Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.

Alternative names and synonyms associated with TCF7L2

  • transcription factor 7-like 2 (T-cell specific, HMG-box) (LOC100229459)
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2)
  • transcription factor 7 like 2, T cell specific, HMG box (Tcf7l2)
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (tcf7l2)
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (Tcf7l2)
  • mTcf-4B protein
  • mTcf-4E protein
  • TCF-4 protein
  • TCF4 protein
  • TCF4B protein
  • tcf4e protein
  • TCFL2 protein
  • XTCF-4 protein

Protein level used designations for TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box) , HMG box transcription factor 4 , T-cell factor 4 , T-cell-specific transcription factor 4 , mTCF-4 , transcription factor 7-like 2 , transcription factor 7-like 2, T-cell specific, HMG-box , transcription factor tcf4 , T-cell factor XTCF-4A , transcription factor Tcf4 , T-cell factor-4 variant A , T-cell factor-4 variant B , T-cell factor-4 variant C , T-cell factor-4 variant D , T-cell factor-4 variant E , T-cell factor-4 variant F , T-cell factor-4 variant G , T-cell factor-4 variant H , T-cell factor-4 variant I , T-cell factor-4 variant J , T-cell factor-4 variant K , T-cell factor-4 variant L , T-cell factor-4 variant M , T-cell factor-4 variant X2 , hTCF-4

GENE ID SPECIES
100229459 Taeniopygia guttata
100545943 Meleagris gallopavo
21416 Mus musculus
30510 Danio rerio
399164 Xenopus laevis
395508 Gallus gallus
6934 Homo sapiens
540481 Bos taurus
679869 Rattus norvegicus
100153922 Sus scrofa
486894 Canis lupus familiaris
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