Browse our TCF7L2 Proteins (TCF7L2)

Full name:
Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) Proteins (TCF7L2)
On are 4 Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) Proteins from 2 different suppliers available. Additionally we are shipping TCF7L2 Antibodies (103) and TCF7L2 Kits (6) and many more products for this protein. A total of 120 TCF7L2 products are currently listed.
mTcf-4B, mTcf-4E, TCF-4, TCF4, TCF4B, tcf4e, TCFL2, XTCF-4
list all proteins Gene Name GeneID UniProt
TCF7L2 21416 Q924A0
TCF7L2 6934 Q9NQB0
Rat TCF7L2 TCF7L2 679869  

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TCF7L2 Proteins (TCF7L2) by Origin

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Top referenced TCF7L2 Proteins

  1. Human TCF7L2 Protein expressed in Wheat germ - ABIN1322376 : Shitashige, Satow, Honda, Ono, Hirohashi, Yamada: Regulation of Wnt signaling by the nuclear pore complex. in Gastroenterology 2008 (PubMed)

More Proteins for TCF7L2 Interaction Partners

Mouse (Murine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. TCF7L2 mediates canonic Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling and c-Myc (show MYC Proteins) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) to c-Myc (show MYC Proteins) axis can be explored for preventing and treating heart failure.

  2. These findings suggest a unique role for Tcf7l2 in generating distinct neuronal phenotypes from homogeneous progenitor population.

  3. Tcf7l2 may be involved in maintenance of stem/progenitor cells properties.

  4. results indicate that miR (show MLXIP Proteins)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) and Wnt (show WNT2 Proteins) signaling pathway by directly targeting Smad7 (show SMAD7 Proteins) and Tcf7l2

  5. Tcf7l2 protein levels decline upon initiation of endocrine differentiation in vivo, disclosing the downregulation of this factor in the developing endocrine compartment.

  6. Kaiso (show ZBTB33 Proteins) and Sox10 (show SOX10 Proteins) sequentially interact with Tcf7l2 to coordinate the maturation of oligodendrocyte.

  7. Tcf7l2 plays a cell autonomous role in the control of beta cell function and mass, serving as an important regulator of gene expression and islet cell coordination

  8. Tcf7l2 is regulating proinsulin (show INS Proteins) expression directly via Isl1 (show ISL1 Proteins), Ins1 and indirectly via MafA (show MAFA Proteins), NeuroD1 (show NEUROD1 Proteins) and Pdx1 (show PDX1 Proteins).

  9. Transcription factor 7-like 2 positively regulates neonatal and postnatal mouse oligodendrocyte differentiation during developmental myelination and remyelination in a manner independent of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway.

  10. TCF7L2 expressed in the pancreatic beta cells plays a crucial role in glucose metabolism through regulation of the beta cell mass.

Zebrafish Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries.

  2. Dorsal and ventral habenulae develop in different regions of prosomere 2. In the process of ventral habenula formation, functional tcf7l2 gene activity is required and in its absence, ventral habenular neurons do not develop.

  3. In embryos, the tcf4 gene is highly regulated at the level of RNA splicing such that the variant proteins that are produced contain or lack domains proposed to be essential in repression or activation of transcription.

  4. Study underscores the involvement of Tcf4 in maintaining proliferative self-renewal in the intestine throughout life.

  5. This study reveals that Tcf4 (tcf7l2) is the major effector of Wnt (show WNT2 Proteins) signaling in the intestine during zebrafish organogenesis.

Xenopus laevis Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. XTcf4 has no repressive role but is required to activate expression of Xnr3 and chordin (show CHRD Proteins) in organizer cells at the gastrula stage

  2. regulation of XTcf-4 by canonical wnt (show WNT2 Proteins)-signaling is directly controlled by binding to and activating a consensus Lef/Tcf (show HNF4A Proteins) binding site within its own promoter

Human Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. These findings suggest that the rs7903146 locus might exert its enhancer function by interacting with HMGB1 (show HMGB1 Proteins) in an allele dependent manner.

  2. TCF7L2 polymorphism is associated with colorectal cancer.

  3. Data show that FERM domain-containing protein 5 (FRMD5) is regulated by both beta-catenin and transcription factor 7-Like 2 protein (TCF7L2) in colon cancer cells.

  4. the variation of the TCF7L2 gene in three Amerindian populations

  5. These data define the mechanism responsible for the repressive effects of nitric oxide (NO) on the transcriptional activity of beta-catenin (show CTNNB1 Proteins) and link eNOS (show NOS3 Proteins)-derived NO to the modulation by VEGF (show VEGFA Proteins) of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-induced endothelial cell proliferation.

  6. we show that TopoIIalpha forms protein-protein interactions with beta-catentin and TCF4 (show TCF4 Proteins) and interacts with Wnt (show WNT2 Proteins) response elements (WREs) and promoters of direct target genes of TCF (show HNF4A Proteins) transcription, including: MYC (show MYC Proteins), vimentin (show VIM Proteins), AXIN2 (show AXIN2 Proteins) and LEF1 (show LEF1 Proteins)

  7. novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women

  8. GWAS identified two known loci (TCF7L2 and KCNQ1 (show KCNQ1 Proteins)) reaching genome-wide significance levels in Hispanic type 2 diabetes patients.

  9. Nuclear TCF4/TCF7L2 (show TCF4 Proteins) expression affected the survival of patients with esophageal squamous cell carcinoma (ESCC). Positive expression of TCF4/TCF7L2 (show TCF4 Proteins) was correlated with a poor prognosis after a curative operation in patients with ESCC.

  10. The results provide a strong evidence for independent association between type 2 diabetes mellitus and SNPs for in TCF7L2 and SLC30A8 (show SLC30A8 Proteins).

Cow (Bovine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. findings report an independent confirmation of the association of the TCF7L2 (show TCF4 Proteins) gene with milk yield and composition traits.

Pig (Porcine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Genes implied in human type 2 diabetes development, TCF7L2, WFS1 (show WFS1 Proteins), FTO (show FTO Proteins), SLC30A8 (show SLC30A8 Proteins), and GCKR (show GCKR Proteins), were mapped on Sus scrofa chromosomes 14, 8, 6, 4, and 3, respectively. Only TCF7L2 was significantly associated with five fat traits in pigs.

TCF7L2 Protein Profile

Protein Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.

Alternative names and synonyms associated with TCF7L2

  • transcription factor 7-like 2 (T-cell specific, HMG-box) (LOC100229459)
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2)
  • transcription factor 7 like 2, T cell specific, HMG box (Tcf7l2)
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (tcf7l2)
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (Tcf7l2)
  • mTcf-4B protein
  • mTcf-4E protein
  • TCF-4 protein
  • TCF4 protein
  • TCF4B protein
  • tcf4e protein
  • TCFL2 protein
  • XTCF-4 protein

Protein level used designations for TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box) , HMG box transcription factor 4 , T-cell factor 4 , T-cell-specific transcription factor 4 , mTCF-4 , transcription factor 7-like 2 , transcription factor 7-like 2, T-cell specific, HMG-box , transcription factor tcf4 , T-cell factor XTCF-4A , transcription factor Tcf4 , T-cell factor-4 variant A , T-cell factor-4 variant B , T-cell factor-4 variant C , T-cell factor-4 variant D , T-cell factor-4 variant E , T-cell factor-4 variant F , T-cell factor-4 variant G , T-cell factor-4 variant H , T-cell factor-4 variant I , T-cell factor-4 variant J , T-cell factor-4 variant K , T-cell factor-4 variant L , T-cell factor-4 variant M , T-cell factor-4 variant X2 , hTCF-4

100229459 Taeniopygia guttata
100545943 Meleagris gallopavo
21416 Mus musculus
30510 Danio rerio
399164 Xenopus laevis
395508 Gallus gallus
6934 Homo sapiens
540481 Bos taurus
679869 Rattus norvegicus
100153922 Sus scrofa
486894 Canis lupus familiaris
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