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Browse our TCF7L2 Proteins (TCF7L2)

Full name:
Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) Proteins (TCF7L2)
On www.antibodies-online.com are 4 Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) Proteins from 2 different suppliers available. Additionally we are shipping TCF7L2 Antibodies (89) and TCF7L2 Kits (3) and many more products for this protein. A total of 103 TCF7L2 products are currently listed.
Synonyms:
mTcf-4B, mTcf-4E, TCF-4, TCF4, TCF4B, tcf4e, TCFL2, XTCF-4
list all proteins Gene Name GeneID UniProt
TCF7L2 21416 Q924A0
TCF7L2 6934 Q9NQB0
Rat TCF7L2 TCF7L2 679869  

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TCF7L2 Proteins (TCF7L2) by Origin

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Top referenced TCF7L2 Proteins

  1. Human TCF7L2 Protein expressed in Wheat germ - ABIN1322376 : Shitashige, Satow, Honda, Ono, Hirohashi, Yamada: Regulation of Wnt signaling by the nuclear pore complex. in Gastroenterology 2008 (PubMed)

More Proteins for TCF7L2 Interaction Partners

Mouse (Murine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Kaiso (show ZBTB33 Proteins) and Sox10 (show SOX10 Proteins) sequentially interact with Tcf7l2 to coordinate the maturation of oligodendrocyte.

  2. Tcf7l2 plays a cell autonomous role in the control of beta cell function and mass, serving as an important regulator of gene expression and islet cell coordination

  3. Tcf7l2 is regulating proinsulin (show INS Proteins) expression directly via Isl1 (show ISL1 Proteins), Ins1 and indirectly via MafA (show MAFA Proteins), NeuroD1 (show NEUROD1 Proteins) and Pdx1 (show PDX1 Proteins).

  4. Transcription factor 7-like 2 positively regulates neonatal and postnatal mouse oligodendrocyte differentiation during developmental myelination and remyelination in a manner independent of the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway.

  5. TCF7L2 expressed in the pancreatic beta cells plays a crucial role in glucose metabolism through regulation of the beta cell mass.

  6. Marked expression of TCF7L2 in oligodendrocytes is restricted to a well defined time period during developmental myelination in human and mouse central nervous system tissue samples.

  7. 5-FU acutely induces the severe myelin degeneration in adolescence and disruption of TCF7L2/HDAC1/HDAC2 (show HDAC1 Proteins) complex is at least partially involved in 5-FU-induced demyelination.

  8. Knockdown of TCF7L2 blocked the malondialdehyde-induced glucose-stimulated insulin (show INS Proteins) secretion elevation.

  9. This is the first report to show that DIF-1 inhibits tumor growth in vivo, consistent with its in-vitro action, suggesting that this compound may have potential as a novel anti-tumor agent.

  10. The dominant-negative isoforms of TCF7L2 are predominant in the embryonic thalamus but disappear postnatally.

Zebrafish Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries.

  2. Dorsal and ventral habenulae develop in different regions of prosomere 2. In the process of ventral habenula formation, functional tcf7l2 gene activity is required and in its absence, ventral habenular neurons do not develop.

  3. In embryos, the tcf4 gene is highly regulated at the level of RNA splicing such that the variant proteins that are produced contain or lack domains proposed to be essential in repression or activation of transcription.

  4. Study underscores the involvement of Tcf4 in maintaining proliferative self-renewal in the intestine throughout life.

  5. This study reveals that Tcf4 (tcf7l2) is the major effector of Wnt (show WNT2 Proteins) signaling in the intestine during zebrafish organogenesis.

Xenopus laevis Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. XTcf4 has no repressive role but is required to activate expression of Xnr3 and chordin (show CHRD Proteins) in organizer cells at the gastrula stage

  2. regulation of XTcf-4 by canonical wnt (show WNT2 Proteins)-signaling is directly controlled by binding to and activating a consensus Lef/Tcf (show HNF4A Proteins) binding site within its own promoter

Human Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. TCF7L2 was associated with increased risk of impaired glucose metabolism.

  2. Data indicate that triglycerides were significantly associated with the T risk allele of the transcription factor 7-like 2 (TCF7L2) gene.

  3. Transcription factor 7-like 2 (TCF7L2) gene encodes the TCF-4 (show TCF4 Proteins) transcription factor, which forms a part of the Wnt (show WNT2 Proteins) signaling pathway.

  4. The T allele of TCF7L2 rs7903146 polymorphism was associated with susceptibility of gestational diabetes mellitus in overall population in white, Hispanic/Latino and Asian sub-groups. Meta-analysis.

  5. Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (show ADCY5 Proteins), ADRA2A (show ADRA2A Proteins), CDKAL1 (show CDKAL1 Proteins), CDKN2A/B, GRB10 (show GRB10 Proteins), and TCF7L2

  6. The T-allele frequencies of TCF7L2 polymorphisms rs12255372 and rs7903146 were 30% (26-35%), 32% (27-37%) and 29% (25-34%), 36% (31-41%), respectively.

  7. Despite limited sample size, the study indicates that rs7903146-T allele in TCF7L2 was associated with higher mean nocturnal glucose dependent on body composition, which might suggest that rs7902146 affects liver-specific aspects of glucose metabolism.

  8. TCF7L2 rs10885409 C allele is a T2DM risk factor in Emiratis; this association is modulated by obesity status, but the Pro12Ala mutation in PPAR-gamma2 (show PPARG Proteins) is not associated with T2DM risk in this population

  9. rs12255372 and rs4506565 variants(but not rs7903146) of TCF7L2 show an association with type 2 diabetes mellitus for the Saudi population of the Eastern Province of Saudi Arabia

  10. the TCF7L2 rs12255372 (G>T) polymorphism might be one of the most important genetic factors associated with T2DM susceptibility.

Cow (Bovine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. findings report an independent confirmation of the association of the TCF7L2 (show TCF4 Proteins) gene with milk yield and composition traits.

Pig (Porcine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) interaction partners

  1. Genes implied in human type 2 diabetes development, TCF7L2, WFS1 (show WFS1 Proteins), FTO (show FTO Proteins), SLC30A8 (show SLC30A8 Proteins), and GCKR (show GCKR Proteins), were mapped on Sus scrofa chromosomes 14, 8, 6, 4, and 3, respectively. Only TCF7L2 was significantly associated with five fat traits in pigs.

TCF7L2 Protein Profile

Protein Summary

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.

Alternative names and synonyms associated with TCF7L2

  • transcription factor 7-like 2 (T-cell specific, HMG-box) (LOC100229459)
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2)
  • transcription factor 7 like 2, T cell specific, HMG box (Tcf7l2)
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (tcf7l2)
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (Tcf7l2)
  • mTcf-4B protein
  • mTcf-4E protein
  • TCF-4 protein
  • TCF4 protein
  • TCF4B protein
  • tcf4e protein
  • TCFL2 protein
  • XTCF-4 protein

Protein level used designations for TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box) , HMG box transcription factor 4 , T-cell factor 4 , T-cell-specific transcription factor 4 , mTCF-4 , transcription factor 7-like 2 , transcription factor 7-like 2, T-cell specific, HMG-box , transcription factor tcf4 , T-cell factor XTCF-4A , transcription factor Tcf4 , T-cell factor-4 variant A , T-cell factor-4 variant B , T-cell factor-4 variant C , T-cell factor-4 variant D , T-cell factor-4 variant E , T-cell factor-4 variant F , T-cell factor-4 variant G , T-cell factor-4 variant H , T-cell factor-4 variant I , T-cell factor-4 variant J , T-cell factor-4 variant K , T-cell factor-4 variant L , T-cell factor-4 variant M , T-cell factor-4 variant X2 , hTCF-4

GENE ID SPECIES
100229459 Taeniopygia guttata
100545943 Meleagris gallopavo
21416 Mus musculus
30510 Danio rerio
399164 Xenopus laevis
395508 Gallus gallus
6934 Homo sapiens
540481 Bos taurus
679869 Rattus norvegicus
100153922 Sus scrofa
486894 Canis lupus familiaris
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