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Human WNT5A Protein expressed in Wheat germ - ABIN1325364
Bazhin, Tambor, Dikov, Philippov, Schadendorf, Eichmüller: cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. in Cellular and molecular life sciences : CMLS 2010
There is an important role of Wnt5a in kidney development. Disrupted Wnt5a results in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.
Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours
This study describes the localization and functional role of WNT-5A in human and mouse fibrotic livers. Hepatic WNT-5A expression parallels collagen type I expression. In vivo and in vitro, the myofibroblasts were identified as the key hepatic cells producing WNT-5A. WNT-5A is under control of TGF-beta (show TGFB1 Proteins) and its activities are primarily profibrotic.
we confirmed the requirement of Wnt5a in the deferoxamine-mediated osteoblast-promoting effects by analyzing the matrix mineralization of Wnt5a-deficient cells. The promoting effect of deferoxamine on matrix mineralization in wild-type cells was completely abolished in Wnt5a(-/-) cells.
opposing gradients of Wnt5a and Wnt5b (show WNT5B Proteins) and of their Sfrp inhibitors, together with intercellular signaling via planar cell polarity proteins, polarize node cells along the anterior-posterior axis for breaking of left-right symmetry.
Wnt5a is responsible for maintaining effective communication between the stromal and epithelial compartments partly through the action of luminal and stromal secreted factors, Fgf10 (show FGF10 Proteins) and Ihh (show IHH Proteins).
findings reveal that FZD9 and heterotrimeric G proteins regulate Wnt-5a signaling and dendritic spines in cultured hippocampal neurons.
Here we show that an evolutionarily conserved genomic region named AS3_9 comprises three TEs (show TES Proteins) (AmnSINE1, X6b_DNA and MER117), inserted side-by-side, and functions as a distal enhancer for wnt5a expression during morphogenesis of the mammalian secondary palate.
we here reported that Wnt5a mediated activation of canonical Wnt (show WNT2 Proteins) signaling pathway might contribute to the orthodontic force induced bone remodeling.
Wnt5a deficiency can regulate inflammatory cytokine secretion, polarization, and apoptosis in MTB (show NCAPG2 Proteins)-infected macrophage
These results showed that Wnt5a could promote the maturation of mast cells via the canonical Wnt (show WNT2 Proteins) signaling pathway and provide important insights into the molecular mechanisms underlying the differentiation of mast cells
the CaMKK (show CAMKK2 Proteins)-CaMKIalpha (show CAMK1 Proteins) cascade is required for the axonal growth effect of Wnt5a during neuronal polarization.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2 (show ROR2 Proteins), which require Wnt5a/Ror2 (show ROR2 Proteins) signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (show PCDH8 Proteins) signaling via RhoA (show RHOA Proteins) and Wnt5a/Ror2 (show ROR2 Proteins) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Data show that Rspo3 (show RSPO3 Proteins) binds syndecan 4 and that together they activate Wnt5a/PCP (show PRCP Proteins) signaling.
In an examination of signaling pathways in developing Xenopus lung, wnt5a was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4 (show SDC4 Proteins) in dorsal mesodermal cells from Xenopus gastrulae.
Transcriptional regulation of XPAPC (show PCDH8 Proteins) by XWnt-5A requires the receptor tyrosine kinase Ror2 (show ROR2 Proteins).
Xwnt-5a plays an instructive role in larval tail regeneration via Wnt (show WNT2 Proteins)/JNK (show MAPK8 Proteins) signaling
this study shows that Wnt5a promotes differentiation of dendritic cells, but inhibits their maturation
Noncanonical Wnt (show WNT2 Proteins) signaling via Wnt5a/5b/11 may have role in the pathogenesis of aortic valve calcification.
Wnt5a was consistently upregulated in gastric cancer associated myofibroblasts.
we show that Wnt5a rapidly represses rDNA gene transcription in breast cancer cells and generates a chromatin state with reduced transcription of rDNA by RNA polymerase I (show POLR1C Proteins) (Pol I). These effects were specifically dependent on Dishevelled1 (DVL1 (show DVL1 Proteins)), which accumulates in nucleolar organizer regions (NORs) and binds to rDNA regions of the chromosome.
The mechanism may be that ghrelin (show GHRL Proteins) up-regulates the expression of cyclin D1 (show CCND1 Proteins) via regulating Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway, which has an intimate relationship with lung diseases. These results suggested the possible role of ghrelin (show GHRL Proteins) in treating diabetic lung diseases, especially in view of its low toxicity in humans.
5-FU-induced tumor suppression (reduced cell viability) was reduced by WNT5A overexpression in hypermethylated HCT116 and SW620 cells and enhanced by WNT5A downregulation in unmethylated LoVo and SW480 cells.
Study established a glioblastoma model that affords a direct comparison of genome-wide histone modifications and associated gene expression alterations between parental human neural stem cells and their derivative oncogene (show RAB1A Proteins)-induced glioblastoma stem cells (iGSCs), identifying PAX6 (show PAX6 Proteins)- and DLX5 (show DLX5 Proteins)-regulated WNT5A as a key factor driving iGSCs differentiation into GSC (show GSC Proteins) differentiation into endothelial-like cells (GdECs).
Wnt5a protein expression might contribute to the tumor progression and poor prognosis of triple-negative breast cancer
WNT5A is a negative regulator of FSH (show BRD2 Proteins)-stimulated granulosa cell steroidogenesis in cattle.
Wnt-5A may be associated with cartilage destruction by promoting the expression of matrix metalloproteinases.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
wingless-type MMTV integration site family, member 5A
, protein Wnt-5a
, protein Wnt-5a-like
, WNT-5A protein
, Wnt-5a protein
, wingless-related MMTV integration site 5A
, wingless-type MMTV integration site 5A