Browse our WNT5A Proteins (WNT5A)

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Wingless-Type MMTV Integration Site Family, Member 5A Proteins (WNT5A)
On are 19 Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A) Proteins from 7 different suppliers available. Additionally we are shipping WNT5A Antibodies (130) and WNT5A Kits (29) and many more products for this protein. A total of 184 WNT5A products are currently listed.
8030457G12Rik, hWNT5A, Wnt-5a, WNT5A, wnt5a-B
list all proteins Gene Name GeneID UniProt
WNT5A 7474 P41221
WNT5A 64566 Q9QXQ7
WNT5A 22418 P22725

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WNT5A Proteins (WNT5A) by Origin

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Top referenced WNT5A Proteins

  1. Human WNT5A Protein expressed in Wheat germ - ABIN1325364 : Bazhin, Tambor, Dikov, Philippov, Schadendorf, Eichmüller: cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. in Cellular and molecular life sciences : CMLS 2010 (PubMed)

More Proteins for WNT5A Interaction Partners

Zebrafish Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A) interaction partners

  1. There is an important role of Wnt5a in kidney development. Disrupted Wnt5a results in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.

  2. Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours

Mouse (Murine) Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A) interaction partners

  1. During mouse embryonic stem cell (ESC) in vitro osteogenesis, the noncanonical WNT5a is expressed early on.

  2. This study shows that Wnt5a is not required for development of the renal medulla and that loss of the renal medullary region in the Wnt5a-deleted kidney is caused by an abnormal ureter-bladder connection.

  3. WNT5A in the bone marrow niche is required to regenerate hematopoietic stem cells and leukemic cells with functional ability to rearrange the actin cytoskeleton and engraft successfully.

  4. This study describes the localization and functional role of WNT-5A in human and mouse fibrotic livers. Hepatic WNT-5A expression parallels collagen type I expression. In vivo and in vitro, the myofibroblasts were identified as the key hepatic cells producing WNT-5A. WNT-5A is under control of TGF-beta (show TGFB1 Proteins) and its activities are primarily profibrotic.

  5. we confirmed the requirement of Wnt5a in the deferoxamine-mediated osteoblast-promoting effects by analyzing the matrix mineralization of Wnt5a-deficient cells. The promoting effect of deferoxamine on matrix mineralization in wild-type cells was completely abolished in Wnt5a(-/-) cells.

  6. opposing gradients of Wnt5a and Wnt5b (show WNT5B Proteins) and of their Sfrp inhibitors, together with intercellular signaling via planar cell polarity proteins, polarize node cells along the anterior-posterior axis for breaking of left-right symmetry.

  7. Wnt5a is responsible for maintaining effective communication between the stromal and epithelial compartments partly through the action of luminal and stromal secreted factors, Fgf10 (show FGF10 Proteins) and Ihh (show IHH Proteins).

  8. findings reveal that FZD9 and heterotrimeric G proteins regulate Wnt-5a signaling and dendritic spines in cultured hippocampal neurons.

  9. Here we show that an evolutionarily conserved genomic region named AS3_9 comprises three TEs (show TES Proteins) (AmnSINE1, X6b_DNA and MER117), inserted side-by-side, and functions as a distal enhancer for wnt5a expression during morphogenesis of the mammalian secondary palate.

  10. we here reported that Wnt5a mediated activation of canonical Wnt (show WNT2 Proteins) signaling pathway might contribute to the orthodontic force induced bone remodeling.

Xenopus laevis Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A) interaction partners

  1. Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2 (show ROR2 Proteins), which require Wnt5a/Ror2 (show ROR2 Proteins) signaling for their dedifferentiation accompanied by changes in cell morphology.

  2. Data show that PAPC (show PCDH8 Proteins) signaling via RhoA (show RHOA Proteins) and Wnt5a/Ror2 (show ROR2 Proteins) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.

  3. Data show that Rspo3 (show RSPO3 Proteins) binds syndecan 4 and that together they activate Wnt5a/PCP (show PRCP Proteins) signaling.

  4. In an examination of signaling pathways in developing Xenopus lung, wnt5a was expressed in the mesenchyme layer of the entire lungs through stages 39-41.

  5. Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4 (show SDC4 Proteins) in dorsal mesodermal cells from Xenopus gastrulae.

  6. Transcriptional regulation of XPAPC (show PCDH8 Proteins) by XWnt-5A requires the receptor tyrosine kinase Ror2 (show ROR2 Proteins).

  7. Xwnt-5a plays an instructive role in larval tail regeneration via Wnt (show WNT2 Proteins)/JNK (show MAPK8 Proteins) signaling

Human Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A) interaction partners

  1. RSPO2 (show RSPO2 Proteins) suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt (show WNT2 Proteins) pathway.

  2. High expression of WNT5A is associated with squamous cell lung carcinoma.

  3. Study shows that WNT5A stimulates dimerization of membrane-anchored FZD4 (show FZD4 Proteins) CRDs and oligomerization of full-length FZD4 (show FZD4 Proteins), which requires the integrity of CRD (show CRX Proteins) palmitoleoyl-binding residues. These results suggest that FZD receptors may form signalosomes in response to Wnt (show WNT2 Proteins) binding through the CRDs and that the Wnt (show WNT2 Proteins) palmitoleoyl group is important in promoting these interactions.

  4. Taken together with our previous findings, we have replicated our results from the rodent system in a novel human system. We have revealed a unique sequential cascade involving Atg10 (show ATG10 Proteins), Wnt5a, alpha1 integrin (show ITGA1 Proteins), and matrix metalloproteinase-3 (show MMP3 Proteins) in GS/BMP-4 (show BMP4 Proteins)-induced differentiation of hiPS cells into odontoblast-like cells at a relatively early stage.

  5. Elevated WNT5A expression in obesity may function as a negative regulator of angiogenesis.NEW & NOTEWORTHY Wingless-related integration site 5a (WNT5A) negatively regulates adipose tissue angiogenesis via VEGF-A165b in human obesity.

  6. Wnt5a as a master regulator of brain invasion, specifically tumor-promoting stem-like characteristics (TPC (show CCDC6 Proteins)), and they provide a therapeutic rationale to target it in patients with glioblastoma.

  7. inhibition of WNT-5A in vivo attenuated lung tissue destruction, improved lung function, and restored expression of beta-catenin (show CTNNB1 Proteins)-driven target genes and alveolar epithelial cell markers in the elastase, as well as in cigarette smoke induced models of COPD (show ARCN1 Proteins).

  8. Wnt5A/Ryk (show RYK Proteins) signaling might provide novel therapeutic strategies to prevent capillary leakage in systemic inflammation and septic shock.

  9. Profound vascular insulin (show INS Proteins) resistance in the visceral adipose tissue arterioles of obese subjects was associated with up-regulated WNT5A-JNK (show MAPK8 Proteins) signaling and impaired endothelial eNOS (show NOS3 Proteins) activation.

  10. Aberrant activation of WNT (show WNT2 Proteins) pathways in patients with ESRD significantly correlated with vascular calcification.

Cow (Bovine) Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A) interaction partners

  1. WNT5A is a negative regulator of FSH (show BRD2 Proteins)-stimulated granulosa cell steroidogenesis in cattle.

Rabbit Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A) interaction partners

  1. Wnt-5A may be associated with cartilage destruction by promoting the expression of matrix metalloproteinases.

WNT5A Protein Profile

Protein Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with WNT5A

  • wingless-type MMTV integration site family, member 5A (WNT5A)
  • wingless-type MMTV integration site family, member 5A (Wnt5a)
  • wingless-type MMTV integration site family, member 5A (wnt5a)
  • wingless-type MMTV integration site family, member 5a (wnt5a)
  • wingless-related MMTV integration site 5A (Wnt5a)
  • wingless-related MMTV integration site 5A (LOC578814)
  • Wnt signaling ligand (wnt5)
  • WNT-5A protein (WNT-5A)
  • 8030457G12Rik protein
  • hWNT5A protein
  • Wnt-5a protein
  • WNT5A protein
  • wnt5a-B protein

Protein level used designations for WNT5A

WNT-5A protein , protein Wnt-5a , Wnt-5a protein , wingless-related MMTV integration site 5A , wingless-type MMTV integration site 5A , XWnt-5a , Wnt-5a , wingless-type MMTV integration site family, member 5A , protein Wnt-5a-like , cell signaling molecule Wnt-5

7474 Homo sapiens
64566 Rattus norvegicus
378689 Xenopus laevis
395703 Gallus gallus
484721 Canis lupus familiaris
530005 Bos taurus
568191 Danio rerio
705692 Macaca mulatta
100401066 Callithrix jacchus
100447525 Pongo abelii
100012859 Monodelphis domestica
100602014 Nomascus leucogenys
22418 Mus musculus
578814 Strongylocentrotus purpuratus
445761 Ciona intestinalis
100009381 Oryctolagus cuniculus
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