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Human WNT5A Protein expressed in Wheat germ - ABIN1325364
Bazhin, Tambor, Dikov, Philippov, Schadendorf, Eichmüller: cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. in Cellular and molecular life sciences : CMLS 2010
There is an important role of Wnt5a in kidney development. Disrupted Wnt5a results in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.
Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours
Here we show that an evolutionarily conserved genomic region named AS3_9 comprises three TEs (show TES Proteins) (AmnSINE1, X6b_DNA and MER117), inserted side-by-side, and functions as a distal enhancer for wnt5a expression during morphogenesis of the mammalian secondary palate.
we here reported that Wnt5a mediated activation of canonical Wnt (show WNT2 Proteins) signaling pathway might contribute to the orthodontic force induced bone remodeling.
Wnt5a deficiency can regulate inflammatory cytokine secretion, polarization, and apoptosis in MTB (show NCAPG2 Proteins)-infected macrophage
These results showed that Wnt5a could promote the maturation of mast cells via the canonical Wnt (show WNT2 Proteins) signaling pathway and provide important insights into the molecular mechanisms underlying the differentiation of mast cells
the CaMKK (show CAMKK2 Proteins)-CaMKIalpha (show CAMK1 Proteins) cascade is required for the axonal growth effect of Wnt5a during neuronal polarization.
Decreased expressions of Wnt1 (show WNT1 Proteins) and Wnt5a.
indicate that restricted expression of Wnt5a in the caudal SpM (show NPC1 Proteins) is essential for normal OFT morphogenesis, and uncover a novel function of spatially regulated cell cohesion by Wnt5a in driving the deployment of SHF (show SHF Proteins) cells from the SpM (show NPC1 Proteins) into the OFT
Findings indicate wingless-related MMTV integration site 5A protein (WNT5a) as a key regulator of follicle development and gonadotropin responsiveness.
The oxidative stress of diabetes mellitus impairs Wnt (show WNT2 Proteins) signaling and causes cardiac outlet defects that are rescued by SOD1 (show SOD1 Proteins) overexpression
The results in a potent increase in odontoblastic cell differentiation, indicating the unique involvement of Atg5 (show ATG5 Proteins), autophagy and Wnt5 signaling in CS/BMP-4 (show BMP4 Proteins)-induced differentiation of ES cells into odontoblast-like cells, at a relatively early stage.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2 (show ROR2 Proteins), which require Wnt5a/Ror2 (show ROR2 Proteins) signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (show PCDH8 Proteins) signaling via RhoA (show RHOA Proteins) and Wnt5a/Ror2 (show ROR2 Proteins) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Data show that Rspo3 (show RSPO3 Proteins) binds syndecan 4 and that together they activate Wnt5a/PCP (show PRCP Proteins) signaling.
In an examination of signaling pathways in developing Xenopus lung, wnt5a was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4 (show SDC4 Proteins) in dorsal mesodermal cells from Xenopus gastrulae.
Transcriptional regulation of XPAPC (show PCDH8 Proteins) by XWnt-5A requires the receptor tyrosine kinase Ror2 (show ROR2 Proteins).
Xwnt-5a plays an instructive role in larval tail regeneration via Wnt (show WNT2 Proteins)/JNK (show MAPK8 Proteins) signaling
5-FU-induced tumor suppression (reduced cell viability) was reduced by WNT5A overexpression in hypermethylated HCT116 and SW620 cells and enhanced by WNT5A downregulation in unmethylated LoVo and SW480 cells.
Study established a glioblastoma model that affords a direct comparison of genome-wide histone modifications and associated gene expression alterations between parental human neural stem cells and their derivative oncogene (show RAB1A Proteins)-induced glioblastoma stem cells (iGSCs), identifying PAX6 (show PAX6 Proteins)- and DLX5 (show DLX5 Proteins)-regulated WNT5A as a key factor driving iGSCs differentiation into GSC (show GSC Proteins) differentiation into endothelial-like cells (GdECs).
Wnt5a protein expression might contribute to the tumor progression and poor prognosis of triple-negative breast cancer
we performed a rescue experiment in the JB6 cell line and found that the inhibitory effect of Wnt5a on cell proliferation could be rescued by the addition of Wnt3a. Our data reveal that Wnt5a suppresses the activation of b-catenin signaling during hair follicle regeneration.
Data show that MeCP2 (show MECP2 Proteins) promotes gastric cancer (GC) cell proliferation via FOXF1 (show FOXF1 Proteins)-mediated Wnt5a/beta-Catenin (show CTNNB1 Proteins) signaling pathway, and suppresses GC cell apoptosis through MYOD1 (show MYOD1 Proteins)-mediated Caspase-3 (show CASP3 Proteins) signaling pathway.
The Wnt5a signaling pathway promotes osteosarcoma metastasis; LDOC1 (show LDOC1 Proteins) expression decreased Wnt5a levels in osteosarcoma cells.
Conclusion. In articular cartilage, the expressions of OPN (show SPP1 Proteins) and Wnt5a are positively related to progressive damage of knee OA joint. The correlation between Wnt5a and OPN (show SPP1 Proteins) might be important to the progression and pathogenesis of knee OA.
Eosinophils enhance Wnt-5a, TGF-beta1 (show TGFB1 Proteins), fibronectin (show FN1 Proteins), and collagen gene expression in airway smooth muscle cells and promote proliferation of these cells in asthma.
86% of the ALL patients were hypermethylated in the WNT5A promoter region. Jurkat and RPMI cell lines were treated with 5'-aza-20-deoxycytidine and WNT5A mRNA expression was restored after treatment. Epigenetic changes of WNT (show WNT2 Proteins) signaling can play a role in ALL pathogenesis
In this study, we explored the Wnt-5a binding site and designed an antigenic epitope on the MUC18 (show MCAM Proteins) receptor using in silico methods. A specific single-chain variable fragment (scFv) was isolated against the epitope by several panning processes.The results suggest the specific anti-MUC18 (show MCAM Proteins) scFv as an effective antibody for breast cancer immunotherapy
WNT5A is a negative regulator of FSH (show BRD2 Proteins)-stimulated granulosa cell steroidogenesis in cattle.
Wnt-5A may be associated with cartilage destruction by promoting the expression of matrix metalloproteinases.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
wingless-type MMTV integration site family, member 5A
, protein Wnt-5a
, protein Wnt-5a-like
, WNT-5A protein
, Wnt-5a protein
, wingless-related MMTV integration site 5A
, wingless-type MMTV integration site 5A