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Human WNT5A Protein expressed in Wheat germ - ABIN1325364
Bazhin, Tambor, Dikov, Philippov, Schadendorf, Eichmüller: cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. in Cellular and molecular life sciences : CMLS 2010
There is an important role of Wnt5a in kidney development. Disrupted Wnt5a results in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.
Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours
Wnt5a deficiency can regulate inflammatory cytokine secretion, polarization, and apoptosis in MTB (show NCAPG2 Proteins)-infected macrophage
These results showed that Wnt5a could promote the maturation of mast cells via the canonical Wnt (show WNT2 Proteins) signaling pathway and provide important insights into the molecular mechanisms underlying the differentiation of mast cells
the CaMKK (show CAMKK2 Proteins)-CaMKIalpha (show CAMK1 Proteins) cascade is required for the axonal growth effect of Wnt5a during neuronal polarization.
Decreased expressions of Wnt1 (show WNT1 Proteins) and Wnt5a.
indicate that restricted expression of Wnt5a in the caudal SpM (show NPC1 Proteins) is essential for normal OFT morphogenesis, and uncover a novel function of spatially regulated cell cohesion by Wnt5a in driving the deployment of SHF (show SHF Proteins) cells from the SpM (show NPC1 Proteins) into the OFT
Findings indicate wingless-related MMTV integration site 5A protein (WNT5a) as a key regulator of follicle development and gonadotropin responsiveness.
The oxidative stress of diabetes mellitus impairs Wnt (show WNT2 Proteins) signaling and causes cardiac outlet defects that are rescued by SOD1 (show SOD1 Proteins) overexpression
The results in a potent increase in odontoblastic cell differentiation, indicating the unique involvement of Atg5 (show ATG5 Proteins), autophagy and Wnt5 signaling in CS/BMP-4 (show BMP4 Proteins)-induced differentiation of ES cells into odontoblast-like cells, at a relatively early stage.
the Wnt5a/Frizzled-2 (show FZD2 Proteins) axis suppresses beta-catenin (show CTNNB1 Proteins) signaling in hepatocytes in an autocrine manner, thereby contributing to timely conclusion of the liver regeneration process
effects on hypoxic pulmonary hypertension by regulating pulmonary vascular remodeling and right ventricular hypertrophy via reduction in beta-catenin (show CTNNB1 Proteins)/cyclin D1 (show CCND1 Proteins) signaling
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2 (show ROR2 Proteins), which require Wnt5a/Ror2 (show ROR2 Proteins) signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (show PCDH8 Proteins) signaling via RhoA (show RHOA Proteins) and Wnt5a/Ror2 (show ROR2 Proteins) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Data show that Rspo3 (show RSPO3 Proteins) binds syndecan 4 and that together they activate Wnt5a/PCP (show PRCP Proteins) signaling.
In an examination of signaling pathways in developing Xenopus lung, wnt5a was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4 (show SDC4 Proteins) in dorsal mesodermal cells from Xenopus gastrulae.
Transcriptional regulation of XPAPC (show PCDH8 Proteins) by XWnt-5A requires the receptor tyrosine kinase Ror2 (show ROR2 Proteins).
Xwnt-5a plays an instructive role in larval tail regeneration via Wnt (show WNT2 Proteins)/JNK (show MAPK8 Proteins) signaling
Eosinophils enhance Wnt-5a, TGF-beta1 (show TGFB1 Proteins), fibronectin (show FN1 Proteins), and collagen gene expression in airway smooth muscle cells and promote proliferation of these cells in asthma.
86% of the ALL patients were hypermethylated in the WNT5A promoter region. Jurkat and RPMI cell lines were treated with 5'-aza-20-deoxycytidine and WNT5A mRNA expression was restored after treatment. Epigenetic changes of WNT (show WNT2 Proteins) signaling can play a role in ALL pathogenesis
In this study, we explored the Wnt-5a binding site and designed an antigenic epitope on the MUC18 (show MCAM Proteins) receptor using in silico methods. A specific single-chain variable fragment (scFv) was isolated against the epitope by several panning processes.The results suggest the specific anti-MUC18 (show MCAM Proteins) scFv as an effective antibody for breast cancer immunotherapy
silencing of CerS6 (show CERS6 Proteins) induced the increased expression of GLUT1 (show SLC2A1 Proteins), which downregulated the expression of WNT5A and enhanced the invasion and proliferation of melanoma cells.
Study revealed a previously unrecognized immunomodulatory role of endogenous Wnt5A in ovarian cancer cells, which could further influence chemotactic cell migration.
Wnt5a is involved in the modulation of pancreatic cancer cell proliferation.
these findings suggest that miR154 functions as a tumor suppressor in osteosarcoma by partially suppressing Wnt5a expression.
Studied the roles of WNT4 (show WNT4 Proteins) and WNT5A in human decidulization and their relationship with preeclampsia.
High WNT5A and WNT5B expression strongly associates with unmutated IGHV.
Wnt5a is increased and beta-catenin (show CTNNB1 Proteins) is decreased in parenchyma from idiopathic pulmonary fibrosis patients.
WNT5A is a negative regulator of FSH (show BRD2 Proteins)-stimulated granulosa cell steroidogenesis in cattle.
Wnt-5A may be associated with cartilage destruction by promoting the expression of matrix metalloproteinases.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
wingless-type MMTV integration site family, member 5A
, protein Wnt-5a
, protein Wnt-5a-like
, WNT-5A protein
, Wnt-5a protein
, wingless-related MMTV integration site 5A
, wingless-type MMTV integration site 5A