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Human WNT5A Protein expressed in Wheat germ - ABIN1325364
Bazhin, Tambor, Dikov, Philippov, Schadendorf, Eichmüller: cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. in Cellular and molecular life sciences : CMLS 2010
There is an important role of Wnt5a in kidney development. Disrupted Wnt5a results in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.
Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours
Decreased expressions of Wnt1 (show WNT1 Proteins) and Wnt5a.
indicate that restricted expression of Wnt5a in the caudal SpM (show NPC1 Proteins) is essential for normal OFT morphogenesis, and uncover a novel function of spatially regulated cell cohesion by Wnt5a in driving the deployment of SHF (show SHF Proteins) cells from the SpM (show NPC1 Proteins) into the OFT
Findings indicate wingless-related MMTV integration site 5A protein (WNT5a) as a key regulator of follicle development and gonadotropin responsiveness.
The oxidative stress of diabetes mellitus impairs Wnt (show WNT2 Proteins) signaling and causes cardiac outlet defects that are rescued by SOD1 (show SOD1 Proteins) overexpression
The results in a potent increase in odontoblastic cell differentiation, indicating the unique involvement of Atg5 (show ATG5 Proteins), autophagy and Wnt5 signaling in CS/BMP-4 (show BMP4 Proteins)-induced differentiation of ES cells into odontoblast-like cells, at a relatively early stage.
the Wnt5a/Frizzled-2 (show FZD2 Proteins) axis suppresses beta-catenin (show CTNNB1 Proteins) signaling in hepatocytes in an autocrine manner, thereby contributing to timely conclusion of the liver regeneration process
effects on hypoxic pulmonary hypertension by regulating pulmonary vascular remodeling and right ventricular hypertrophy via reduction in beta-catenin (show CTNNB1 Proteins)/cyclin D1 (show CCND1 Proteins) signaling
Wnt5a regulates the pathogenesis of gp120 (show ITIH4 Proteins)-induced pain.
Study identified a novel Wnt5a/Fzd4 (show FZD4 Proteins) signaling pathway that contributes to the regulation of dendrite morphogenesis
The Wnt5a-Ror2 (show ROR2 Proteins) axis promotes the signaling circuit between interleukin-12 and interferon-gamma (show IFNG Proteins) in colitis
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2 (show ROR2 Proteins), which require Wnt5a/Ror2 (show ROR2 Proteins) signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (show PCDH8 Proteins) signaling via RhoA (show RHOA Proteins) and Wnt5a/Ror2 (show ROR2 Proteins) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Data show that Rspo3 (show RSPO3 Proteins) binds syndecan 4 and that together they activate Wnt5a/PCP (show PRCP Proteins) signaling.
In an examination of signaling pathways in developing Xenopus lung, wnt5a was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4 (show SDC4 Proteins) in dorsal mesodermal cells from Xenopus gastrulae.
Transcriptional regulation of XPAPC (show PCDH8 Proteins) by XWnt-5A requires the receptor tyrosine kinase Ror2 (show ROR2 Proteins).
Xwnt-5a plays an instructive role in larval tail regeneration via Wnt (show WNT2 Proteins)/JNK (show MAPK8 Proteins) signaling
Wnt5a is increased and beta-catenin (show CTNNB1 Proteins) is decreased in parenchyma from idiopathic pulmonary fibrosis patients.
results corroborated previous findings of Ryk (show RYK Proteins)-mediated Wnt5a effect, and suggested a role for Ror2 (show ROR2 Proteins) in the Wnt5a machinery in glioblastoma
WNT5A participates in the biology of odontogenic tumors and inflammatory cyst but not in developmental cyst.
Mutation in WNT5A may serve as a susceptibility factor for Congenital Anomalies Of Kidney And Urinary Tract.
Wnt5a-Ror2 (show ROR2 Proteins) signaling enhances expression and secretion of CXCL16 (show CXCL16 Proteins) in mesenchymal stem cells thereby activating CXCR6 (show CXCR6 Proteins) expressed on tumor cells to promote proliferation.
The homozygous genotypes (CC for rs524153 and GG for rs504849) were associated with a lower WNT5A transcriptional level compared with the transcriptional level of those with wild-type genotypes.
Epigenetic inactivation of the WNT5A promoter B involves both DNA methylation (show HELLS Proteins) and histone modifications. Differential expression of the WNT5A alternative promoters A and B is a characteristic of osteosarcomas.
Findings suggest that high receptor tyrosine kinase (show RET Proteins)-like orphan receptor (show NR1D2 Proteins) (ROR) 2 (show ROR2 Proteins) or proto-oncogene (show RAB1A Proteins) protein Wnt-5A (Wnt5a) expression is associated with poor prognosis in non-small cell lung cancer (NSCLC).
Noncanonical Wnt5a signaling and JNK (show MAPK8 Proteins) activity contribute to vascular insulin (show INS Proteins) resistance and endothelial dysfunction.
This study identifies an interaction between ROR1 (show ROR1 Proteins) and ROR2 (show ROR2 Proteins) that is required for Wnt5a signaling that promotes leukemia chemotaxis and proliferation.
WNT5A is a negative regulator of FSH (show BRD2 Proteins)-stimulated granulosa cell steroidogenesis in cattle.
Wnt-5A may be associated with cartilage destruction by promoting the expression of matrix metalloproteinases.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
wingless-type MMTV integration site family, member 5A
, protein Wnt-5a
, protein Wnt-5a-like
, WNT-5A protein
, Wnt-5a protein
, wingless-related MMTV integration site 5A
, wingless-type MMTV integration site 5A