Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human WNT5A Protein expressed in Wheat germ - ABIN1325364
Bazhin, Tambor, Dikov, Philippov, Schadendorf, Eichmüller: cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells. in Cellular and molecular life sciences : CMLS 2010
high miR (show MLXIP Proteins)-154 expression suppressed glioblastoma cell migration, invasion, and EMT (show ITK Proteins) development through targeting Wnt5a.
Wnt5a suppressed osteoblastic differentiation through Ror2 (show ROR2 Proteins)/JNK (show MAPK8 Proteins) signaling in periodontal ligament stem cell-like cells.
Genetic blockade of autophagy indicated an unexpected feedback loop whereby knocking down the autophagy factor ATG5 (show ATG5 Proteins) in Wnt5A(high) cells decreased Wnt5A and increased beta-catenin (show CTNNB1 Proteins).
Low WNT5A expression is associated with prostate cancer.
WNT5A signaling regulates 15-PGDH (show HPGD Proteins) expression.
our study showed that, for the first time, different Wnt5a mRNA isoforms play distinct roles in colorectal cancer (CRC (show CALR Proteins)) and can be used as novel prognostic markers for CRC (show CALR Proteins) in the future.
High WNT5a expression is associated with osteoarthritis.
We conclude that in RS, WNT5A missense mutations have dominant neomorphic effects that interfere with the function of the wild-type protein.
RSPO2 (show RSPO2 Proteins) suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt (show WNT2 Proteins) pathway.
High expression of WNT5A is associated with squamous cell lung carcinoma.
In midgastrula embryos, Wnt5a, Wnt11, and Wnt11b, but not Wnt3a (show WNT3A Proteins), acted across many cell diameters to orient Prickle3 (show PRICKLE3 Proteins)/Vangl2 complexes away from their sources regardless of their positions relative to the body axis.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2 (show ROR2 Proteins), which require Wnt5a/Ror2 (show ROR2 Proteins) signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (show PCDH8 Proteins) signaling via RhoA (show RHOA Proteins) and Wnt5a/Ror2 (show ROR2 Proteins) activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Data show that Rspo3 (show RSPO3 Proteins) binds syndecan 4 and that together they activate Wnt5a/PCP (show PRCP Proteins) signaling.
In an examination of signaling pathways in developing Xenopus lung, wnt5a was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Wnt5a reduces cell surface levels and promotes ubiquitination and degradation of SDC4 (show SDC4 Proteins) in dorsal mesodermal cells from Xenopus gastrulae.
Transcriptional regulation of XPAPC (show PCDH8 Proteins) by XWnt-5A requires the receptor tyrosine kinase Ror2 (show ROR2 Proteins).
Xwnt-5a plays an instructive role in larval tail regeneration via Wnt (show WNT2 Proteins)/JNK (show MAPK8 Proteins) signaling
WNT5A is a negative regulator of FSH (show BRD2 Proteins)-stimulated granulosa cell steroidogenesis in cattle.
There is an important role of Wnt5a in kidney development. Disrupted Wnt5a results in kidney cysts in zebrafish and pleiotropic abnormal kidney development in mice.
Wnt5a acts as a chemoattractant in the emerging limb bud where it contributes to the establishment of cell polarity that is likely to underlie the oriented cell behaviours
Wnt-5a activates NLK (Nemo-like kinase (show NLK Proteins)), which then phosphorylates a histone methyltransferase, SETDB1 (SET domain bifurcated 1 (show SETDB1 Proteins)), leading to the formation of a co-repressor complex that inactivates PPAR-gamma (show PPARG Proteins) function through histone H3 (show HIST3H3 Proteins)-K9 methylation.
results indicate that Wnt5a signaling restricts infection by antimony drug-sensitive and -resistant Leishmania donovani strains, at least in part by prohibiting parasite niche formation within host macrophages
During mouse embryonic stem cell (ESC) in vitro osteogenesis, the noncanonical WNT5a is expressed early on.
This study shows that Wnt5a is not required for development of the renal medulla and that loss of the renal medullary region in the Wnt5a-deleted kidney is caused by an abnormal ureter-bladder connection.
WNT5A in the bone marrow niche is required to regenerate hematopoietic stem cells and leukemic cells with functional ability to rearrange the actin cytoskeleton and engraft successfully.
This study describes the localization and functional role of WNT-5A in human and mouse fibrotic livers. Hepatic WNT-5A expression parallels collagen type I expression. In vivo and in vitro, the myofibroblasts were identified as the key hepatic cells producing WNT-5A. WNT-5A is under control of TGF-beta (show TGFB1 Proteins) and its activities are primarily profibrotic.
we confirmed the requirement of Wnt5a in the deferoxamine-mediated osteoblast-promoting effects by analyzing the matrix mineralization of Wnt5a-deficient cells. The promoting effect of deferoxamine on matrix mineralization in wild-type cells was completely abolished in Wnt5a(-/-) cells.
opposing gradients of Wnt5a and Wnt5b (show WNT5B Proteins) and of their Sfrp inhibitors, together with intercellular signaling via planar cell polarity proteins, polarize node cells along the anterior-posterior axis for breaking of left-right symmetry.
Wnt5a is responsible for maintaining effective communication between the stromal and epithelial compartments partly through the action of luminal and stromal secreted factors, Fgf10 (show FGF10 Proteins) and Ihh (show IHH Proteins).
findings reveal that FZD9 and heterotrimeric G proteins regulate Wnt-5a signaling and dendritic spines in cultured hippocampal neurons.
Wnt-5A may be associated with cartilage destruction by promoting the expression of matrix metalloproteinases.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
, protein Wnt-5a
, Wnt-5a protein
, wingless-related MMTV integration site 5A
, wingless-type MMTV integration site 5A
, wingless-type MMTV integration site family, member 5A
, protein Wnt-5a-like
, cell signaling molecule Wnt-5