Biotin-Protein Ligase Proteins (HLCS)

HLCS encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. Additionally we are shipping Biotin-Protein Ligase Antibodies (29) and Biotin-Protein Ligase Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HLCS 110948 Q920N2
HLCS 3141 P50747
Rat HLCS HLCS 288240  
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Top Biotin-Protein Ligase Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

HLCS Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for Biotin-Protein Ligase (HLCS) Interaction Partners

Human Biotin-Protein Ligase (HLCS) interaction partners

  1. The function of HCS and biotin in metabolism and human disease, a putative role for the enzyme in histone biotinylation, and its participation as a nuclear factor in chromatin dynamics is discussed.

  2. The transcriptional function of HCS was shown by in vitro pull down and in vivo co-immunoprecipitation assays to depend on its interaction with the histone deacetylases HDAC1 (show HDAC1 Proteins), HDAC2 (show HDAC2 Proteins) and HDAC7 (show HDAC7 Proteins)

  3. Data suggest that direct interactions of HLCS (holocarboxylase synthetase) with NCOR1 (nuclear receptor corepressor 1 (show NCOR1 Proteins)) and HDAC1 (histone deacetylase 1 (show HDAC1 Proteins)) contribute toward transcriptional repression of repeats, presumably increasing genome stability.

  4. study characterizes three functional promoters in the human HLCS gene

  5. HLCS interacts physically with the DNA methyltransferase (show DNMT1 Proteins) DNMT1 (show DNMT1 Proteins) and the methyl CpG binding protein MeCP2 to facilitate the binding of HLCS to chromatin.

  6. This study showed that modification of HSP72 (show HSPA1A Proteins) and demonstrated that binding of biotin to extracellular HSP72 (show HSPA1A Proteins) prepares cells for a strong immune response.

  7. individuals with HLCS SNPs may benefit from supplemental biotin, yet to different extents depending on the genotype

  8. HLCS methionine-58 is a functional translation start site in human cells.

  9. Holocarboxylase synthetase interacts directly with histone H3 (show HIST3H3 Proteins), causing biotinylation of lysine K9 and K18 (show KRT18 Proteins).

  10. Mutation analysis by polymerase chain reaction-sequencing of the entire coding region of the HLCS gene revealed the c.1522C>T (p.R508W) mutation in six of the eight mutant alleles. suggests it as the most common mutation in the Thai population

Biotin-Protein Ligase (HLCS) Protein Profile

Protein Summary

This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with Biotin-Protein Ligase Proteins (HLCS)

  • holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) (Hlcs)
  • holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) (HLCS)
  • holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) (Hlcs)
  • 410I21.SP6 protein
  • D16Jhu34 protein
  • HCS protein
  • RGD1565360 protein

Protein level used designations for Biotin-Protein Ligase Proteins (HLCS)

biotin apo-protein ligase , biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase , biotin--protein ligase , biotin--[acetyl-CoA-carboxylase] ligase , biotin--[methylcrotonoyl-CoA-carboxylase] ligase , biotin--[methylmalonyl-CoA-carboxytransferase] ligase , holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase) , holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)

110948 Mus musculus
3141 Homo sapiens
288240 Rattus norvegicus
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