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Breakpoint Cluster Region Proteins (BCR)

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. Additionally we are shipping BCR Antibodies (147) and BCR Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BCR 613 P11274
BCR 110279 Q6PAJ1
Rat BCR BCR 309696  
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Top BCR Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

BCR Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine)

More Proteins for Breakpoint Cluster Region (BCR) Interaction Partners

Human Breakpoint Cluster Region (BCR) interaction partners

  1. demonstrated that depletion of endogenous MAPK15 (show MAPK15 Proteins) expression inhibited BCR-ABL1 (show ABL1 Proteins)-dependent cell proliferation

  2. Identify a novel BCR-ABL (show ABL1 Proteins)/IkappaBalpha (show NFKBIA Proteins)/p53 (show TP53 Proteins) network, whereby BCR-ABL (show ABL1 Proteins) functionally inactivates a key tumor suppressor in chronic myeloid leukemia (show BCL11A Proteins).

  3. Blockade of the interaction between Bcr-Abl and PTB1B by small molecule SBF-1 to overcomes imatinib-resistance of K562 cells.

  4. BCR-ABL1 transcript types found in Syria were similar to that of Indian Far-Eastern, African or European populations. The M-BCR rearrangement types were not dependent on white blood count, platelet count, hemoglobin level or gender of the patients.

  5. Data suggest elevated interleukin-1beta secretion from tyrosine kinase (show TXK Proteins) inhibitor- (TKI-)resistant chronic myeloid leukemia (show BCL11A Proteins) (CML) cells contributes to TKI/imatinib resistance via promotion of cell viability/migration; cells used lack BCR-ABL (show ABL1 Proteins) mutation.

  6. Higher incidence of BCR-ABL and lower incidence of TEL-AML1 are associated with acute lymphoblastic leukemia.

  7. Suggest that AIC-47 in combination with imatinib strengthened the attack on cancer energy metabolism in BCR-ABL (show ABL1 Proteins)-harboring leukemic cells.

  8. Molecular rearrangements and the minimal residual disease follow-up for 5 chronic myeloid leukaemia patients; 3 resulted from new rearrangements between the BCR and ABL1 (show ABL1 Proteins) sequences (the breakpoints being located within BCR exon 13 in 2 cases and within BCR exon 18 in one case). The other 2 cases revealed a complex e8-[ins (show INS Proteins)]-a2 fusion transcript involving a 3rd partner gene.

  9. analysis of WT1 and M-BCR-ABL expressions in chronic myeloid leukemia reveals that high WT1 expression in CML patients is detected especially in the advanced stages of the disease

  10. BCR-ABL kinase domain mutation is associated with Philadelphia-positive leukemia.

Mouse (Murine) Breakpoint Cluster Region (BCR) interaction partners

  1. The resistance in BCR-ABL1 (show ABL1 Proteins) cells resulted either from the Y253H mutation in the BCR-ABL1 (show ABL1 Proteins) gene or incubation in increasing concentrations of imatinib.

  2. PDZK1 (show PDZK1 Proteins) has novel SR-BI (show SCARB1 Proteins)-independent function in VSM that affords protection from neointima formation, and this involves PDZK1 (show PDZK1 Proteins) suppression of VSM cell proliferation via an inhibitory interaction with Bcr

  3. Hap1 (show HAP1 Proteins) interacts with Bcr on microtubules to regulate neuronal differentiation.

  4. Grb10 (show GRB10 Proteins) is involved in BCR-ABL (show ABL1 Proteins)-positive leukemia in mice.

  5. Bcr is an integral member of the Par (show AFG3L2 Proteins)-Tiam1 (show TIAM1 Proteins) complex that controls polarized cell migration by locally restricting both Rac1 and PKCzeta (show PRKCZ Proteins) function.

  6. Loss of Bcr expression causes defects in spine development.

  7. Suggest that HS-438 may be a novel drug candidate with the therapeutic potential to target BCR-ABL (show ABL1 Proteins) and overcome imatinib resistance in patients with chronic myeloid leukemia (show BCL11A Proteins).

  8. IRF8 (show IRF8 Proteins)-rescued BCR-ABL (show ABL1 Proteins)-expressing dendritic cells were capable of inducing CTLs more efficiently than control dendritic cells.

  9. study provided evidence for a novel, BCR-ABL (show ABL1 Proteins)-mediated antiapoptotic mechanism, which results from the increased acetylation of p53 (show TP53 Proteins) at the K317/K320 residue, thus preventing the nuclear export of p53 (show TP53 Proteins) in response to DNA damage.

  10. Intrafemoral transplantation of BCR-ABL-transduced Cbl-b(-/-) cells revealed equivalent latency of disease development to the wild-type transplants

BCR Protein Profile

Protein Summary

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with BCR

  • breakpoint cluster region (bcr)
  • breakpoint cluster region (BCR)
  • breakpoint cluster region (Bcr)
  • 5133400C09Rik protein
  • AI561783 protein
  • AI853148 protein
  • ALL protein
  • BCR protein
  • BCR1 protein
  • CML protein
  • D22S11 protein
  • D22S662 protein
  • mKIAA3017 protein
  • PHL protein
  • si:dkey-83d9.7 protein
  • zK83D9.7 protein

Protein level used designations for BCR

breakpoint cluster region , breakpoint cluster region protein-like , BCR/FGFR1 chimera protein , FGFR1/BCR chimera protein , breakpoint cluster region protein , renal carcinoma antigen NY-REN-26 , breakpoint cluster region homolog

568320 Danio rerio
100393591 Callithrix jacchus
100431481 Pongo abelii
458694 Pan troglodytes
100554393 Anolis carolinensis
613 Homo sapiens
110279 Mus musculus
309696 Rattus norvegicus
100157974 Sus scrofa
100718992 Cavia porcellus
416952 Gallus gallus
607482 Canis lupus familiaris
789892 Bos taurus
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