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BCR Products

(Breakpoint Cluster Region (BCR))

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A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured BCR Categories

BCR Antibodies

High quality antibodies with extensive validation data.

BCR ELISA Kits

Reliable ELISA kits for a wide range of species.

BCR Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended BCR Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, FACS, ICC, Neut
Validations
  • (5)
Cat. No. ABIN5611129
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, PLA
Validations
  • (5)
Cat. No. ABIN513693
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (4)
Cat. No. ABIN6256715
Quantity 100 μL
Datasheet Datasheet

Recommended BCR ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380534
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380340
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN418035
Quantity 96 tests
Datasheet Datasheet

Recommended BCR Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346603
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7505420
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7418029
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our BCR products

Bruynzeel, Abou El Hassan, Schalkwijk, Berkhof, Bast, Niessen, van der Vijgh: "Anti-inflammatory agents and monoHER protect against DOX-induced cardiotoxicity and accumulation of CML in mice." in: British journal of cancer, Vol. 96, Issue 6, pp. 937-43, (2007) (PubMed).

Ciapaite, Bakker, Van Eikenhorst, Wagner, Teerlink, Schalkwijk, Fodor, Ouwens, Diamant, Heine, Westerhoff, Krab: "Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats." in: Biochimica et biophysica acta, Vol. 1772, Issue 3, pp. 307-16, (2007) (PubMed).

Baidoshvili, Krijnen, Kupreishvili, Ciurana, Bleeker, Nijmeijer, Visser, Visser, Meijer, Stooker, Eijsman, van Hinsbergh, Hack, Niessen, Schalkwijk: "N(epsilon)-(carboxymethyl)lysine depositions in intramyocardial blood vessels in human and rat acute myocardial infarction: a predictor or reflection of infarction?" in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 26, Issue 11, pp. 2497-503, (2006) (PubMed).

van Heijst, Niessen, Musters, van Hinsbergh, Hoekman, Schalkwijk: "Argpyrimidine-modified Heat shock protein 27 in human non-small cell lung cancer: a possible mechanism for evasion of apoptosis." in: Cancer letters, Vol. 241, Issue 2, pp. 309-19, (2006) (PubMed).

Burchert, Cai, Hofbauer, Samuelsson, Slater, Duyster, Ritter, Hochhaus, Müller, Eilers, Schmidt, Neubauer: "Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2." in: Blood, Vol. 103, Issue 9, pp. 3480-9, (2004) (PubMed).

Salesse, Dylla, Verfaillie: "p210BCR/ABL-induced alteration of pre-mRNA splicing in primary human CD34+ hematopoietic progenitor cells." in: Leukemia, Vol. 18, Issue 4, pp. 727-33, (2004) (PubMed).

Million, Harakawa, Roumiantsev, Varticovski, Van Etten: "A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase." in: Molecular and cellular biology, Vol. 24, Issue 11, pp. 4685-95, (2004) (PubMed).

Håkansson, Segal, Lassen, Gullberg, Morse, Fioretos, Meltzer: "Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays." in: Experimental hematology, Vol. 32, Issue 5, pp. 476-82, (2004) (PubMed).

Sommeijer, Beganovic, Schalkwijk, Ploegmakers, van der Loos, van Aken, ten Cate, van der Wal: "More fibrosis and thrombotic complications but similar expression patterns of markers for coagulation and inflammation in symptomatic plaques from DM2 patients." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 52, Issue 9, pp. 1141-9, (2004) (PubMed).

Li, Couvillon, Brasher, Van Etten: "Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling." in: The EMBO journal, Vol. 20, Issue 23, pp. 6793-804, (2001) (PubMed).

Synonyms and alternative names related to BCR

breakpoint cluster region (bcr), BCR, RhoGEF and GTPase activating protein (BCR), BCR, RhoGEF and GTPase activating protein (bcr), breakpoint cluster region (Bcr), BCR, RhoGEF and GTPase activating protein (Bcr), 5133400C09Rik, AI561783, AI853148, ALL, BCR, BCR1, CML, D22S11, D22S662, mKIAA3017, PHL, si:dkey-83d9.7, zK83D9.7

Protein level used designations for BCR

  • breakpoint cluster region
  • breakpoint cluster region protein-like
  • BCR/FGFR1 chimera protein
  • FGFR1/BCR chimera protein
  • breakpoint cluster region protein
  • renal carcinoma antigen NY-REN-26
  • breakpoint cluster region homolog
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