Butyrophilin-Like 2 (MHC Class II Associated) Proteins (BTNL2)

Negative regulator of T-cell proliferation.. Additionally we are shipping BTNL2 Antibodies (7) and BTNL2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BTNL2 547431 O70355
BTNL2 56244 Q9UIR0
Rat BTNL2 BTNL2 309620  
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Top BTNL2 Proteins at antibodies-online.com

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
HOST_Human Mouse His tag   10 μg Log in to see 4 Days

BTNL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

More Proteins for Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2) Interaction Partners

Mouse (Murine) Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2) interaction partners

  1. Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3 (show FOXP3 Proteins) expression and regulatory T cell development in mature T cells.

  2. BTNL2 is overexpressed during both the asymptomatic and symptomatic phase of the Mdr1a (show ABCB4 Proteins) knockout model of spontaneous colitis. Soluble BTNL2-Fc protein inhibits proliferation of murine T4 cells from the spleen, mesenteric lymph node, and Peyer's patch.

Human Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2) interaction partners

  1. Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR (show EGFR Proteins) mutations. In further sub-analyses by EGFR (show EGFR Proteins) status, rs9387478 (ROS1 (show ROS1 Proteins)/DCBLD1) and rs2179920 (HLA-DPB1 (show HLA-DPB1 Proteins)) showed stronger estimated associations in EGFR (show EGFR Proteins)-positive compared to EGFR (show EGFR Proteins)-negative cases

  2. BTNL2 variant is associated with psoriasis.

  3. Butyrophilin-like 2, expressed at various levels by UM cells and macrophages, might interfere with the immune control of the tumor. Butyrophilin-like 2 variants showed highly variable frequencies among ethnically related cohorts. There was no enrichment of BTNL2 variants in patients with UM compared with control patients.

  4. BTNL2 G16071A gene polymorphism may as a likelihood factor contributed to granulomatous disease susceptibility, especially increasing the sarcoidosis susceptibility. In addition, the polymorphism may be greatly associated with likelihood of granulomatous diseases among Caucasians.

  5. BTNL2 may have an inhibitory effect on FOXP3 (show FOXP3 Proteins)(+) T cell proliferation, especially in patients homozygous for the risk alleles.

  6. genetic mutations within or around BTNL2 (rs3763313, rs9268494, rs9268492 and rs9268402) could alter susceptibility to grade IV of dilated cardiomyopathy in a Chinese population

  7. Results confirm the association of BTNL2 rs2076530SNP with the susceptibility to develop sarcoidosis, but not with an increased risk of cancer in these patients.

  8. BTNL2 rs2076530 polymorphism contributes to the risk of sarcoidosis

  9. Two independent loci near BTNL2 (rs9461741) and HLA-B (rs2922994) in the HLA region significantly associated with Marginal Zone B-Cell Lymphoma risk.

  10. The association of the rare variant p.G454C in BTNL2 reached genome-wide significance, and was independent of the known common risk variants for IBD in the HLA region in both a conditional and haplotype analysis

BTNL2 Protein Profile

Protein Summary

Negative regulator of T-cell proliferation.

Gene names and symbols associated with BTNL2

  • butyrophilin-like 2 (MHC class II associated) (BTNL2)
  • butyrophilin-like 2 (Btnl2)
  • butyrophilin-like 2 (MHC class II associated) (Btnl2)
  • BTL-II protein
  • Btl2 protein
  • BTLN2 protein
  • BTNL2 protein
  • Gm315 protein
  • HSBLMHC1 protein
  • Ng9 protein
  • SS2 protein

Protein level used designations for BTNL2

butyrophilin-like protein 2 , butyrophilin-like 2 (MHC class II associated) , butyrophilin-like protein 2-like , butyrophylin-like MHC class II associated

481730 Canis lupus familiaris
789224 Bos taurus
505077 Bos taurus
745506 Pan troglodytes
100051881 Equus caballus
100158014 Sus scrofa
100348151 Oryctolagus cuniculus
100441854 Pongo abelii
547431 Mus musculus
56244 Homo sapiens
309620 Rattus norvegicus
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