BTNL2 Protein (AA 26-457) (Fc Tag)
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- Target See all BTNL2 Proteins
- BTNL2 (Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 26-457
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Origin
- Mouse
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Source
- CHO Cells
- Purification tag / Conjugate
- This BTNL2 protein is labelled with Fc Tag.
- Purpose
- BTNL2 (mouse):Fc (mouse) (rec.)
- Specificity
- The extracellular domain of mouse BTNL2 (aa 26-457) is fused to the N-terminus of the Fc region of mouse IgG2a.
- Characteristics
- Protein. The extracellular domain of mouse BTNL2 (aa 26-457) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis, to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.
- Purity
- >98 % (SDS-PAGE)
- Endotoxin Level
- <0.06EU/μg protein (LAL test, Lonza).
- Biological Activity Comment
- A butyrophilin-like molecule that functions to inhibit T cell activation.
- Top Product
- Discover our top product BTNL2 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Handling Advice
- Avoid freeze/thaw cycles.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Target
- BTNL2 (Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2))
- Alternative Name
- BTNL2 (BTNL2 Products)
- Synonyms
- BTL-II Protein, HSBLMHC1 Protein, SS2 Protein, Ng9 Protein, BTLN2 Protein, Btl2 Protein, Gm315 Protein, NG9 Protein, BTNL2 Protein, butyrophilin like 2 Protein, butyrophilin-like 2 Protein, butyrophilin-like 2 (MHC class II associated) Protein, butyrophilin-like protein 2 Protein, BTNL2 Protein, Btnl2 Protein, LOC100348151 Protein
- Background
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Alternate Names/Synonyms: Butyrophilin-like Protein 2
Product Description: Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis, to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.
- NCBI Accession
- NP_524574
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