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Chemokine (C-C Motif) Ligand 21 Proteins (CCL21)

CCL21 is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Additionally we are shipping CCL21 Antibodies (159) and CCL21 Kits (44) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCL21 6366 O00585
CCL21 65956 P86792 , P86793
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Top CCL21 Proteins at

Showing 10 out of 56 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human Un-conjugated 50 μg Log in to see 16 Days
HOST_Baculovirus infected Insect Cells Cynomolgus Un-conjugated 50 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 100 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days

CCL21 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine)
Rat (Rattus)

Top referenced CCL21 Proteins

  1. Human CCL21 Protein expressed in Baculovirus infected Insect Cells - ABIN2002927 : Christopherson, Campbell, Hromas: Transgenic overexpression of the CC chemokine CCL21 disrupts T-cell migration. in Blood 2001 (PubMed)
    Show all 3 references for ABIN2002927

  2. Human CCL21 Protein expressed in Escherichia coli (E. coli) - ABIN2666610 : Hedrick, Zlotnik: Identification and characterization of a novel beta chemokine containing six conserved cysteines. in Journal of immunology (Baltimore, Md. : 1950) 1997 (PubMed)
    Show all 3 references for ABIN2666610

  3. Cynomolgus CCL21 Protein expressed in Baculovirus infected Insect Cells - ABIN2009910 : Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ... in Genome research 2003 (PubMed)
    Show all 2 references for ABIN2009910

More Proteins for Chemokine (C-C Motif) Ligand 21 (CCL21) Interaction Partners

Human Chemokine (C-C Motif) Ligand 21 (CCL21) interaction partners

  1. CCL21 can facilitate chemoresistance and stem cell property of colorectal cancer cells via the upregulation of P-gp (show ABCB4 Proteins), Bmi-1 (show BMI1 Proteins), Nanog (show NANOG Proteins), and OCT-4 (show POU5F1 Proteins) through AKT (show AKT1 Proteins)/GSK-3beta/Snail (show SNAI1 Proteins) signals.

  2. CCL21/CCR7 (show CCR7 Proteins) induce VEGF-D (show Figf Proteins) up-regulation and promote lymphangiogenesis via ERK (show EPHB2 Proteins)/Akt (show AKT1 Proteins) pathway in lung cancer.

  3. Our findings suggested that MUC1 (show MUC1 Proteins) plays an important role in CCL21-CCR7 (show CCR7 Proteins)-induced lymphatic metastasis and may serve as a therapeutic target in esophageal squamous cell carcinoma .

  4. TGF-beta1 (show TGFB1 Proteins) promoted CCL21 expression in lymphatic endothelial cells. CCL21 acted in a paracrine fashion to mediate chemotactic migration of EMT (show ITK Proteins) cells toward lymphatic endothelial cells.

  5. The chemotactic interaction between CCR7 (show CCR7 Proteins) and its ligand, CCL21, may be a critical event during progression in pancreatic cancer

  6. CCL21 gene SNP (rs951005) might confer genetic predisposition to polymyositis patients or such patients with interstitial lung disease in a Chinese Han population.

  7. over-expression of CCL21 could increased the expressions of antigen presentation-related genes in CK8 (show KRT8 Proteins)/18 TECs in MG patients

  8. Priming by CCL21 restricts lateral mobility of the adhesion receptor LFA-1 (show ITGAL Proteins) and restores adhesion to ICAM-1 (show ICAM1 Proteins) nanoaggregates on human mature dendritic cells.

  9. CCL21/CCR7 (show CCR7 Proteins) pathway activates signallings to up-regulate Slug (show SNAI2 Proteins) pathway, leading to the occurrence of epithelial-mesenchymal transition process in human chondrosarcoma

  10. These results reveal that CCR7 (show CCR7 Proteins) and VEGF-C (show VEGFC Proteins) display a significant crosstalk and suggest a novel role of the CCL21/CCR7 (show CCR7 Proteins) chemokine (show CCL1 Proteins) axis in the promotion of breast cancer-induced lymphangiogenesis.

Mouse (Murine) Chemokine (C-C Motif) Ligand 21 (CCL21) interaction partners

  1. the CCR7 (show CCR7 Proteins)/CCL21 signaling pathway leading to T lymphocyte migration on fibronectin (show FN1 Proteins) is a beta1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCgamma1 (show PLCG1 Proteins)

  2. Data suggest that lymphotoxin (show LTB Proteins)-dependent and -independent regulation of CC chemokine ligand 21-b and -c plays a role in balancing the central and peripheral immune responses between lymphoid and nonlymphoid tissues.

  3. CCL21 and, to a lesser extent, CCL19 (show CCL19 Proteins) play significant roles in the distinctive localization of marginal zone macrophages within the splenic marginal zone.

  4. CCL21 and 5'-Nase may be involved in the interaction between infiltrating cells and lymphatic vessels to induce the functional changes of lymphatic endothelial cells during insulitic and diabetic development

  5. CXCL9 (show CXCL9 Proteins) has a role in graft rejection in the absence of CCL19 (show CCL19 Proteins) and CCL21

  6. T-cell defects in the nasal-associated lymphoid tissue of lymphotoxin (show LTB Proteins)(-/-) mice can be attributed to the impaired expression of CCL21.

  7. alpha-GalCer-loaded dendritic cells expressing tumor-associated antigen along with SLC (show CCL21A Proteins) can stimulate multiple subsets of effector cells to induce a potent therapeutic effect against peritoneally disseminated tumor cells.

  8. following Leishmania donovani infection of mice, the migration of splenic DC is regulated by the CCR7 (show CCR7 Proteins) ligands CCL19 (show CCL19 Proteins)/CCL21

  9. Results suggest that CCR7 (show CCR7 Proteins)-positive fibrocytes infiltrate the kidney via CCL21-positive vessels, thereby contributing to the pathogenesis of renal fibrosis.

  10. The presence of CCL21 during the in vitro stimulation of CD4 (show CD4 Proteins)+ T cells with anti-CD3 (show CD3E Proteins) plus anti-CD28 (show CD28 Proteins) significantly enhanced in vitro AICD induction of the restimulated T cells, partially through enhancing expression of Fas ligand (show FASL Proteins).

CCL21 Protein Profile

Protein Summary

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).

Gene names and symbols associated with CCL21

  • chemokine (C-C motif) ligand 21 (CCL21)
  • CCL21 (SLC)
  • C-C motif chemokine 21 (ccl21)
  • small inducible cytokine A24 (LOC100354652)
  • chemokine (C-C motif) ligand 21C (leucine) (Ccl21c)
  • 6Ckine protein
  • ccl21 protein
  • Ccl21b protein
  • CKb9 protein
  • ECL protein
  • exodus-2 protein
  • Scya21 protein
  • Scya21b protein
  • Scya21c protein
  • SLC protein
  • TCA4 protein

Protein level used designations for CCL21

C-C motif chemokine 21 , CC chemokine ligand 21 , putative CCL21 chemokine , small inducible cytokine A21 , CCL21 , small inducible cytokine A24 , Efficient Chemoattractant for Lymphocytes , beta chemokine exodus-2 , secondary lymphoid tissue chemokine , small inducible cytokine subfamily A (Cys-Cys), member 21 , chemokine CCL21/6CKINE , small-inducible cytokine A21 , C-C motif chemokine 21b , C-C motif chemokine 21c , Ccl21-leu , Small-inducible cytokine A21b , beta-chemokine exodus-2 , small inducible cytokine A21c , small-inducible cytokine A21c , thymus-derived chemotactic agent 4

448796 Canis lupus familiaris
448797 Sus scrofa
511112 Bos taurus
746205 Pan troglodytes
100144337 Oryctolagus cuniculus
100196238 Salmo salar
100354652 Oryctolagus cuniculus
6366 Homo sapiens
574183 Macaca mulatta
65956 Mus musculus
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