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CCR2 encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Additionally we are shipping CCR2 Kits (10) and CCR2 Proteins (5) and many more products for this protein.
Showing 10 out of 215 products:
Human Monoclonal CCR2 Primary Antibody for Func, IP - ABIN2656991
Barlic, Murphy: Chemokine regulation of atherosclerosis. in Journal of leukocyte biology 2007
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Human Monoclonal CCR2 Primary Antibody for FACS, ELISA - ABIN2662499
Gu, Okada, Clinton, Gerard, Sukhova, Libby, Rollins: Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. in Molecular cell 1998
Show all 6 references for ABIN2662499
Human Polyclonal CCR2 Primary Antibody for IHC (fp), ELISA - ABIN2165625
Bhangoo, Ren, Miller, Henry, Lineswala, Hamdouchi, Li, Monahan, Chan, Ripsch, White: Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. in Molecular pain 2008
Show all 3 references for ABIN2165625
Human Polyclonal CCR2 Primary Antibody for WB - ABIN2787666
Hendrickson, Jacobson, Nelson, Phair, Lautenberger, Johnson, Kingsley, Margolick, Detels, Goedert, OBrien: Host genetic influences on highly active antiretroviral therapy efficacy and AIDS-free survival. in Journal of acquired immune deficiency syndromes (1999) 2008
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CCR2 gene polymorphism (64I allele carriage) is a predisposing factor for allergy.
data suggest that the CCR2-64I polymorphism is associated with the protective effect to development of cervical lesions as well as in the protection to HPV 16 infection.
Ovarian cancer cells express both Hp and its receptor CCR2 but only after exposure to ascitic fluid, inducing moderated cell migration; results suggest that Hp-induced changes in the cell morphology, actin cytoskeleton structure, and migration ability of tumor cells, is possibly "preparing" these cells for the potential induction of the metastatic phenotype.
The frequencies of the rare alleles of CCR2, ITGB3 (show ITGB3 Antibodies), and 3'UTR (show UTS2R Antibodies) of c-fms (show CSF1R Antibodies) in the Old Believers are lower than in the sample of Novosibirsk Russians, and the rare allele of DBH (show DBH Antibodies) is more frequent
Among HIV-seropositive samples 3.4% were homozygous CCR2-64I mutants, 17.8%) were heterozygous,78.8% were CCR2 wild type.
results suggest that senescent dermal fibroblasts recruit stem cells by secreting various factors and that the CCL2/CCR2 axis is one of the mechanisms underlying this phenomenon
Association of hydrogen sulfide (show SQRDL Antibodies) with alterations of monocyte chemokine (show CCL1 Antibodies) receptors, CCR2 and CX3CR1 (show CX3CR1 Antibodies) in patients with coronary artery disease
A polymorphism in MCP-1 may be correlated with the development of non-small cell clung cancer (NSCLC) in the Han nationality of Northern China. However, the polymorphism in CCR-2 is not involved in NSCLC.
Results show that nerve-released CCL2 supports prostate cancer migration and perineural invasion though CCR2-mediated signaling.
Study shows the increase of CCR2 gene expression in monocytes of severe obstructive sleep apnea patients and that monocytic CCR2 gene expression can be induced under intermittent hypoxia which contributes to the chemotaxis and adhesion of monocytes.
Disruption of CCR2 enhanced tau pathology and reduced cavity volume in mild traumatic brain injury.
In the absence of the rd8 allele, deficiency of CCR2 and CX3CL1 (show CX3CL1 Antibodies) in mice leads to a mild form of retinal degeneration which is associated with the recruitment of macrophages, particularly to the subretinal space. This model enables to assess consequences of perturbed chemokine (show CCL1 Antibodies) signaling, but it does not recapitulate cardinal (show CARD8 Antibodies) age-related macular degeneration features.
The results indicate that AMPK (show PRKAA1 Antibodies) is a negative regulator of Ccr2 expression in RAW264.7 macrophages, and that the mechanism of action of AMPK (show PRKAA1 Antibodies) inhibition of Ccr2 is mediated, in part, through the NF-kappaB (show NFKB1 Antibodies) pathway.
upon binding to a composite NFAT (show NFATC1 Antibodies)/BCL6 (show BCL6 Antibodies) regulatory element within the Ccl2 (show CCL2 Antibodies) promoter, NFATc1 (show NFATC1 Antibodies)/beta proteins release the BCL6 (show BCL6 Antibodies)-dependent repression of Ccl2 (show CCL2 Antibodies) gene in macrophages.
results demonstrate the central role CCR2 plays in mediating leukocyte mobilization from the BM, and suggest a role for CCR2 inhibition in managing monocytes/macrophages-mediated chronic inflammatory conditions
cellular fibrin uptake was diminished by elimination of CCR2-expressing cells.
CCL2/CCR2 signaling pathway may provide a novel therapeutic target to prevent renal disease progression in patients with renovascular hypertension.
In Ccr2(-/-) mice, in which monocyte-derived macrophage infiltration is impaired, silica administration induced diffuse PF with loose nodule formation and greater activation of tissue cells.
IL-23 (show IL23A Antibodies)/IL-1 (show IL1A Antibodies)/IFNgamma/TNFalpha (show TNF Antibodies)/T-bet/Eomesodermin (show EOMES Antibodies)-driven circuit drives GM-CSF (show CSF2 Antibodies)/IFNgamma-producing Th17 cell development.
a Th1 response in the modulation of Th2 allergic inflammation, our findings also attribute an important role to the innate response mediated by TLR9, associated with the recruitment of CCR2-dependent monocytes.
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
C-C chemokine receptor type 2
, MCP-1 receptor
, monocyte chemoattractant protein 1 receptor
, monocyte chemotactic protein 1 receptor
, C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR)
, C-C CKR-2
, JE/FIC receptor
, MIP-1 alphaR
, chemoattractant protein-1 receptor
, chemokine (C-C) receptor 2
, chemokine receptor CCR2
, chemokine receptor