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CBX5 encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. Additionally we are shipping CBX5 Proteins (8) and CBX5 Kits (1) and many more products for this protein.
Showing 10 out of 248 products:
Human Monoclonal CBX5 Primary Antibody for IF, WB - ABIN393505
Nozawa, Nagao, Masuda, Iwasaki, Hirota, Nozaki, Kimura, Obuse: Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. in Nature cell biology 2010
Show all 5 references for ABIN393505
Human Polyclonal CBX5 Primary Antibody for ChIP, IHC (p) - ABIN258235
Bawa-Khalfe, Lu, Zuo, Huang, Dere, Lin, Yeh: Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition. in Proceedings of the National Academy of Sciences of the United States of America 2012
Show all 3 references for ABIN258235
Human Polyclonal CBX5 Primary Antibody for WB - ABIN657701
Emelyanov, Konev, Vershilova, Fyodorov: Protein complex of Drosophila ATRX/XNP and HP1a is required for the formation of pericentric beta-heterochromatin in vivo. in The Journal of biological chemistry 2010
Show all 3 references for ABIN657701
Human Polyclonal CBX5 Primary Antibody for IHC (p), IHC - ABIN250893
Rohr, Lecestre, Chasserot-Golaz, Marban, Avram, Aunis, Leid, Schaeffer: Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells. in Journal of virology 2003
Human Polyclonal CBX5 Primary Antibody for ELISA, WB - ABIN1533736
Minc, Allory, Worman, Courvalin, Buendia: Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells. in Chromosoma 1999
Cow (Bovine) Polyclonal CBX5 Primary Antibody for IHC, WB - ABIN2779672
Fujita, Watanabe, Ichimura, Tsuruzoe, Shinkai, Tachibana, Chiba, Nakao: Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression. in The Journal of biological chemistry 2003
HP1-alpha oligomerization is critical to the maintenance of heterochromatin and the tunable dynamics of this HP1 isoform.
demonstrate an actin-driven differential modulation of core histone H2B and heterochromatin HP1alpha protein dynamics with chromatin
the molecular behavior of HP1alpha throughout the cell cycle
There is a functional link between prelamin A, HP1alpha, chromatin remodeling, DNA repair, and early senescence in Zmpste24 (show Zmpste24 Antibodies)-deficient mice, suggesting a potential therapeutic strategy for laminopathy-based premature aging via the intervention of HP1alpha.
the TIF1beta (show TRIM28 Antibodies)-HP1 system functions as a critical repressive machinery that targets genes not normally activated in the hematopoietic compartment, thereby maintaining the transcriptional signature specific to HSCs.
HP1 mobility in apoptotic cells appeared to be unique.
Elimination of HP1alpha by siRNA interfered with centromere relocation from heterochromatin surrounding NPBs to pro-chromocenters at the two-cell stage but did not affect preimplantation develoment to the blastocyst stage.
Depletion of Senp7 (show SENP7 Antibodies) delocalizes HP1 alpha from pericentric heterochromatin without affecting H3K9me3 levels.
The interplay between MU2 (show AP2M1 Antibodies) and HP1a is dynamic and may be different in euchromatin and heterochromatin during DNA break recognition and repair.
KAP1 (show TRIM28 Antibodies) and HP1 tether activation-induced cytidine deaminase (show AICDA Antibodies) (AID) to H3K9me3 residues at the donor switch region, thus linking AID to epigenetic modifications during class switch recombination.
we showed the essential role of HP1 (show DEFA1 Antibodies) in regulating HR through BRCA1/BARD1 (show BARD1 Antibodies)-mediated accumulation of FANCJ (show BRIP1 Antibodies) and CtIP (show RBBP8 Antibodies) at DSB sites. This mechanism may affect tumorigenesis and chemosensitivity and is thus of high clinical significance.
We demonstrate that an hnRNPA1 (show HNRNPA1 Antibodies) and CBX5 bi-directional core promoter fragment does not comprise intrinsic capacity for specific CBX5 down-regulation in metastatic cells
HP1alpha plays an important role in the differentiation and angiogenic function of Endothelial Progenitor Cells.
Jra recruits the HP1a (show TFF1 Antibodies)/KDM4A (show KDM4A Antibodies) complex to its gene body region upon osmotic stress to reduce H3K36 methylation levels and disrupt H3K36 methylation-dependent histone deacetylation
SET interacts with the Kruppel-associated box (KRAB)-associated co-repressor KAP1 (show CDKN3 Antibodies), and its overexpression results in the sustained retention of KAP1 (show CDKN3 Antibodies) and Heterochromatin protein 1 (HP1 (show DEFA1 Antibodies)) on chromatin
HP1 (show DEFA1 Antibodies) regulates this gene's alternative splicing in a methylation-dependent manner by recruiting splicing factors to its methylated form.
PIP5K1A (show PIP5K1A Antibodies) modulates ribosomal RNA gene silencing through its interaction with histone H3 (show HIST3H3 Antibodies) lysine 9 trimethylation and heterochromatin protein HP1-alpha.
Paternal heterochromatin formation in human embryos is H3K9/HP1 (show DEFA1 Antibodies) directed and primed by sperm-derived histone modifications.
a considerable number of alternative splicing events could have a chromatin-dependent regulation involving the association of HP1alpha and CTCF (show CTCF Antibodies) near regulated exons.
Identify a nuclear localization signal within the 462-494 amino acid region of TRIM28 (show TRIM28 Antibodies) that overlaps with its HP1 (show DEFA1 Antibodies) binding site. GST (show SLCO6A1 Antibodies)-pulldown experiments revealed the interaction of the arginine-rich TRIM28 (show TRIM28 Antibodies) NLS (show ALDH1A2 Antibodies) with various importin alpha (show KPNA4 Antibodies) subtypes.
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
chromobox protein homolog 5
, chromobox homolog 5 (HP1 alpha homolog, Drosophila)
, chromobox-like protein 5 (HP1 alpha homolog, Drosophila)
, HP1 alpha
, chromobox homolog 5
, heterochromatin protein 1 alpha
, heterochromatin protein 1 homolog alpha
, HP1 alpha homolog
, HP1Hs alpha
, antigen p25
, heterochromatin protein 1-alpha
, chromobox-like protein 5
, chromobox homolog 5 tv3