anti-Chromobox Homolog 5 (CBX5) Antibodies

CBX5 encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. Additionally we are shipping CBX5 Proteins (8) and CBX5 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CBX5 23468 P45973
CBX5 300266  
CBX5 12419 Q61686
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Top anti-CBX5 Antibodies at

Showing 10 out of 272 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-CBX5 Antibody Titration: </b>1.25ug/ml<br><b>Positive Control: </b>Human brain 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB CBX5 Antibody (Center) (ABIN657701) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the CBX5 antibody detected the CBX5 protein (arrow). 400 μL Log in to see 10 to 11 Days
Cow Rabbit Un-conjugated IC, IF, IP, IHC, WB Immunofluorescent analysis of HP1 alpha staining in NIH3T3 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of HP1 alpha staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
Human Goat Un-conjugated IHC, ELISA, WB ABIN185491 (0.03µg/ml) staining of Hela lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN185491 (2.5µg/ml) staining of paraffin embedded Human Uterus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 100 μg Log in to see 6 to 7 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HeLa/A549/K562 cells, using CBX5 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to CBX5 on HeLa cell (antibody concentration 10 µg/mL).  CBX5 monoclonal antibody (M01), clone 1E11-3A10 Western Blot analysis of CBX5 expression in HeLa NE. 0.1 mg Log in to see 8 to 11 Days
Human Goat Un-conjugated IHC (p), IHC, ELISA, WB ABIN250893 (0.03ug/ml) staining of Hela lysate (35ug protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Western Blot: HP1 alpha Antibody [ABIN250893] - Analysis of HP1 alpha in Hela lysate using this antibody at 0.03ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated ChIP, IHC (p), IP, IHC, PLA, WB Immunohistochemistry-Paraffin: HP1 alpha Antibody [ABIN2582353] - Human prostate carcinoma. Antibody used at a dilution of 1:5,000 (0.2ug/ml). 100 μL Log in to see 7 to 9 Days
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Log in to see 16 Days
Cow Goat Un-conjugated IHC (p), ELISA, WB Human Uterus (formalin-fixed, paraffin-embedded) stained with CBX5 antibody ABIN337121 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days

CBX5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CBX5 Antibodies

  1. Human Polyclonal CBX5 Primary Antibody for ChIP, IHC (p) - ABIN258235 : Bawa-Khalfe, Lu, Zuo, Huang, Dere, Lin, Yeh: Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal CBX5 Primary Antibody for IF, WB - ABIN2452033 : Wang, Koyama, Nishida, Haraguchi, Reith, Tsukamoto: The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells. in Molecular and cellular biology 2006 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal CBX5 Primary Antibody for ChIP, ICC - ABIN2668529 : Shestakova, Mansuroglu, Mokrani, Ghinea, Bonnefoy: Transcription factor YY1 associates with pericentromeric gamma-satellite DNA in cycling but not in quiescent (G0) cells. in Nucleic acids research 2004 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal CBX5 Primary Antibody for IHC (p), IHC - ABIN250893 : Rohr, Lecestre, Chasserot-Golaz, Marban, Avram, Aunis, Leid, Schaeffer: Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells. in Journal of virology 2003 (PubMed)

More Antibodies against CBX5 Interaction Partners

Human Chromobox Homolog 5 (CBX5) interaction partners

  1. Identify a nucleosome interaction module within KDM2A (show KDM2A Antibodies) consisting of a CXXC type zinc finger, a PHD (show PDC Antibodies) domain and a newly identified Heterochromatin Protein 1 (HP1 (show DEFA1 Antibodies)) interaction motif that mediates direct binding between KDM2A (show KDM2A Antibodies) and HP1 (show DEFA1 Antibodies). This nucleosome interaction module enables KDM2A (show KDM2A Antibodies) to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals.

  2. These data suggests that up-regulated HP1A (show TFF1 Antibodies) and H3K9me3 in glioma cells are functionally associated with glioma pathogenesis and progression.

  3. Loss of HP1alpha and gamma isoforms inhibits the upregulation of Suv39h1 (show SUV39H1 Antibodies) and H3K9me3 that is observed under stress conditions.

  4. we showed the essential role of HP1 (show DEFA1 Antibodies) in regulating HR through BRCA1/BARD1 (show BARD1 Antibodies)-mediated accumulation of FANCJ (show BRIP1 Antibodies) and CtIP (show RBBP8 Antibodies) at DSB sites. This mechanism may affect tumorigenesis and chemosensitivity and is thus of high clinical significance.

  5. We demonstrate that an hnRNPA1 (show HNRNPA1 Antibodies) and CBX5 bi-directional core promoter fragment does not comprise intrinsic capacity for specific CBX5 down-regulation in metastatic cells

  6. HP1alpha plays an important role in the differentiation and angiogenic function of Endothelial Progenitor Cells.

  7. Jra recruits the HP1a (show TFF1 Antibodies)/KDM4A (show KDM4A Antibodies) complex to its gene body region upon osmotic stress to reduce H3K36 methylation levels and disrupt H3K36 methylation-dependent histone deacetylation

  8. SET interacts with the Kruppel-associated box (KRAB)-associated co-repressor KAP1 (show CDKN3 Antibodies), and its overexpression results in the sustained retention of KAP1 (show CDKN3 Antibodies) and Heterochromatin protein 1 (HP1 (show DEFA1 Antibodies)) on chromatin

  9. HP1 (show DEFA1 Antibodies) regulates this gene's alternative splicing in a methylation-dependent manner by recruiting splicing factors to its methylated form.

  10. PIP5K1A (show PIP5K1A Antibodies) modulates ribosomal RNA gene silencing through its interaction with histone H3 (show HIST3H3 Antibodies) lysine 9 trimethylation and heterochromatin protein HP1-alpha.

Mouse (Murine) Chromobox Homolog 5 (CBX5) interaction partners

  1. HP1-alpha oligomerization is critical to the maintenance of heterochromatin and the tunable dynamics of this HP1 isoform.

  2. demonstrate an actin-driven differential modulation of core histone H2B and heterochromatin HP1alpha protein dynamics with chromatin

  3. the molecular behavior of HP1alpha throughout the cell cycle

  4. There is a functional link between prelamin A, HP1alpha, chromatin remodeling, DNA repair, and early senescence in Zmpste24 (show Zmpste24 Antibodies)-deficient mice, suggesting a potential therapeutic strategy for laminopathy-based premature aging via the intervention of HP1alpha.

  5. the TIF1beta (show TRIM28 Antibodies)-HP1 system functions as a critical repressive machinery that targets genes not normally activated in the hematopoietic compartment, thereby maintaining the transcriptional signature specific to HSCs.

  6. HP1 mobility in apoptotic cells appeared to be unique.

  7. Elimination of HP1alpha by siRNA interfered with centromere relocation from heterochromatin surrounding NPBs to pro-chromocenters at the two-cell stage but did not affect preimplantation develoment to the blastocyst stage.

  8. Depletion of Senp7 (show SENP7 Antibodies) delocalizes HP1 alpha from pericentric heterochromatin without affecting H3K9me3 levels.

  9. The interplay between MU2 (show AP2M1 Antibodies) and HP1a is dynamic and may be different in euchromatin and heterochromatin during DNA break recognition and repair.

  10. KAP1 (show TRIM28 Antibodies) and HP1 tether activation-induced cytidine deaminase (show AICDA Antibodies) (AID) to H3K9me3 residues at the donor switch region, thus linking AID to epigenetic modifications during class switch recombination.

CBX5 Antigen Profile

Protein Summary

Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.

Gene names and symbols associated with CBX5

  • chromobox homolog 5 (CBX5) antibody
  • chromobox homolog 5 (HP1 alpha homolog, Drosophila) (cbx5) antibody
  • chromobox homolog 5 (HP1 alpha homolog, Drosophila) (CBX5) antibody
  • chromobox homolog 5 (Cbx5) antibody
  • chromobox homolog 5 (cbx5) antibody
  • defensin, alpha 1B (DEFA1B) antibody
  • chromobox 5 (Cbx5) antibody
  • 2610029O15Rik antibody
  • C75991 antibody
  • cbx5 antibody
  • HNP-1 antibody
  • HP-1 antibody
  • HP1 antibody
  • Hp1a antibody
  • Hp1alpha antibody
  • id:ibd2026 antibody
  • MGC64354 antibody
  • wu:fc63e02 antibody
  • wu:fe47g12 antibody
  • wu:fi03h05 antibody
  • zgc:158601 antibody

Protein level used designations for CBX5

HP1 alpha homolog , HP1-ALPHA , HP1Hs alpha , antigen p25 , chromobox homolog 5 (HP1 alpha homolog, Drosophila) , chromobox protein homolog 5 , heterochromatin protein 1 homolog alpha , heterochromatin protein 1-alpha , fc63e02 , chromobox-like protein 5 , chromobox-like protein 5 (HP1 alpha homolog, Drosophila) , neutrophil defensin 1 , HP1 alpha , chromobox homolog 5 , heterochromatin protein 1 alpha , mHP1(alpha) , chromobox homolog 5 tv3

23468 Homo sapiens
563396 Danio rerio
538885 Bos taurus
477593 Canis lupus familiaris
467011 Pan troglodytes
300266 Rattus norvegicus
100307036 Ovis aries
380557 Xenopus laevis
394502 Xenopus (Silurana) tropicalis
728358 Homo sapiens
12419 Mus musculus
100519426 Sus scrofa
Selected quality suppliers for anti-CBX5 (CBX5) Antibodies
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