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anti-Class II Transactivator (CIITA) Antibodies

Essential for transcriptional activity of the HLA class II promoter\; activation is via the proximal promoter.

list all antibodies Gene Name GeneID UniProt
CIITA 12265 P79621
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Top anti-Class II Transactivator Antibodies at

Showing 2 out of 3 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-C2TA Antibody Titration: 0.125ug/mlELISA Titer: 1:62500Positive Control: NIH/3T3 cell lysate 100 μL Log in to see 2 to 3 Days
Mouse Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days

CIITA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)

Dog (Canine)

Rat (Rattus)

Top referenced anti-Class II Transactivator Antibodies

  1. Dog (Canine) Polyclonal CIITA Primary Antibody for WB - ABIN2779823 : Pennini, Pai, Schultz, Boom, Harding: Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-gamma-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling. in Journal of immunology (Baltimore, Md. : 1950) 2006 (PubMed)

More Antibodies against Class II Transactivator Interaction Partners

Mouse (Murine) Class II Transactivator (CIITA) interaction partners

  1. this study shows that genetic polymorphisms in the type I promoter of C2ta regulate MHC-II expression and T-cell responses but do not necessarily have a strong impact on autoimmune diseases

  2. CIITA interacted with and recruited PRMT5 to the MHC II promoter and mediated the synergy between PRMT5 and ASH2/WDR5 to activate MHC II transcription

  3. NLRC5 (show NLRC5 Antibodies) and CIITA thus emerge as paradigms for a novel class of transcriptional regulators dedicated for transactivating extremely few, phylogenetically related genes.

  4. Data suggest that class II transactivator CIITA expression is likely mediated in hematopoietic cells by common elements with promoter accessibility having a part in promoter choice.

  5. Transfection of CIITA in poorly immunogenic PDA cells resulted in increased expression levels of the MHC class II molecule. CIITA-tumor cells were rejected in 80% to 100% of injected mice.

  6. IFN-gamma exerts a critical anti-inflammatory function in the intestine which protects against colitis by inducing MHCII expression on intestinal epithelial cells.

  7. tumor cell lines with a defective expression of CIITA transcripts lack MHC class II expression

  8. study provides compelling genetic evidence that CIITA, the molecular switch of antigen presentation, plays a novel, unexpected function in skeletal homeostasis, independent of MHC Class II expression and T cells

  9. Data indicate that during Mycobacterium bovis BCG (show SLC11A1 Antibodies) infection, iNOS (show NOS2 Antibodies)/NO responsive KLF4 (show KLF4 Antibodies) induces EZH2 (show EZH2 Antibodies) and miR (show MLXIP Antibodies)-150 functions to regulate CIITA expression.

  10. CIITA isoform I is dispensable for proper T-cell development.

Class II Transactivator (CIITA) Antigen Profile

Protein Summary

Essential for transcriptional activity of the HLA class II promoter\; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (By similarity).

Gene names and symbols associated with CIITA

  • class II transactivator (Ciita) antibody
  • C2ta antibody
  • EG669998 antibody
  • Gm9475 antibody

Protein level used designations for CIITA

MHC class II transactivator

12265 Mus musculus
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