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Essential for transcriptional activity of the HLA class II promoter\; activation is via the proximal promoter.
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Dog (Canine) Polyclonal CIITA Primary Antibody for WB - ABIN2779823
Pennini, Pai, Schultz, Boom, Harding: Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-gamma-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling. in Journal of immunology (Baltimore, Md. : 1950) 2006
this study shows that genetic polymorphisms in the type I promoter of C2ta regulate MHC-II expression and T-cell responses but do not necessarily have a strong impact on autoimmune diseases
CIITA interacted with and recruited PRMT5 to the MHC II promoter and mediated the synergy between PRMT5 and ASH2/WDR5 to activate MHC II transcription
NLRC5 (show NLRC5 Antibodies) and CIITA thus emerge as paradigms for a novel class of transcriptional regulators dedicated for transactivating extremely few, phylogenetically related genes.
Data suggest that class II transactivator CIITA expression is likely mediated in hematopoietic cells by common elements with promoter accessibility having a part in promoter choice.
Transfection of CIITA in poorly immunogenic PDA cells resulted in increased expression levels of the MHC class II molecule. CIITA-tumor cells were rejected in 80% to 100% of injected mice.
IFN-gamma exerts a critical anti-inflammatory function in the intestine which protects against colitis by inducing MHCII expression on intestinal epithelial cells.
tumor cell lines with a defective expression of CIITA transcripts lack MHC class II expression
study provides compelling genetic evidence that CIITA, the molecular switch of antigen presentation, plays a novel, unexpected function in skeletal homeostasis, independent of MHC Class II expression and T cells
Data indicate that during Mycobacterium bovis BCG (show SLC11A1 Antibodies) infection, iNOS (show NOS2 Antibodies)/NO responsive KLF4 (show KLF4 Antibodies) induces EZH2 (show EZH2 Antibodies) and miR (show MLXIP Antibodies)-150 functions to regulate CIITA expression.
CIITA isoform I is dispensable for proper T-cell development.
Essential for transcriptional activity of the HLA class II promoter\; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (By similarity).
MHC class II transactivator