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Essential for transcriptional activity of the HLA class II promoter\; activation is via the proximal promoter.
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study found that CIITA exerts a highly restricted control over only the MHCII, H2-DO and H2-DM genes, in DC1 and DC2 cDC (show CDK1 Antibodies) subsets, but not over other proposed targets
Decreasing CIITA expression in allogeneic MSCs abolished MHC II induction during myogenic differentiation and prevented immunorejection of these cells from the infarcted myocardium, which enhanced beneficial functional effects of MSC (show MSC Antibodies) implantation on myocardial repair.
M. tuberculosis EsxL inhibits antigen presentation by enhancing H3K9me2/3 at the CIITA promoter, thereby repressing its expression through NO and p38 MAPK (show MAPK14 Antibodies) activation
this study shows that genetic polymorphisms in the type I promoter of C2ta regulate MHC-II expression and T-cell responses but do not necessarily have a strong impact on autoimmune diseases
CIITA interacted with and recruited PRMT5 to the MHC II promoter and mediated the synergy between PRMT5 and ASH2/WDR5 to activate MHC II transcription
NLRC5 (show NLRC5 Antibodies) and CIITA thus emerge as paradigms for a novel class of transcriptional regulators dedicated for transactivating extremely few, phylogenetically related genes.
Data suggest that class II transactivator CIITA expression is likely mediated in hematopoietic cells by common elements with promoter accessibility having a part in promoter choice.
Transfection of CIITA in poorly immunogenic PDA cells resulted in increased expression levels of the MHC class II molecule. CIITA-tumor cells were rejected in 80% to 100% of injected mice.
IFN-gamma exerts a critical anti-inflammatory function in the intestine which protects against colitis by inducing MHCII expression on intestinal epithelial cells.
tumor cell lines with a defective expression of CIITA transcripts lack MHC class II expression
Essential for transcriptional activity of the HLA class II promoter\; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter (By similarity).
MHC class II transactivator