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Claudin 1 Proteins (CLDN1)

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. Additionally we are shipping Claudin 1 Antibodies (157) and Claudin 1 Kits (55) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLDN1 9076 O95832
CLDN1 12737 O88551
Rat CLDN1 CLDN1 65129 P56745
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Top Claudin 1 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

CLDN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Top referenced Claudin 1 Proteins

  1. Human Claudin 1 Protein expressed in Wheat germ - ABIN1349581 : Broussard, Kim, Wiley, Marquez, Annis, Pritchard, Disis: Identification of putative immunologic targets for colon cancer prevention based on conserved gene upregulation from preinvasive to malignant lesions. in Cancer prevention research (Philadelphia, Pa.) 2013 (PubMed)
    Show all 5 references for ABIN1349581

More Proteins for Claudin 1 (CLDN1) Interaction Partners

Xenopus laevis Claudin 1 (CLDN1) interaction partners

Pig (Porcine) Claudin 1 (CLDN1) interaction partners

  1. Cyclosporine A/sirolimus alter claudin-1 expression in renal proximal tubular cells via ERK1/2 signaling pathway to alter barrier function.

Human Claudin 1 (CLDN1) interaction partners

  1. Claudin-1 (show CLDN7 Proteins) expression was correlated with lymphatic microvessel generation in hypopharyngeal squamous cell carcinoma and with patient survival.

  2. High CLAUDIN-1 (show CLDN7 Proteins) expression is associated with metastasis in follicular thyroid carcinoma.

  3. The highest expression of claudin-1 (show CLDN7 Proteins) was observed in well-differentiated oral squamous cell carcinomas, whereas poorly differentiated tumors exhibited mostly no expression of claudin-1 (show CLDN7 Proteins).

  4. Report genetic polymorphism of TJ component claudin-1 (show CLDN7 Proteins) and their haplotypes are associated with leukoaraiosis.

  5. Using a human liver-chimeric mouse model, we show that a monoclonal antibody specific for the TJ protein claudin-1 (show CLDN7 Proteins) (ref (show THOC4 Proteins). 7) eliminates chronic HCV infection without detectable toxicity

  6. delocalization of claudin-1 induced by PKC phosphorylation contributes to metastatic capacity of osteosarcoma cells

  7. The expressions of MARVELD2 (show MARVELD2 Proteins), CLDN1 and CLDN3 (show CLDN3 Proteins) mRNA were significantly lower in cholesteatoma tissue and may be involved in epithelium permeability.

  8. There was no difference in the frequency of fractures or renal lithiasis between the rs219780 genotype groups in PHPT patients. Nor was there any relationship between the T or C alleles and BMD (show BEST1 Proteins) or biochemical parameters.

  9. CLD1-mediated hepatoma cell invasiveness occurs via heat shock factor 1 (HSF1) activation.

  10. Findings suggest that CLDN1 is oncogenic in gastric cancer and its malignant potential may be attributed in part to regulation of anoikis, by mediating membrane beta-catenin (show CTNNB1 Proteins)-regulated cell-cell adhesion and cell survival.

Mouse (Murine) Claudin 1 (CLDN1) interaction partners

  1. Data show that the spatiotemporal expression of claudin-1 is dysregulated in homeobox (show PRRX1 Proteins) (Msx) genes Msx1d/d/Msx2d/d uteri.

  2. Cldn-1 is a positive regulator of osteoblast proliferation and differentiation.

  3. We further demonstrate that KRT76 interacts with CLDN1 and propose that this interaction is necessary to correctly position CLDN1 in tight junctions.

  4. MIR29 targets and reduces expression of CLDN1 and NKRF (show NKRF Proteins) to increase intestinal permeability in inflammatory bowel disease.

  5. Occludin (show OCLN Proteins) and Claudin-1 expressions in the large intestine are under the circadian control, which is associated with temporal regulation of colonic permeability and also susceptibility to colitis.

  6. regulates intestinal epithelial homeostasis via regulation of Notch (show NOTCH1 Proteins)-signalling

  7. Downregulation of Sirt1 (show SIRT1 Proteins) and upregulation of the tight junction protein Claudin-1 by SIRT1 (show SIRT1 Proteins)-mediated epigenetic regulation in podocytes contributed to albuminuria.

  8. Cldn1(-/-) mice exhibited the abnormal stratum granulosum formation and stratum corneum barrier defects.

  9. miR (show MLXIP Proteins)-155 may prevent tumorigenesis in human ovarian cancer through downregulation of CLDN1

  10. Claudin-1 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, dark cell area.

Cow (Bovine) Claudin 1 (CLDN1) interaction partners

Claudin 1 (CLDN1) Protein Profile

Protein Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Gene names and symbols associated with Claudin 1 Proteins (CLDN1)

  • claudin-1-like (LOC100059811)
  • claudin 1 (cldn1)
  • claudin 1-like (LOC396566)
  • claudin 1 (CLDN1)
  • claudin 1 (Cldn1)
  • AI596271 protein
  • claudin-1 protein
  • CLD1 protein
  • CLDN1 protein
  • cldn19 protein
  • ILVASC protein
  • SEMP1 protein

Protein level used designations for Claudin 1 Proteins (CLDN1)

claudin-1 , claudin 19 , claudin-1-like , claudin 1 , senescence-associated epithelial membrane protein 1 , tight junction protein

100059811 Equus caballus
81590 Danio rerio
379132 Xenopus laevis
396566 Sus scrofa
460934 Pan troglodytes
548421 Xenopus (Silurana) tropicalis
9076 Homo sapiens
608207 Canis lupus familiaris
12737 Mus musculus
65129 Rattus norvegicus
100625166 Sus scrofa
414922 Bos taurus
100037713 Oryctolagus cuniculus
100732605 Cavia porcellus
424910 Gallus gallus
780473 Ovis aries
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