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anti-Collagen, Type VIII, alpha 2 (COL8a2) Antibodies

COL8a2 encodes the alpha 2 chain of type VIII collagen. Additionally we are shipping COL8a2 Proteins (8) and COL8a2 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
COL8a2 1296 P25067
COL8a2 329941 P25318
COL8a2 313592  
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Top anti-COL8a2 Antibodies at

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, IHC (p), WB COL8A2 Antibody (C-term) (ABIN655804) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
Human Rabbit Un-conjugated IF, IHC, WB 400 μL Log in to see 6 Days
Human Rabbit Biotin IF, IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 11 to 13 Days
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 11 to 13 Days
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB Western Blot: COL8A2 Antibody [NBP2-30020] - Western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the COL8A2 antibody detected the COL8A2 protein (arrow). Immunocytochemistry/Immunofluorescence: COL8A2 Antibody [NBP2-30020] - Confocal immunofluorescent analysis of COL8A2 Antibody (C-term)(NBP2-30020) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). 0.4 mL Log in to see 8 to 11 Days

COL8a2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
, , , , ,
Mouse (Murine) ,

Rat (Rattus)

Top referenced anti-COL8a2 Antibodies

  1. Human Polyclonal COL8a2 Primary Antibody for WB - ABIN611143 : De Zeeuw, Hoogenraad, Goedknegt, Hertzberg, Neubauer, Grosveld, Galjart: CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies. in Neuron 1998 (PubMed)
    Show all 2 references for ABIN611143

  2. Human Polyclonal COL8a2 Primary Antibody for IF, IHC (p) - ABIN655804 : Okumura, Minamiyama, Ho, Kay, Kawasaki, Tourtas, Schlötzer-Schrehardt, Kruse, Young, Quantock, Kinoshita, Koizumi: Involvement of ZEB1 and Snail1 in excessive production of extracellular matrix in Fuchs endothelial corneal dystrophy. in Laboratory investigation; a journal of technical methods and pathology 2015 (PubMed)

More Antibodies against COL8a2 Interaction Partners

Human Collagen, Type VIII, alpha 2 (COL8a2) interaction partners

  1. Peripheral, anterior microcystic corneal edema represents a characteristic aspect of the phenotype associated with the p.(Leu450Trp) substitution in COL8A2, in at least 2 of 3 known affected families worldwide.

  2. No mutations were identified in COL8A2, in neither the late-onset cohort nor the early-onset family, suggesting genetic heterogeneity in this Late-onset Fuchs endothelial corneal dystrophy (FECD) family.

  3. mutations in the COL8A2 gene do not contribute to all cases of early-onset early-onset Fuchs' endothelial corneal dystrophy .

  4. Variation in the COL8A2, SLC4A11 (show SLC4A11 Antibodies), and ZEB1 (show ZEB1 Antibodies) genes is present in only a small fraction of African American cases and as such does not appear to significantly contribute to the genetic risk of Fuchs endothelial corneal dystrophy.

  5. Esophageal transcript profiling identified a distinct subset of genes, including COL8A2, in patients with Eosionophilic esophagitis and inherited connective tissue disorders.

  6. Association of central corneal thickness with TCF4 (show TCF4 Antibodies) was also significant (p = 6.1x10(-7)), but was abolished with adjustment for FECD grade (p = 0.92).

  7. Single nucleotide polymorphisms in COL8A2 gene is not associated with central corneal thickness in glaucoma.

  8. Report cellular model in which collagen VIII (show COX8A Antibodies) mutations, which clinically result in Fuchs' dystrophy, are associated with abnormal cellular accumulation of collagen VIII (show COX8A Antibodies).

  9. The purpose of this study is to evaluate COL8A1 (show COL8A1 Antibodies) and COL8A2 as candidate genes for thin central corneal thickness in human primary open angle glaucoma patients.

  10. These data constitute the first report of a heterozygous Q455V mutation of the COL8A2 gene in Korean patients with Fuchs' corneal dystrophy and Q455V may be the causative defect in the development and progression of Korean FECD patients.

Mouse (Murine) Collagen, Type VIII, alpha 2 (COL8a2) interaction partners

  1. Overexpression of the Col8a2 gene in mouse and human Fuchs endothelial corneal dystrophy endothelial cells suggested a role for altered autophagy in this disease.

  2. in contrast to diabetic wild-type mice EMT (show ITK Antibodies)-like changes were attenuated in diabetic Col8alpha1/alpha2-KO mice, indicating that collagen VIII (show COX8A Antibodies) may be 1 of the major inducers of epithelial-to-mesenchymal transition-like changes in kidneys of diabetic wild-type mice

  3. study confirms the Q455K substitution in the COL8A2 gene as being sufficient to cause FECD in the first mouse model of this disease and supports the role of the UPR and UPR-associated apoptosis in the pathogenesis of FECD caused by COL8A2 mutations

  4. Type VIII (show COX8A Antibodies) collagen significantly modulates the effect of TGF-beta1 (show TGFB1 Antibodies) on mesangial cells and may therefore play a role in the pathogenesis of diabetic nephropathy.

  5. Smooth muscle cells can modify the matrix microenvironment by producing type VIII (show COX8A Antibodies) collagen, using it to overlay type I collagen, and generating a substrate favorable for migration

  6. Lack of type VIII (show COX8A Antibodies) collagen confers renoprotection in diabetic nephropathy in a knockout mouse model.

  7. The mouse mutant Aca23 described here offers the first point mutation of the Col8a2 gene and suggests that a functional collagen VIII (show COX8A Antibodies) alpha2 gene is essential for the correct assembly of the Descemet's membrane and for corneal stability.

COL8a2 Antigen Profile

Protein Summary

This gene encodes the alpha 2 chain of type VIII collagen. The protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2.

Gene names and symbols associated with COL8a2

  • collagen, type VIII, alpha 2 (COL8A2) antibody
  • collagen, type VIII, alpha 2 (Col8a2) antibody
  • AI429819 antibody
  • FECD antibody
  • FECD1 antibody
  • PPCD antibody
  • PPCD2 antibody

Protein level used designations for COL8a2

collagen, type VIII, alpha 2 , collagen alpha-2(VIII) chain , collagen VIII, alpha-2 polypeptide , collagen type VIII alpha 2 , dJ665N4.1 (collagen type VIII alpha 2) , endothelial collagen , procollagen type VIII alpha 2 , procollagen, type VIII, alpha 2

428221 Gallus gallus
539415 Bos taurus
747856 Pan troglodytes
1296 Homo sapiens
329941 Mus musculus
313592 Rattus norvegicus
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