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The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Additionally we are shipping Cystatin D Antibodies (42) and Cystatin D Kits (5) and many more products for this protein.
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Results imply CST5 as an important mediator of tumor suppression by p53 (show TP53 Proteins) in colorectal cancer.
These results support an unanticipated role of cystatin D in the cell nucleus, controlling the transcription of specific genes involved in crucial cellular functions, which may mediate its protective action in colon cancer.
activation of the RhoA (show RHOA Proteins)-ROCK-p38MAPK (show MAPK14 Proteins)-MSK signaling pathway is essential for the regulation of the phenotype and of the CST5/cystatin D candidate tumor suppressor and other target genes by 1,25(OH)2D3 in colon cancer cells
Compared with its homologues, cystatin D presents an unusual inhibition profile with a preferential inhibition cathepsin S (show CTSS Proteins) > cathepsin H (show CTSH Proteins) > cathepsin L (show CTSL1 Proteins) and no inhibition of cathepsin B (show CTSB Proteins) or pig legumain (show LGMN Proteins).
Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells.
Cst10 may play an important role in the last steps of the chondrocyte differentiation pathway as an inducer of maturation, followed by apoptosis of chondrocytes
Data show that cystatin (show CST3 Proteins) 10 (carminerin) contributes to chondrocyte calcification during endochondral ossification under physiological and pathological conditions through the transcriptional inhibition of NPP1 (show ENPP1 Proteins).
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein found in saliva and tears. The encoded protein may play a protective role against proteinases present in the oral cavity.
, cystatin 5
, cysteine-proteinase inhibitor
, cystatin 10 (chondrocytes)