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Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 Proteins (CYP2B6)

CYP2B6, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP2B6 Antibodies (55) and CYP2B6 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CYP2B6 CYP2B6 286953 P13107
CYP2B6 1555 P20813
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Top CYP2B6 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

CYP2B6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

More Proteins for Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6) Interaction Partners

Human Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6) interaction partners

  1. Analysis of gene-gene interactions with CYP2B6 was particularly useful to reinforce the role of MRP4 and to reveal unknown associations, such as that of DRD3 (show DRD3 Proteins).

  2. POR (show POR Proteins) rs2868177 and CYP2B6*6 variants contribute to the interindividual variability in human CYP2B6 activity, which may affect the disposition and interaction of other CYP2B6 substrate drugs

  3. CYP2B6*6 and *9 variant alleles had a significant decreasing effect on sertraline metabolism in major depression patients.

  4. Combined 3D-QSAR and docking procedures yielded precise information about the common and distinct interactions of inhibitors and the enzyme active sites of CYP2B6.

  5. the cytochrome P450 oxidoreductase (show TXNRD1 Proteins) g.6593A>G polymorphism significantly influences CYP2B6 activity

  6. Observation in Chinese patients with systemic lupus erythematosus indicated that the combination genetic marker of CYP2C19 (show CYP2C19 Proteins)*2 and CYP2B6 -750 T > C genotypes was associated with 4-OH-CPA (show CPA1 Proteins) plasma concentration, short term efficacy and adverse reactions of cyclophosphamide.

  7. Data suggest that primary cytochrome P450 in liver microsomes catalyzing 9-hydroxylation of (-)-cis (show CISH Proteins)- and (-)-trans-rose oxide is CYP2B6 (and CYP2C19 (show CYP2C19 Proteins) to some extent); rose oxide is aroma compound from essential oils and is used in food and perfume.

  8. CYP2B6 516G>T SNP is prevalent in Aregntinian population.

  9. Both Cyp2b6 CT/TT genotype of rs8192719 (c.1294 + 3C > T) and AG genotype of rs2279343 (c.785A > G) prolonged survival (p < 0.05).

  10. Data suggest peripheral ligand-binding pocket and active site are located on opposite sides of the I-helix in CYP2B6; similar results were obtained for CYP2B4.

CYP2B6 Protein Profile

Protein Summary

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described\; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

Gene names and symbols associated with CYP2B6

  • cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B6)
  • cytochrome P450, family 2, subfamily B, polypeptide 6 (cyp2b6)
  • cytochrome P450 2B11 (CYP2B6)
  • cytochrome P450, family 2, subfamily b, polypeptide 3 (Cyp2b3)
  • CPB6 protein
  • CYP2B protein
  • Cyp2b6 protein
  • CYP2B7 protein
  • CYP2B7P protein
  • CYP2B11 protein
  • CYP2B30 protein
  • CYPIIB6 protein
  • CYPIIB11 protein
  • EFVM protein
  • IIB1 protein
  • P450 protein

Protein level used designations for CYP2B6

cytochrome P450 2B6 , cytochrome P450 CYP2B30 , cytochrome P450, family 2, subfamily B, polypeptide 6 , cytochrome P450 PBD-2 , cytochrome P450, family 2, subfamily B, polypeptide 11 , CYPIIB3 , cytochrome P450 2B3 , cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6 , cytochrome P450IIB3 , 1,4-cineole 2-exo-monooxygenase , cytochrome P450 IIB1

678687 Macaca mulatta
494798 Xenopus laevis
474177 Canis lupus familiaris
286953 Rattus norvegicus
1555 Homo sapiens
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