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anti-Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1) Antibodies

CYP27A1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP27A1 Kits (9) and CYP27A1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CYP27A1 1593 Q02318
CYP27A1 104086 Q9DBG1
CYP27A1 301517 P17178
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Top anti-CYP27A1 Antibodies at

Showing 10 out of 52 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CYP27A1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human brain 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Log in to see 14 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HeLa cells, using Cytochrome P450 27A1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: A549 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image CYP27A1 antibody detects CYP27A1 protein at cytoplasm in human endometrial carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human endometrial carcinoma. CYP27A1 antibody , diluted at 1:500. 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: CYP27A1 Antibody [NBP2-16063] - Immunohistochemical analysis of paraffin-embedded hela xenograft, using antibody at 1:500 dilution. Western Blot: CYP27A1 Antibody [NBP2-16063] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 6 to 9 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: CYP27A1 Antibody [NBP2-16062] - A. 50 ug rat liver lysate/extract. Western Blot: CYP27A1 Antibody [NBP2-16062] - Sample (50 ug of whole cell lysate) A: Mouse Liver. Diluted at 1:1000. 0.1 mL Log in to see 6 to 9 Days
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Cytochrome P450 27A1 staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Cytochrome P450 27A1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse liver tissue labeled with Anti-CYP27A1 Polyclonal Antibody, Unconjugated (ABIN708911) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days

CYP27A1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-CYP27A1 Antibodies

  1. Human Polyclonal CYP27A1 Primary Antibody for WB - ABIN2784620 : Szlago, Gallus, Schenone, Patiño, Sfaelo, Rufa, Da Pozzo, Cardaioli, Dotti, Federico: The first cerebrotendinous xanthomatosis family from Argentina: a new mutation in CYP27A1 gene. in Neurology 2008 (PubMed)

More Antibodies against CYP27A1 Interaction Partners

Human Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1) interaction partners

  1. A significant decrease in the expression level of CYP27A1 in female patients could indicate their greater vulnerability to multiple sclerosis than the male patients.

  2. CYP27A1 belongs to the mitochondrial CYPs and plays a crucial role in the cholesterol homeostasis.

  3. Analysis of ~60,000 human exomes points to underdiagnosis of cerebrotendinous xanthomatosis due to CYP27A1 mutations.

  4. marinobufagenin is derived from bile acids and its biosynthesis is initiated by CYP27A1 enzyme

  5. The 25-hydroxylases CYP2R1 (show CYP2R1 Antibodies) and CYP27A1 catalyze vitamin D to its circulating form 25-hydroxyvitamin D.

  6. In a patient with cerebrotendinous xanthomatosis, analysis of the CYP27A1 gene identified compound heterozygosity for p.A335V, a novel mutation.

  7. study describes two unrelated Sardinian families sharing the same CYP27A1 mutation, p.Arg479Cys; phenotype of the patients is characteristic of cerebrotendinous xanthomatosis

  8. The increased cutaneous CYP27B1 (show CYP27B1 Antibodies) levels in the CKD patients suggest that the loss of renal activity of this enzyme is at least partially compensated for by the skin.

  9. Cyp27A1 mutations were identified in early onset CAD (show CAD Antibodies) pedigree.

  10. Studied whether abnormal endometrial expression of CYP27A1 and/or CYP2R1 (show CYP2R1 Antibodies) may impair VDR (show CYP27B1 Antibodies)-antiproliferative properties in endometrial carcinoma.

Mouse (Murine) Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1) interaction partners

  1. The cholesterol diet reduced the levels of the "memory protein" Arc (Activity Regulated Cytoskeleton associated protein (show Arc Antibodies)) in the hippocampus of the wildtype mice but not in the hippocampus of the Cyp27-/- mice.

  2. overexpression of Cyp27a1 in KCs reduces hepatic inflammation independently of 27HC levels in plasma and liver, further pointing towards KCs as specific target for improving the therapy of NASH (show SAMSN1 Antibodies).

  3. Data indicate that inhibition of CYP27A1 activity or knockdown and deletion of the Cyp27a1 gene induced adipocyte differentiation.

  4. The expression of CYP27A1 modulates the concentrations of active glucocorticoids in both humans and mice and in vitro.

  5. Loss of CYP27A1 led to dysregulation of retinal cholesterol homeostasis, including unexpected upregulation of retinal cholesterol biosynthesis. Cyp27a1-/- mice developed retinal lesions with cholesterol deposition beneath the retinal pigment epithelium.

  6. CYP27(-/-) mice exhibited enhanced CCl(4 (show CCL4 Antibodies))-induce liver injury, and defective liver regeneration and prolonged steatosis after 70% partial hepatectomy.

  7. Results are consistent with a concentration-dependent flux of 7alpha-hydroxy-4-cholesten-3-one across the blood-brain barrier in cyp27a1(-/-) mice and subsequent formation of cholestanol.

  8. In CYP27A1 ko mice, urinary progesterone concentrations were decreased, 20alpha-DH-progesterone increased, and the progesterone-to-20alpha-DH-progesterone ratio decreased threefold

  9. Hepatic neutral cytosolic cholesteryl ester hydrolase decreased mRNAs for cholesterol 7alpha-hydroxylase (show CYP7A1 Antibodies), sterol 27-hydroxylase, and HMG-CoA reductase (show HMGCR Antibodies) on day 7 after transfection, coinciding with peak hepatic free cholesterol concentrations

Cow (Bovine) Cytochrome P450, Family 27, Subfamily A, Polypeptide 1 (CYP27A1) interaction partners

  1. isoLG adduction impairs enzyme activity, and support our hypothesis that isoLG modification in the retina is detrimental to CYP27A1 enzyme activity, potentially disrupting cholesterol homeostasis.

  2. Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 (show POR Antibodies) CYP27A1 and CYP11A1 (show CYP11A1 Antibodies).

  3. Sterol 27-hydroxylase cytochrome P450 27A1 (CYP27A1) is involved in elimination of 7-ketocholesterol from the retinal pigment epithelium.

CYP27A1 Antigen Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.

Gene names and symbols associated with CYP27A1

  • cytochrome P450, family 27, subfamily A, polypeptide 1 (CYP27A1) antibody
  • cytochrome P450, family 27, subfamily a, polypeptide 1 (Cyp27a1) antibody
  • sterol 26-hydroxylase, mitochondrial (CYP27A1) antibody
  • vitamin D3 25-Hydroxylase (CYP2D25) antibody
  • 1300013A03Rik antibody
  • CP27 antibody
  • CTX antibody
  • Cyp27 antibody
  • CYPIID25 antibody
  • P450C27 antibody

Protein level used designations for CYP27A1

5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase , 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase , 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase , cholestanetriol 26-monooxygenase , cytochrome P-450C27/25 , cytochrome P450 27 , cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1 , sterol 26-hydroxylase, mitochondrial , sterol 27-hydroxylase , vitamin D(3) 25-hydroxylase , cholesterol 27 hydroxylase , cytochrome P450, 27 , cytochrome P450, 27a1 , cytochrome P-450c27/25 , cytochrome P-450 , cytochrome P450 2D25

1593 Homo sapiens
104086 Mus musculus
610489 Canis lupus familiaris
100126282 Sus scrofa
511960 Bos taurus
301517 Rattus norvegicus
100348736 Oryctolagus cuniculus
397687 Sus scrofa
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